Best Secure Email Gateway Software for Microsoft 365
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Compare the Top Secure Email Gateway Software that integrates with Microsoft 365 as of November 2025
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This a list of Secure Email Gateway software that integrates with Microsoft 365. Use the filters on the left to add additional filters for products that have integrations with Microsoft 365. View the products that work with Microsoft 365 in the table below.
What is Secure Email Gateway Software for Microsoft 365?
Secure email gateways protect organizations from email-based threats such as phishing, malware, spam, and data breaches. They analyze incoming and outgoing messages to detect suspicious content, malicious attachments, and unauthorized data sharing. These gateways enforce email security policies, filter harmful traffic, and provide encryption to safeguard sensitive communications. Many platforms also integrate with cloud email services like Microsoft 365 and Google Workspace to extend protection across hybrid environments. Ultimately, secure email gateways help maintain compliance, protect confidential information, and ensure safe, reliable business communication. Compare and read user reviews of the best Secure Email Gateway software for Microsoft 365 currently available using the table below. This list is updated regularly.
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1
NeoCertified Secure Email
NeoCertified
NeoCertified protects sensitive information through our secure email application across our versatile Cloud-based platform on any web browser, through Microsoft Office 365/Outlook plug-ins, and Gmail integration. iPhone + Android mobile apps are also available directly on your mobile devices. We have provided federally compliant, secure email solutions since 2002, and have helped businesses send and receive secure emails on any web browser or mobile device. NeoCertified also works across all email providers to give businesses the flexibility and assured protection they desire and deserve.Starting Price: $99.00/year/user -
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N-able Mail Assure
N-able
N-able Mail Assure cloud-based email security solution provides advanced threat protection for inbound and outbound email using collective threat intelligence, 24/7 email continuity, and long-term email archiving. The service includes a multitenant web-interface with predefined settings, reporting, and views designed to ensure control and visibility over email flows. N-able Mail Assure’s proprietary technology incorporates input from processing large volumes of email data that feeds the Intelligent Protection and Filtering Engine. This combined with real-time pattern threat recognition leveraging a variety of filtering technologies help protect against spam, viruses, phishing attacks, impersonation, spoofing, malware, and other email-borne threats. -
3
Microsoft Exchange
Microsoft
Work smarter with business-class email and calendaring. Exchange helps you collaborate on your critical documents and gives you a focused inbox that prioritizes important messages and adapts to your work style, so you can get more done–faster. Get access to a more personalized inbox with helpful features and a smarter, more organized way to view and interact with email. Search enhancements give you faster and more complete results. With Add-ins, get powerful customization and extensibility, which connect you to modern services and internal line-of-business applications. Organize your time with a calendaring system that goes beyond basic scheduling of appointments and commitments. Automatically capture events from email such as flights and hotel reservations, and get suggestions about where to meet based on your location. Microsoft Exchange Online offers a hosted email service for business. Exchange Online helps protect your information with advanced capabilities. -
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Advanced protection to safeguard your inboxes. Email is still the No. 1 threat vector. Expand the scope of your defenses to detect dangerous threats and rapidly respond to and remediate new threats in real time. Identify the malicious techniques used in attacks targeting your organization. Understand the specific business risks and categorize threats to gain insight into the parts of your organization that are most vulnerable to attack. AI-driven threat detection uses multiple detection engines to simultaneously evaluate different portions of an incoming email. These verdict details help ensure accurate threat classification, identify business risk, and promote an appropriate response action. Threats come from numerous sources: phishing, business email compromise, malware, and ransomware. Defend against all of them with industry-leading threat intelligence that empowers you to act quickly.
