Best Managed Detection and Response (MDR) Services for Microsoft 365

Compare the Top Managed Detection and Response (MDR) Services that integrate with Microsoft 365 as of October 2025

This a list of Managed Detection and Response (MDR) services that integrate with Microsoft 365. Use the filters on the left to add additional filters for products that have integrations with Microsoft 365. View the products that work with Microsoft 365 in the table below.

What are Managed Detection and Response (MDR) Services for Microsoft 365?

Managed detection and response (MDR) software enables the monitoring of endpoint and network security in order to detect and solve potential threats. Compare and read user reviews of the best Managed Detection and Response (MDR) services for Microsoft 365 currently available using the table below. This list is updated regularly.

  • 1
    Blumira

    Blumira

    Blumira

    Achieve Enterprise-Level Security With Blumira Over An MDR An all-in-one solution with SIEM, endpoint visibility, 24/7 monitoring, and automated response to reduce complexity, increase visibility and speed up time to respond. Like a Managed Detection and Response solution, we handle the security heavy lifting, so you get time back in your day. With out-of-the-box detections, pre-filtered alerts, and response playbooks, IT teams can achieve real security value with Blumira. Quick Deployment, Immediate Results: Integrates with your tech stack and fully deploy, with no warm-up period, in hours All-You-Can-Eat Data Ingest: Predictable pricing and with unlimited data logging for full-lifecycle detection Compliance Made Easy: 1 year data retention included, pre-built reports, and 24/7 automated monitoring (MDRs drop a percent of logs after 30 days) Better Support Than an MDR: Product Solution Architects, Incident Detection Tea, and 24/7 SecOps with 99.7% CSAT scores.
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    Starting Price: Free Trial
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  • 2
    Guardz

    Guardz

    Guardz

    Guardz is the unified cybersecurity platform purpose-built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. Our identity-centric approach connects the dots across vectors, reducing the gaps that siloed tools leave behind so MSPs can see, understand, and act on user risk in real time. Backed by an elite research and threat hunting team, Guardz strengthens detection across environments, turning signals into actionable insights. With 24/7 AI + human-led MDR, Guardz utilizes agentic AI to triage at machine speed while expert analysts validate, mitigate, and guide response, giving MSPs scalable protection without adding headcount. Our mission is simple: give MSPs the scale, confidence, and clarity they need to stay ahead of attackers and deliver protection to every SMB they serve.
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  • 3
    Syncro

    Syncro

    Syncro

    Syncro offers the first Extended Monitoring and Management (XMM) platform purpose-built for midsized MSPs and internal IT teams. The unified platform integrates RMM (endpoint management), professional services automation (PSA), and Microsoft 365 multi-tenant management to help organizations simplify operations, strengthen security, and scale profitably. Syncro delivers powerful automation, native AI capabilities, deep Microsoft 365 integration, and seamless support for 50+ third-party tools—enabling teams to reduce complexity, cut costs, and uncover new revenue opportunities. Its transparent per-user pricing model and commitment to continuous innovation make it an ideal solution for modern IT operations. Learn more at syncromsp.com or follow Syncro on LinkedIn.
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    Starting Price: $129 per user per month
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  • 4
    ConnectWise Cybersecurity Management
    Define and Deliver Comprehensive Cybersecurity Services. Security threats continue to grow, and your clients are most likely at risk. Small- to medium-sized businesses (SMBs) are targeted by 64% of all cyberattacks, and 62% of them admit lacking in-house expertise to deal with security issues. Now technology solution providers (TSPs) are a prime target. Enter ConnectWise Cybersecurity Management (formerly ConnectWise Fortify) — the advanced cybersecurity solution you need to deliver the managed detection and response protection your clients require. Whether you’re talking to prospects or clients, we provide you with the right insights and data to support your cybersecurity conversation. From client-facing reports to technical guidance, we reduce the noise by guiding you through what’s really needed to demonstrate the value of enhanced strategy.
  • 5
    Defense.com

    Defense.com

    Defense.com

    Take control of cyber threats. Identify, prioritize and track all your security threats with Defense.com. Simplify your cyber threat management. Detection, protection, remediation, and compliance, are all in one place. Make intelligent decisions about your security with automatically prioritized and tracked threats. Improve your security by following the effective remediation steps provided for each threat. Gain knowledge and advice from experienced cyber and compliance consultants when you need assistance. Take control of your cyber security with easy-to-use tools that can work with your existing security investment. Live data from penetration tests, VA scans, threat intelligence and more all feeds into a central dashboard, showing you exactly where your risks are and their severity. Remediation advice is included for each threat, making it easy to make effective security improvements. Powerful threat intelligence feeds are mapped to your unique attack surface.
    Starting Price: $30 per node per month
  • 6
    RocketCyber
    RocketCyber delivers around-the-clock Managed SOC (Security operations Center) services that allow you to instantly enhance threat detection and response initiatives for your managed IT environments. Improve your security posture and alleviate threat concerns with expert-powered services. RocketCyber provides a 24/7/365 MDR service that enables robust threat detection and response across the IT environments you manage. Stop advanced threats, remove stress and enhance your security posture with expert-backed cybersecurity.
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    Expel

