Compare the Top Systems Engineering & MBSE Software that integrates with Python as of July 2025

This a list of Systems Engineering & MBSE software that integrates with Python. Use the filters on the left to add additional filters for products that have integrations with Python. View the products that work with Python in the table below.

What is Systems Engineering & MBSE Software for Python?

Systems engineering and MBSE software enables engineers and systems designers to create and simulate system designs using a GUI. Systems engineering software streamlines and simplifies the process of designing a system such as factory machines, industrial equipment systems, IoT systems, and more. Model-based systems engineering (MBSE) software enables systems designers to model systems based on specific requirements. Compare and read user reviews of the best Systems Engineering & MBSE software for Python currently available using the table below. This list is updated regularly.

  • 1
    Simcenter Amesim
    Simcenter Amesim is a leading integrated, scalable mechatronic system simulation platform that allows design engineers to virtually assess and optimize the systems’ performance. This will boost overall systems engineering productivity from the early development stages until the final performance validation and controls calibration. It allows its users to focus on engineering, deliver accurate and actionable results, develop scalable models supporting the entire development cycle, improve collaboration and integrate system performance with other engineering disciplines. Simcenter Amesim is part of the Siemens Xcelerator portfolio, the comprehensive and integrated portfolio of software and services from Siemens Digital Industries Software.
  • Previous
  • You're on page 1
  • Next