Tanmayee Samantaray

Hi Srinivas, Thanks for your kind reply. We did a 30 component SBM decomposition of Healthy controls (HC) and Parkinson's (PD) data. Almost all the maps had predominant positive regions. Next, we obtained the mean of the HC and PD loading coefficients for all 30 components. We observed 15 components showing PD > HC (meaning PD has more grey matter than HC), and the rest 15 components showing HC>PD (meaning HC has more grey matter than PD). This seems to imply half of the brain regions have higher...

Hi!! I decomposed structural MRI of healthy controls and patient group using GIFT toolbox and obtained loading matrix and component matrix. The mean of the loading coefficients of healthy control is coming negative, while that of patients is coming positive. Does this mean that the tissue content of healthy is more than that of patients? If so, how is it even practically possible? Please explain on the directionality of the loading coefficients. Looking forward to this.

Hi!! I decomposed structural MRI of healthy controls and patient group using GIFT toolbox and obtained loading matrix and component matrix. The mean of the loading coefficients of healthy control is coming negative, while that of patients is coming positive. Does this mean that the tissue content of healthy is more than that of patients? If so, how is it even practically possible? Please explain on the directionality of the loading coefficients. Looking forward to this.