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SecurityGateway™ for Email Servers
MDaemon Technologies
Developed by MDaemon Technologies, an email industry pioneer, Security Gateway's email threat detection technology has been protecting email servers from viruses, spam, phishing, data loss and other threats for over 20 years. Simply put, companies trust our expertise to help keep email communications safe. We protect all email platforms including Microsoft Exchange, Office 365 and others. Let our team of email security experts take the headache out of managing your company's email security needs. Security Gateway uses the latest email threat detection technology and policy enforcement tools to keep good emails flowing to and from your users. The Security Gateway cloud service can be deployed quickly and easily, allowing you to focus on other important tasks. Watch a short video to learn about some of the Security Gateway features.Starting Price: $1 per user per month -
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Symantec Email Security.cloud
Broadcom
Safeguard Microsoft Office 365, Google G Suite, and on-premises email with the industry’s most complete email security solution. Insulate users from spear phishing, credential theft and ransomware attacks by using Email Threat Isolation. Prevent insidious email threats such as spear phishing, ransomware, business email compromise and email spam. Stop spear phishing emails with multiple layers of protection, threat isolation, spam filtering, advanced security email analytics, built-in user awareness, education tools, and more. Block the latest ransomware with content defense, sandboxing, and link protection technologies that detect emerging, stealthy, and zero-day attacks. Defeat business email compromise with impersonation protection, sender authentication enforcement and brand protection controls. Protect your brand reputation by using automation to solve the practical issues of enforcing sender authentication (DMARC, DKIM and SPF) with Symantec Email Fraud Protection. -
7
Spambrella
Spambrella
Dynamically classify imposter email. Preemptively identify and sandbox suspicious URLs. Leverage big-data analysis to accurately classify bulk mail. All within a single service that connects with Microsoft 365 and Google Workspace. Spambrella’s Email Security and User Awareness Training technology is used by some of the World’s largest and most successful security-conscious companies in a multitude of continents and environments. Delivered on a global scale, Spambrella is ready to unify your email security and user awareness training requirements. Think of us as your outsourced email security team! We have deep technical expertise of all other service providers such as MxLogic, Mimecast, Symantec.cloud and know how to migrate you effortlessly. Schedule a demo today with our cybersecurity experts to uncover email threats targeting your email users.Starting Price: $1.00 -
8
LuxSci
Lux Scientiae
LuxSci provides HIPAA-compliant web and email communications services. LuxSci creates uniquely secure and customizable enterprise-grade environments and solutions that enable organizations to confidently meet their specific business and security needs at scale. LuxSci’s HIPAA-compliant email and web solutions are HITRUST certified and include: • Secure High Volume Sending for delivering massive volumes of transactional and marketing emails. • Secure SMTP Connector for encrypting outbound emails sent from Microsoft 365 and Google Workspace. • Secure Email Marketing platform for creating and sending marketing campaigns with ePHI. • Secure Email Hosting for reliable and secure day-to-day business email. • Fully managed Secure Web and Database Hosting for web applications that require compliance. • Secure Forms to safely collect and store sensitive information. LuxSci provides a full suite of secure technology for companies requiring compliant web and email services.Starting Price: $4 per/user/month -
9
PhishProtection
DuoCircle
Make your smartest investment to reduce email security threats today, and get a comprehensive email security protection solution with small business pricing. Cybercriminals are targeting CEOs, CFOs, HR, Accounting Departments and regular employees across every industry. As you know Office 365 is extremely limited in the protection that you can configure to stop impersonations, email fraud and phishing. There are only so many custom transport rules you can build to constantly block domains or protect against employee impersonations. PhishProtection works on every email server, device or smtp service. No matter if you are on your phone, or outlook or any email client anywhere, we can protect you. It offers best-in-class security to iOS and Android devices alike.Starting Price: $100/month/user -
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Additional layer of security to stop threats from ever reaching users in the network. Designed to protect email communication, the most vulnerable vector. ESET features a true 64-bit product that allows for clustering to ensure that speed is never a concern for organizations of any size. ESET Mail Security solutions use in-house developed anti-spam, anti-phishing and host server protection, combining machine learning, big data and human expertise into one award-winning mail security platform. Helps eliminate unsolicited emails and targeted attacks, allowing employees to focus on their job and ensure business continuity. Users are constantly targeted via phishing campaigns that may contain other malicious components. A single user will not be efficient due to having to sift through whether emails are legitimate or not. Emails are automatically provided to users about their spam emails that were quarantined.Starting Price: $132 per 5 devices per year
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11
RevBits Email Security
RevBits
RevBits Email Security is a next-generation email security solution that aims to close major gaps in the current marketplace. Leveraging sophisticated and unique algorithms such as a patented page impersonation detection methodology, Revbits Email Security achieves the deepest level of email analysis. For every email, RevBits Email Security displays a composite, probabilistic score of each email's risk level paired with full details for continuing user education. RevBits Email Security enhances Email Security Architecture RevBits Email Security enhances email security by detecting and blocking sophisticated malicious emails that get past the outer layers of an organization's email security stack. With RevBits Email Security, organizations can protect the last point of email interaction – the employee endpoint. -
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Trustwave Secure Email Gateway
Trustwave
Delivers advanced protection against today’s sophisticated email-based threats, extensive policy controls, and in-depth data security and compliance management. Protecting your email environment against spam, malware, phishing attacks, business email compromise, account takeover, ransomware and more is one of your top priorities. Trustwave Secure Email Gateway (SEG) multi-layered intelligence and detection engine performs deep analysis of your inbound email traffic, in real-time, to protect your users from cyber threats, enables you to integrate the workflow of your email content into business processes, while scrutinizing outbound email traffic to prevent the loss of your proprietary data, intellectual property, confidential documents and financial records. These security modules, used in conjunction with Secure Email Gateway, provide additional layers of protection and compliance capabilities for your business.
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