Best Network Detection and Response (NDR) Software for Microsoft 365

Compare the Top Network Detection and Response (NDR) Software that integrates with Microsoft 365 as of October 2025

This a list of Network Detection and Response (NDR) software that integrates with Microsoft 365. Use the filters on the left to add additional filters for products that have integrations with Microsoft 365. View the products that work with Microsoft 365 in the table below.

What is Network Detection and Response (NDR) Software for Microsoft 365?

Network detection and response (NDR) software and solutions enable organizations to monitor network activity to identify potential security threats, and alert teams of these potential threats when they arise. Compare and read user reviews of the best Network Detection and Response (NDR) software for Microsoft 365 currently available using the table below. This list is updated regularly.

  • 1
    Trellix Network Detection and Response (NDR)
    Detect the undetectable and stop evasive attacks. Trellix Network Detection and Response (NDR) helps your team focus on real attacks, contain intrusions with speed and intelligence, and eliminate your cybersecurity weak points. Keep your cloud, IoT, collaboration tools, endpoints, and infrastructure safe. Automate your responses to adapt to the changing security landscape. Integrate with any vendor—and improve efficiency by surfacing only the alerts that matter to you. Minimize the risk of costly breaches by detecting and preventing advanced, targeted, and other evasive attacks in real time. Discover how you can take advantage of actionable insights, comprehensive protection, and extensible architecture.
  • 2
    Darktrace

    Darktrace

    Darktrace

    Darktrace is a cybersecurity platform powered by AI, providing a proactive approach to cyber resilience. Its ActiveAI Security Platform delivers real-time threat detection, autonomous responses to both known and novel threats, and comprehensive visibility into an organization’s security posture. By ingesting enterprise data from native and third-party sources, Darktrace correlates security incidents across business operations and detects previously unseen threats. This complete visibility and automation reduce containment time, eliminate alert fatigue, and significantly enhance the efficiency of security operations.
  • 3
    Vectra AI
    Vectra enables enterprises to immediately detect and respond to cyberattacks across cloud, data center, IT and IoT networks. As the leader in network detection and response (NDR), Vectra uses AI to empower the enterprise SOC to automate threat discovery, prioritization, hunting and response. Vectra is Security that thinks. We have developed an AI-driven cybersecurity platform that detects attacker behaviors to protect your hosts and users from being compromised, regardless of location. Unlike other solutions, Vectra Cognito provides high fidelity alerts instead of more noise, and does not decrypt your data so you can be secure and maintain privacy. Today’s cyberattacks will use any means of entry, so we provide a single platform to cover cloud, data center, enterprise networks, and IoT devices, not just critical assets. The Vectra NDR platform is the ultimate AI-powered cyberattack detection and threat-hunting platform.
  • 4
    Sensato Nightingale

    Sensato Nightingale

    Sensato Cybersecurity Solutions

    Nightingale Compliance Manager (CM) provides organizations with a rapid means of determining maturity as well as managing risk and policy exceptions. Nightingale Detection Manager combines network and host intrusion detection, honeypots, and vulnerability assessments to provide unparalleled protection. Nightingale Response Manager (RM) modernizes incident response by integrating playbooks, rapid response and automated countermeasures. We believe genuinely effective cybersecurity is based on a holistic cybersecurity strategy. To enable this, a single platform is essential—a fully integrated platform out-of-the-box. That platform must incorporate your ability to comply with best practices, detect all attacks, and respond quickly. That platform is Nightingale. Practical approaches and solutions to help you achieve and maintain compliance. Industry-leading tools and practices, based on the real-world critical response, help you not just respond but also contain, fight back and recover.
  • 5
    Proofpoint Identity Threat Defense
    In an ever-changing hybrid world, your organization depends on its employees, their virtual identities, and the endpoints they operate on to build and protect its assets. Threat actors have found unique ways to move laterally across your cloud environments by exploiting such identities. You need an innovative and agentless identity threat detection and response solution to discover and remediate modern identity vulnerabilities—a key part of today’s attack chain. Proofpoint Identity Threat Defense, previously Illusive, gives you comprehensive prevention and visibility across all your identities so you can remediate identity vulnerabilities before they become real risks. You can also detect any lateral movements in your environments and activate deception to ensure threat actors are stopped in action before they gain access to your corporate assets. It doesn’t get better than knowing you can prevent modern identity risks and stop real-time identity threats in action, all in one place.
  • 6
    Securonix Unified Defense SIEM
    Built on big data, Securonix Unified Defense SIEM combines log management, user and entity behavior analytics (UEBA), and security incident response into a complete, end-to-end security operations platform. It collects massive volumes of data in real-time, uses patented machine learning algorithms to detect advanced threats, and provides artificial intelligence-based security incident response capabilities for fast remediation. The Securonix platform automates security operations while our analytics capabilities reduces noise, fine tunes alerts, and identifies threats both inside and out of the enterprise. The Securonix platform delivers analytics driven SIEM, SOAR, and NTA, with UEBA at its core, as a pure cloud solution without compromise. Collect, detect, and respond to threats using a single, scalable platform based on machine learning and behavioral analytics. With a focus on outputs, Securonix manages the SIEM so you can focus on responding to threats.
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