    Expel

    Expel

    We create space for you to do what you love about security (even if it's not thinking about it). Managed security: 24x7 detection, response, and resilience. We spot attacks and provide immediate answers. Recommendations are specific and data-driven. Transparent cybersecurity, no more MSSPs. No “internal analyst console.” No curtain to look (or hide) behind. No more wondering. Full visibility, see and use the same interface our analysts use. Get a real-time look at how we're making critical decisions. Watch investigations unfold. When we spot an attack, we’ll give you answers, written in plain English, that tell you exactly what to do. See exactly what our analysts are doing, even as an investigation is unfolding. You choose your own security tech. We make it work harder. Resilience recommendations measurably improve your security. Our analysts provide specific recommendations based on data from your environment and past trends.
  • 8
    Kroll Cyber Risk
    We are the world incident response leader. Merging complete response capabilities with frontline threat intelligence from over 3000 incidents handled per year and end-to-end expertise we protect, detect and respond against cyberattacks. For immediate assistance, contact us today. Tackle every facet of today and tomorrow’s threat landscape with guidance from Kroll’s Cyber Risk experts. Enriched by frontline threat intel from 3000+ incidents cases every year, our end-to-end cyber risk solutions help organizations uncover exposures, validate the effectiveness of their defenses, implement new or updated controls, fine-tune detections and confidently respond to any threat. Get access to a wide portfolio of preparedness, resilience, detection and response services with a Kroll Cyber Risk retainer. Get in touch for more info.
  • 9
    SilverSky Managed Security Services
    With the acceleration of cyber threats across new security vectors, the effort, skill, and technology needed to defend against these dangers continues to dramatically increase and become more complex. Security teams can quickly become overwhelmed. For over 20 years, SilverSky has evolved as a managed security service provider to serve the security and regulatory needs of our small and mid-sized clients with simple and cost-effective solutions. We specialize in serving highly regulated sectors. Monitoring the perimeter with firewalls is no longer good enough. Companies need to monitor all points of contact within their estate. This means networks, servers, databases, people and endpoints. The most efficient way to achieve this is with a professionally staffed Security Operations Center or SOC as a service. SilverSky Security Monitoring will monitor perimeter and core security devices to provide sufficient protection to exceed regulatory compliance.
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    Ingalls MDR

    Ingalls MDR

    Ingalls Information Security

    Our Managed Detection and Response (MDR) service is designed for advanced detection, threat hunting, anomaly detection and response guidance utilizing a defense-in-depth approach which monitors and correlates network activity with endpoints, logs and everything in between. Unlike a traditional Managed Security Service Provider (MSSP), our service is geared toward proactive prevention. We do this by utilizing the very latest in cloud, big data analytics technology, and machine learning along with the cybersecurity industry’s leading incident response team, to identify threats to your environment. We leverage the best of the commercial, open source, and internally-developed tools and methods to provide the highest fidelity of monitoring possible. We have partnered with Cylance to provide the best endpoint threat detection and prevention capability available on the market today, CylancePROTECT(™).
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    Symantec Integrated Cyber Defense
    The Symantec Integrated Cyber Defense (ICD) Platform delivers Endpoint Security, Identity Security, Information Security, and Network Security across on-premises and cloud infrastructures to provide the most complete and effective asset protection in the industry. Symantec is the first and only company to unify and coordinate security. Functions across both cloud and on-premises systems. Symantec enables enterprises to embrace the cloud as it makes sense for them, without sacrificing past investments and reliance on critical infrastructure. We know Symantec will never be your only vendor. That’s why we created Integrated Cyber Defense Exchange (ICDx), which makes it easy to integrate third-party products and share intelligence across the platform. Symantec is the only major cyber defense vendor that builds solutions to support all infrastructures, whether entirely on-premises, entirely in the cloud, or a hybrid of the two.
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    activeDEFENCE

    activeDEFENCE

    activereach

    From malware to advanced persistent threats (APT) to extortion & internal breaches, threats to your organisation’s infrastructure are unrelenting. Today’s businesses must consider smartphones, tablets, and consumerization of IT, combined with telecommuters, contractors, partners, and business-critical services hosted in the cloud. Security is more important than ever—and far more complex. To defend your information and systems, you need an adaptable, multi-layered defensive strategy that encompasses all the components of your IT environment, from the network to the perimeter, data, applications and endpoints, minimising and managing the weak points and vulnerabilities that expose your organisation to risk. activereach’s end-to-end portfolio of network security solutions can protect your business from advancing threats, enhance network performance, and optimise operational efficiencies.
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    Optiv Managed XDR
    Attackers are stealthy, relentless and motivated, and might use the same tools you do. They hide in your environment and quickly expand access. We understand the cyber ecosystem because it’s where we live, it’s where we operate. Our MXDR solution’s secret sauce derives from that pedigree, tested processes, proven IP, best-of-breed technology, leveraged automation and providing top-shelf talent to manage it all. Let’s collaborate and develop a custom solution with comprehensive threat visibility, accelerated incident identification, investigation, triage and mitigation actions to protect your enterprise from attacks and threats. We’ll start with your existing investments in endpoint, network, cloud, email and OT/IoT tools. Our experts will get those on the same team, actual technology orchestration! Reduces the attack surface, detects threats faster and automates deep investigation through a continuous approach.
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    Open Systems MDR+

