Best Extended Detection and Response (XDR) Platforms for Microsoft 365

Compare the Top Extended Detection and Response (XDR) Platforms that integrate with Microsoft 365 as of October 2025

This a list of Extended Detection and Response (XDR) platforms that integrate with Microsoft 365. Use the filters on the left to add additional filters for products that have integrations with Microsoft 365. View the products that work with Microsoft 365 in the table below.

What are Extended Detection and Response (XDR) Platforms for Microsoft 365?

Extended detection and response (XDR) platforms enable organizations to discover and address cybersecurity incidents across disparate hybrid systems such as networks, applications, endpoints, and the cloud. Compare and read user reviews of the best Extended Detection and Response (XDR) platforms for Microsoft 365 currently available using the table below. This list is updated regularly.

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    Blumira

    Blumira

    Blumira

    Empower Your Current Team to Achieve Enterprise-Level Security with Blumira XDR An all-in-one XDR solution with SIEM, endpoint visibility, 24/7 monitoring, and automated response to reduce complexity, increase visibility and speed up time to respond. We handle the security heavy lifting, so you get time back in your day. An XDR with out-of-the-box detections, pre-filtered alerts, and response playbooks, IT teams can achieve real security value with Blumira. Quick Deployment, Immediate Results: the XDR integrates with your tech stack and fully deploy, with no warm-up period, in hours All-You-Can-Eat Data Ingest: Predictable pricing and with unlimited data logging for an XDR with full-lifecycle detection Compliance Made Easy: 1 year data retention included, pre-built reports, and 24/7 automated monitoring 99.7% CSAT Support: Solution Architects for product support, the Incident Detection and Response Team creating new detections, and 24/7 SecOps support
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  • 2
    IBM QRadar SIEM
    Market-leading SIEM built to outpace the adversary with speed, scale and accuracy As digital threats loom large and cyber adversaries grow increasingly sophisticated, the roles of SOC analysts are more critical than ever. Going beyond threat detection and response, QRadar SIEM enables security teams face today’s threats proactively with advanced AI, powerful threat intelligence, and access to cutting-edge content to maximize analyst potential. Whether you need cloud-native architecture built for hybrid scale and speed or a solution to complement your on-premises infrastructure, IBM can provide you with a SIEM to meet your needs. Experience the power of IBM enterprise-grade AI designed to amplify the efficiency and expertise of every security team. With QRadar SIEM, analysts can reduce repetitive manual tasks like case creation and risk prioritization to focus on critical investigation and remediation efforts.
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    Microsoft Defender XDR
    Microsoft Defender XDR is an industry-leading extended detection and response (XDR) platform that provides unified investigation and response capabilities across various assets, including endpoints, IoT devices, hybrid identities, email, collaboration tools, and cloud applications. It offers centralized visibility, powerful analytics, and automatic cyberattack disruption to help organizations detect and respond to threats more effectively. By integrating multiple security services, such as Microsoft Defender for Endpoint, Microsoft Defender for Office 365, Microsoft Defender for Identity, and Microsoft Defender for Cloud Apps, it enables security teams to correlate signals across these services, providing a comprehensive view of threats and facilitating coordinated responses. This integration allows for automatic actions to prevent or stop attacks and self-heal affected assets, enhancing overall security posture.
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    Microsoft Defender for Office 365
    Protect all of Office 365 against advanced threats, such as phishing and business email compromise. Boost productivity, simplify administration, and reduce the total cost of ownership with built-in protection against advanced threats. Improve SecOps efficiency with unparalleled scale and effectiveness using automated workflows. Help protect your organization from attacks across the kill chain with a complete solution for collaboration. Help prevent a wide variety of volume-based and targeted attacks, including business email compromise, credential phishing, ransomware, and advanced malware with a robust filtering stack. Detect malicious and suspicious content like links and files across Office 365, all using industry-leading AI. Track attacks across Office 365 with advanced hunting capabilities that help identify, prioritize, and investigate threats. Amplify your security team’s effectiveness and efficiency with extensive incident response and automation capabilities.
    Starting Price: $2 per month
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    Defense.com

