ZSegment is a cloud-native interface engine built by 314e Corporation, designed to seamlessly connect and integrate clinical, financial, and administrative systems across healthcare organizations. It offers more than 300 components, supports real-time metrics based on open telemetry standards, and is constructed on a Kubernetes-native architecture using Apache Camel to enable scalability, flexibility and developer-friendly customization including version control (Git), native custom schema support for HL7 v2, FHIR, X12 and CCD, visual tools for message routing, Groovy scripting for transformations, and secure message delivery over multiple protocols (File, FTP, HTTP(S), TCP). It also features message indexing, tracing, editing/resubmission, and custom job definitions for data hygiene and operational monitoring. ZSegment is positioned as a modern alternative to legacy on-premise interface engines like Mirth Connect, alleviating hardware procurement costs, expensive licensing, etc.