Cytokine Production Terms

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Hi Alex - the indentation of the DAG hasn't come out - can you submit
it again and use dashes (-) instead of spaces please? cheers, Jane.

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Resubmitted with indentation clarified -- Alex

New Term: cytokine production (and associated regulation terms)

Definition: The synthesis and release of a cytokine following a
stimulus, resulting in an increase in its intracellular or
extracellular levels.

Comment: Note that this term is intended for use when a gene
product is seen to cause apparent increases in intracellular or
extracellular cytokine levels, without specific regard as to whether
the increase is due to increased biosynthesis, increased secretion
of preexisting cytokine molecules, or increased conversion from
precursor molecules.

Parentage (DAG View):
---immune response
------< cytokine production ; GO:New Term
---------< cytokine biosynthesis ; GO:0042089
---------< cytokine secretion ; GO:0050663
---------< regulation of cytokine production ; GO:New Term
------------% negative regulation of cytokine production ; GO:New
Term
---------------< negative regulation of cytokine biosynthesis ;
GO:0042036
---------------< negative regulation of cytokine secretion ;
GO:0050710
------------% positive regulation of cytokine production ; GO:New
Term
---------------< positive regulation of cytokine biosynthesis ;
GO:0042108
---------------< positive regulation of cytokine secretion ;
GO:0050715
------------< regulation of cytokine biosynthesis ; GO:0042035
------------< regulation of cytokine secretion ; GO:0050707

Reference: Fundamental Immunology (ISBN 0-727-3514-9)

Cytokine production for specific cytokines may be added as
children to this term as necessary. Such terms are useful in the
GO because they can be indicative of the course of an immune
response.

The regulation terms:
New Term: regulation of cytokine production

Definition: Any process that modulates the frequency, rate, or
extent of production of a cytokine.

Reference: Fundamental Immunology (ISBN 0-727-3514-9)

New Term: negative regulation of cytokine production

Definition: Any process that stops, prevents, or reduces the rate
of production of a cytokine.

Reference: Fundamental Immunology (ISBN 0-727-3514-9)

New Term: positive regulation of cytokine production

Definition: Any process that activates or increases the rate of
production of a cytokine.

Reference: Fundamental Immunology (ISBN 0-727-3514-9)

The cytokine biosynthesis and cytokine secretion terms and their
associated regulation terms should all retain their original
locations in the process DAG in addition to their new relationships
indicated above.

-- Alex

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I've given this to Harold to enter next week. I will update the
entry when it has been entered.

-- Alex