    Defense.com

    Defense.com

    Take control of cyber threats. Identify, prioritize and track all your security threats with Defense.com. Simplify your cyber threat management. Detection, protection, remediation, and compliance, are all in one place. Make intelligent decisions about your security with automatically prioritized and tracked threats. Improve your security by following the effective remediation steps provided for each threat. Gain knowledge and advice from experienced cyber and compliance consultants when you need assistance. Take control of your cyber security with easy-to-use tools that can work with your existing security investment. Live data from penetration tests, VA scans, threat intelligence and more all feeds into a central dashboard, showing you exactly where your risks are and their severity. Remediation advice is included for each threat, making it easy to make effective security improvements. Powerful threat intelligence feeds are mapped to your unique attack surface.
    Starting Price: $30 per node per month
  • 6
    ESET PROTECT Elite
    ESET PROTECT Elite is an enterprise-grade cybersecurity solution that integrates extended detection and response with comprehensive multilayered protection. It offers advanced threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent zero-day threats and ransomware. The platform includes modern endpoint protection for computers and smartphones, server security for real-time data protection, and mobile threat defense. It also features full disk encryption, helping organizations comply with data protection regulations. ESET PROTECT Elite provides robust email security, including anti-phishing, anti-malware, and anti-spam technologies, along with cloud app protection for Microsoft 365 and Google Workspace. Vulnerability and patch management capabilities allow for automatic tracking and patching of vulnerabilities across all endpoints.
    Starting Price: $275 one-time payment
  • 7
    Vectra AI
    Vectra enables enterprises to immediately detect and respond to cyberattacks across cloud, data center, IT and IoT networks. As the leader in network detection and response (NDR), Vectra uses AI to empower the enterprise SOC to automate threat discovery, prioritization, hunting and response. Vectra is Security that thinks. We have developed an AI-driven cybersecurity platform that detects attacker behaviors to protect your hosts and users from being compromised, regardless of location. Unlike other solutions, Vectra Cognito provides high fidelity alerts instead of more noise, and does not decrypt your data so you can be secure and maintain privacy. Today’s cyberattacks will use any means of entry, so we provide a single platform to cover cloud, data center, enterprise networks, and IoT devices, not just critical assets. The Vectra NDR platform is the ultimate AI-powered cyberattack detection and threat-hunting platform.
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    The Respond Analyst
    Accelerate investigations and improve analyst productivity with a XDR Cybersecurity Solution. The Respond Analyst™, an XDR Engine, automates the discovery of security incidents by turning resource-intensive monitoring and initial analysis into thorough and consistent investigations. Unlike other XDR solutions, the Respond Analyst connects disparate evidence using probabilistic mathematics and integrated reasoning to determine the likelihood that events are malicious and actionable. The Respond Analyst augments security operations teams by significantly reducing the need to chase false positives resulting in more time for threat hunting. The Respond Analyst allows you to choose best-of-breed controls to modernize your sensor grid. The Respond Analyst integrates with the leading security vendor offerings across important categories such as EDR, IPS, Web Filtering, EPP, Vulnerability Scanning, Authentication, and more.
  • 9
    Cisco SecureX
    SecureX is a cloud-native, built-in platform that connects our Cisco Secure portfolio and your infrastructure. It allows you to radically reduce dwell time and human-powered tasks. Achieve simplicity, visibility, and efficiency by removing bottlenecks that slow down your teams' access to answers and actions. SecureX includes XDR capabilities and beyond with every Cisco Secure product. Get an integrated and open platform that simplifies your existing ecosystem and works with third-party solutions. Experience unified visibility with a customizable dashboard and maintain context around incidents with a consistent ribbon that never leaves you. Accelerate threat investigations and incident management by aggregating and correlating global intelligence and local context in one view. Automate routine tasks using prebuilt workflows that align to common use cases. Or build your own workflows with our no-to-low code, drag-and-drop canvas.
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    Optiv Managed XDR
    Attackers are stealthy, relentless and motivated, and might use the same tools you do. They hide in your environment and quickly expand access. We understand the cyber ecosystem because it’s where we live, it’s where we operate. Our MXDR solution’s secret sauce derives from that pedigree, tested processes, proven IP, best-of-breed technology, leveraged automation and providing top-shelf talent to manage it all. Let’s collaborate and develop a custom solution with comprehensive threat visibility, accelerated incident identification, investigation, triage and mitigation actions to protect your enterprise from attacks and threats. We’ll start with your existing investments in endpoint, network, cloud, email and OT/IoT tools. Our experts will get those on the same team, actual technology orchestration! Reduces the attack surface, detects threats faster and automates deep investigation through a continuous approach.
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    Cybraics

    Cybraics

    Cybraics

    Stop chasing alerts and prevent incidents before they happen with the world's leading XDR platform that revolutionizes threat detection, log management, and response. Close the gaps and free your team with our silo-breaking, enterprise-class industry-leading XDR platform that covers compliance and simplifies security operations. Cybraics nLighten™ isn't just another security tool. Born out of AI and machine learning research with the U.S. Department of Defense, it's the catalyst to unlock actionable intelligence from the scattered and siloed data, logs, and alerts across multiple security tools in your network. And with Cybraics, powerful threat detection doesn't need to come at a premium. Powered by Adaptive Analytic Detection (AAD) and Persistent Behavior Tracing (PBT). Maximize security team efficacy with 96% automated actionable case creation and a 95% reduction in false positives. Reduce detection and response time from months to minutes.
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    Rotate

    Rotate

    Rotate

    Use the Rotate cloud security platform to secure any business with modular hubs and seamless integrations designed to scale your security needs. Gain greater context on cyberattacks and improve remediation by identifying alerts across all hubs, correlating them, and prioritizing incidents by risk level. Synthesize, consolidate, and manage all hubs in Rotate’s XDR. Use your multi-tenancy control center for vulnerability scans and rapid deployments. Manage unlimited clients through a single pane of glass. Empower your business customers with a complete cybersecurity solution and reduce portfolio risk. Rotate protects all types of organizations in the new world of digital-first work. Get complete cybersecurity for every employee who uses email or brings a device to work. Cyber insurance is essential for any organization at risk of a cyber attack, but coverage can be expensive. Comprehensive protection like the type provided by Rotate can help reduce the overall cost of insurance.
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    Obsidian Security

    Obsidian Security

    Obsidian Security

    Protect your SaaS applications against breaches, threats, and data exposure. Start in minutes and secure Workday, Salesforce, Office 365, G Suite, GitHub, Zoom and other critical SaaS applications with data-driven insights, monitoring, and remediation. Companies are moving their critical business systems to SaaS. Security teams lack the unified visibility they need to detect and respond to threats quickly. They are not able to answer basic questions: Who can access SaaS apps? Who are the privileged users? Which accounts are compromised? Who is sharing files externally? Are applications configured according to best practices? It is time to level up security for SaaS. Obsidian delivers a simple yet powerful security solution for SaaS applications built around unified visibility, continuous monitoring, and security analytics. With Obsidian, security teams are able to protect against breaches, detect threats, and respond to incidents in their SaaS applications.
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