links between checkpoints and -ve reg of transitions

I meant to delete these two lines before I submiteted this ticket.

cytokinesis*** checkpoint (GO:0000078) (G2 arrest)/cell shape –ve reg. G2/M
cytokinesis after mitosis checkpoint (GO:0031565) septin checkpoint /chr.seg. completion defects

For these please refer to
https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3610914&group_id=36855

I have contacted SGD for feedback on the mitotic spindle orientation checkpoint

mitotic spindle orientation checkpoint

Hi,

Replied directly via email but adding to the item as well. You are correct that in budding yeast the Spindle Position or Orientation Checkpoint delays mitotic exit preventing the completion of anaphase. See PMID:10934478 (BUB2), 16039591 (KIN4) and reviewed in PMID:21143992.

Cheers,
Rob

Thank Rob,
The review here says that
SPOC delays the exit from mitosis by inhibiting the mitotic exit network (MEN) in response to spindle orientation defects

GO:0001100 negative regulation of exit from mitosis

(but I think this could also be negative regulation of anaphase /telophase transition? perhaps a synonym

I didn't finish this comment
so
mitotic spindle orientation checkpoint -> regulation of mitotic exit (aka negative regulation of anaphase/telophase transition)

Hi Val - these are all now in, but for the mitotic spindle orientation checkpoint, its parent, 'spindle checkpoint' has the following definition:

A cell cycle checkpoint that delays progression through the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.

But you're saying that in Cerevisiae, the mitotic spindle orientation checkpoint doesn't regulate the metaphase/anaphase transition, it instead regulates the anaphase /telophase transition?

So the def of the "spindle checkpoint" probably needs broadening to refer to
the metaphase anaphase transition (for assembly) AND the *** transition for orientation

As for the orientation, Rob says above that it is mitotic exit which is regulated
so it should be

GO:0001100 negative regulation of exit from mitosis by spindle orientation checkpoint signalling

(I still think this would synonymous with the term we obsoleted M/G1 transition, which our experts said didn't exist)

• Description has changed:

Diff:

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+++ new
@@ -1,4 +1,3 @@
-

 G1 DNA damage checkpoint: -ve regulation of G1/S transition
 G1 DNA damage checkpoint: -ve regulation of G2/M transition
@@ -9,8 +8,6 @@
 mitotic spindle assembly checkpoint \(aka SAC/mitotic checkpoint\);  –ve reg. metaphase/anaphase transition \(via APC\)
 mitotic spindle orientation checkpoint  \(my notes say delays anaphase completion?\), I think this is only in S. cerevisiae so we need to check with SGD which transition is being regulated, if any \(I will do this\)

-cytokinesis\*\*\*  checkpoint \(GO:0000078\) \(G2 arrest\)/cell shape –ve reg. G2/M
-cytokinesis after mitosis checkpoint \(GO:0031565\) septin checkpoint /chr.seg. completion defects 

 other cytokinesis checkpoint, changes still need implementing, I'll put these in another ticket

• Group: --> None

• Description has changed:

Diff:

--- old
+++ new
@@ -1,6 +1,5 @@
-
 G1 DNA damage checkpoint: -ve regulation of G1/S transition
-G1 DNA damage checkpoint: -ve regulation of G2/M transition
+G2 DNA damage checkpoint: -ve regulation of G2/M transition
 S-M DNA replication checkpoint : -ve regulation of G2/M transition
 intra-S DNA damage checkpoint  ? \(not sure about this one, it might just slow replication, rather than the transition, will check, Val\)
 G1 cell size control checkpoint: -ve regulation of G1/S transition

all of the cell cycle checkpoint signal transduction terms now have "negative regulation of transition" parents for the respective transitions, except for
intra-S DNA damage checkpoint , we have no notes on what this negatively regulates (possibly slows replication rahter than a transition)?

I will open a new ticket for this

Also the mitotic spindle def problems noted by Jane, will be fixed by
https://sourceforge.net/p/geneontology/ontology-requests/10322/