    Open Systems MDR+

    Open Systems

    We improved our MDR so you aren’t flooded with alerts, and your business can keep moving. We’ve built it for modern business operations via a cloud-based SIEM, Microsoft Sentinel. Our SOC analysts are equipped with advanced AI detection and insights to identify threats earlier, determine which ones are real, and prioritize those with the highest potential for damage. We care deeply about our customers’ experience, so we have devised a way to minimize disruption by containing threats quickly and precisely. We call it MDR+. Our MDR+ solution combines human expertise, advanced threat detection processes, and world-class technology enabling you to react earlier in the kill chain. Azure Sentinel, with its vast ecosystems, already provides broad data ingestion and detection capabilities. Our use cases are enriched with powerful security playbooks that either run automatically or help the security analyst in taking the next steps.
  • 15
    Cybraics

    Cybraics

    Cybraics

    Stop chasing alerts and prevent incidents before they happen with the world's leading XDR platform that revolutionizes threat detection, log management, and response. Close the gaps and free your team with our silo-breaking, enterprise-class industry-leading XDR platform that covers compliance and simplifies security operations. Cybraics nLighten™ isn't just another security tool. Born out of AI and machine learning research with the U.S. Department of Defense, it's the catalyst to unlock actionable intelligence from the scattered and siloed data, logs, and alerts across multiple security tools in your network. And with Cybraics, powerful threat detection doesn't need to come at a premium. Powered by Adaptive Analytic Detection (AAD) and Persistent Behavior Tracing (PBT). Maximize security team efficacy with 96% automated actionable case creation and a 95% reduction in false positives. Reduce detection and response time from months to minutes.
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    AirMDR

    AirMDR

    AirMDR

    AI-powered virtual analysts automate 80-90% of routine tasks, delivering faster, higher-quality, and more affordable alert triage, investigation, and response, all supported by human experts. Say no to expensive, slow, poor quality, and inconsistent investigations. Say hello to precision investigations at blazing-fast speed. Traditional MDRs rely on human analysts for case triage, but at AirMDR, our intelligent virtual analyst processes these cases 20 times faster with greater consistency and depth. At AirMDR, human analysts have to manually triage over 90% fewer cases. Experience high-quality investigation, triage, and response for every alert, with 90% of alerts investigated in under five minutes. Every alert is automatically enriched, investigated, and triaged by our virtual analyst, serving as the first responder. This process is continuously supervised and enhanced by our team of human security experts, ensuring a seamless and efficient security operation.
  • 17
    Rotate

    Rotate

    Rotate

    Use the Rotate cloud security platform to secure any business with modular hubs and seamless integrations designed to scale your security needs. Gain greater context on cyberattacks and improve remediation by identifying alerts across all hubs, correlating them, and prioritizing incidents by risk level. Synthesize, consolidate, and manage all hubs in Rotate’s XDR. Use your multi-tenancy control center for vulnerability scans and rapid deployments. Manage unlimited clients through a single pane of glass. Empower your business customers with a complete cybersecurity solution and reduce portfolio risk. Rotate protects all types of organizations in the new world of digital-first work. Get complete cybersecurity for every employee who uses email or brings a device to work. Cyber insurance is essential for any organization at risk of a cyber attack, but coverage can be expensive. Comprehensive protection like the type provided by Rotate can help reduce the overall cost of insurance.
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    ConnectProtect Managed Detection and Response
    Choosing to outsource SIEM and SOC services to ConnectProtect® MDR enables your organisation to take advantage of SIEM and an experienced SOC to quickly provide your organisation with the knowledge and skills to reduce risk and effectively combat cyber threats. Through a combination of state-of-the-art technology and genuine human insight, you can get skilled security expertise at the turn of a key. Our simple and rapid onboarding process enables you to start realising value with minimal impact on your internal IT/Security teams. 24x7x365 monitoring of your secure access layers to help address the gap between automation and user awareness and alert you when something does slip through. We'll give you the management information (MI) to give you the confidence that things are working and improving. Let us help you embrace the benefits of ConnectProtect® Managed Detection and Response.
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    Proficio

    Proficio

    Proficio

    Proficio’s Managed, Detection and Response (MDR) solution surpasses the capabilities of traditional Managed Security Services Providers (MSSPs). Our MDR service is powered by next-generation cybersecurity technology and our security experts partner with you to become an extension of your team, continuously monitoring and investigating threats from our global networks of security operations centers. Proficio’s advanced approach to threat detection leverages an extensive library of security use cases, MITRE ATT&CK® framework, AI-based threat hunting models, business context modeling, and a threat intelligence platform. Through our global network of Security Operations Centers (SOCs), Proficio experts monitor, investigate and triage suspicious events. We significantly reduce the number of false positives and provide actionable alerts with remediation recommendations. Proficio is a leader in Security Orchestration Automation and Response (SOAR).
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