Hi, The SOAP APIs that are used to get data from ChemSpider have been retired, there are new APIs that replace the SOAP APIs and are described at https://developer.rsc.org. There is a short example of using the new APIs in an R script here: https://www.linkedin.com/pulse/getting-started-chemspider-apis-using-knime-r-php-david-schiessel?articleId=6444233959156121600#comments-6444233959156121600&trk=prof-post If you have any questions or need any help please contact the support team at api-at-rsc.org....