Compare the Top Layer 1 Protocols that integrate with Python as of September 2025

This a list of Layer 1 Protocols that integrate with Python. Use the filters on the left to add additional filters for products that have integrations with Python. View the products that work with Python in the table below.

What are Layer 1 Protocols for Python?

Layer 1 protocols, also known as layer 1 blockchains, are blockchain protocols that are built as the base layer of a blockchain. A layer 1 protocol serves as the underlying base blockchain of a blockchain network, as opposed to a layer 2 protocol which is designed to improve the scaling problems and transaction speeds and fees that layer 1 blockchain networks and protocols face. Decentralized applications and cryptocurrencies can be built on Layer 1 protocols, and layer 1 protocols interact with layer 2 protocols in order to improve efficiency and overall user experience. Compare and read user reviews of the best Layer 1 Protocols for Python currently available using the table below. This list is updated regularly.

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    Google Cloud Universal Ledger
    Google Cloud Universal Ledger (GCUL) is a next-generation, permissioned layer-1 blockchain platform designed for financial institutions to manage commercial bank money and tokenized assets with unprecedented simplicity, flexibility, and security. It offers a programmable, multi-currency distributed ledger accessible via a unified API, eliminates the complexity of traditional payment infrastructure, and supports atomic settlement for near-instant transfers. Built with compliance in mind, the platform enforces KYC-verified accounts, transparent transaction fees, and private, auditable governance, while also fostering automation through programmatic workflows and integration with familiar developer tools like Python-based smart contracts. CE reactions and institutional testing underscore its real-world applicability; CME Group is piloting GCUL for tokenized settlement workflows in areas like collateral and margin processing.
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