Best Email Security Software for Microsoft 365
View:
Compare the Top Email Security Software that integrates with Microsoft 365 as of October 2025
Sort By:
This a list of Email Security software that integrates with Microsoft 365. Use the filters on the left to add additional filters for products that have integrations with Microsoft 365. View the products that work with Microsoft 365 in the table below.
What is Email Security Software for Microsoft 365?
Email security software protects organizations from cyber threats such as phishing, malware, and spam by filtering incoming and outgoing email traffic. It uses advanced threat detection, encryption, and data loss prevention (DLP) to safeguard sensitive information. These tools also offer features like email authentication (DMARC, SPF, DKIM) and real-time threat intelligence to block emerging attacks. By securing email communications, businesses can prevent data breaches, ensure regulatory compliance, and maintain user trust. Email security software is essential for mitigating human error, which is one of the leading causes of data breaches. Compare and read user reviews of the best Email Security software for Microsoft 365 currently available using the table below. This list is updated regularly.
-
1
Guardz
Guardz
Guardz is the unified cybersecurity platform purpose-built for MSPs. We consolidate the essential security controls, including identities, endpoints, email, awareness, and more, into one AI-native framework designed for operational efficiency. Our identity-centric approach connects the dots across vectors, reducing the gaps that siloed tools leave behind so MSPs can see, understand, and act on user risk in real time. Backed by an elite research and threat hunting team, Guardz strengthens detection across environments, turning signals into actionable insights. With 24/7 AI + human-led MDR, Guardz utilizes agentic AI to triage at machine speed while expert analysts validate, mitigate, and guide response, giving MSPs scalable protection without adding headcount. Our mission is simple: give MSPs the scale, confidence, and clarity they need to stay ahead of attackers and deliver protection to every SMB they serve. -
2
SpamTitan
TitanHQ
SpamTitan email security is an email spam filter for businesses, smbs, MSPs, and schools. SpamTitan email security blocks spam as well as phishing and day-zero attacks, viruses, malware, ransomware, and other email threats. Helps control mail flow, clean it, and protect against unwanted email. We provide easy-to-use yet advanced email security for businesses, smbs and MSPs that are Office365 friendly. SpamTitan - Premium functionality included: • CEO Impersonation protection • Phishing/ Spear phishing protection • Link analysis • Full Sandboxing • Zero Day Attacks protection • Mail Spooling • Spoofing protection • Malware and Ransomware protection • SPF/DKIM/DMARC checking • Encryption • Fully multitenant environment • Ability to rebrand the entire UI • Full REST API: • Comprehensive support and set up docs Try a FREE, fully supported trial of SpamTitan Email Security today.Starting Price: $2.14/user/month -
3
NeoCertified Secure Email
NeoCertified
NeoCertified protects sensitive information through our secure email application across our versatile Cloud-based platform on any web browser, through Microsoft Office 365/Outlook plug-ins, and Gmail integration. iPhone + Android mobile apps are also available directly on your mobile devices. We have provided federally compliant, secure email solutions since 2002, and have helped businesses send and receive secure emails on any web browser or mobile device. NeoCertified also works across all email providers to give businesses the flexibility and assured protection they desire and deserve.Starting Price: $99.00/year/user -
4
Easy365Manager
Agema A/S
Remove all pain from Office 365 management. Manage everything from AD Users & Computers. Eliminate Exchange on-premises. Easy365Manager integrates Office 365 with AD management, eliminating the need to constantly log in to web consoles and run PowerShell. Easy365Manager extends the functionality of AD Users & Computers by adding two new tabs to user properties. This allows you to manage EXO mailboxes directly from AD user properties - even complex settings like calendar delegation that otherwise require complex PowerShell scripting. Easy365Manager will allow your first-level supporter to work lightning-fast and reduce the number of tickets that are escalated to senior admins. Easy365Manager installs to any PC or server that has AD Users & Computers. There is no server component, service, AD extension, or custom security layer. You can install and configure Easy365Manager in less than two minutes and instantly eliminate all pain from hybrid Office 365 Management.Starting Price: $84 per year -
5
FileWall
Odix
odix - a market leader in Enterprise CDR (Content Disarm and Reconstruction), is now offering FileWall, a native cybersecurity application for Microsoft Office 365 mailboxes for SMEs. FileWall™ is designed to run in conjunction with existing Microsoft security solutions such as EOP and ATP, ensuring complete prevention against unknown attacks delivered via email attachments. FileWall™ doesn’t harm/change any of Microsoft sender related security capabilities.Starting Price: $1 per user, per month -
6
N-able Mail Assure
N-able
N-able Mail Assure cloud-based email security solution provides advanced threat protection for inbound and outbound email using collective threat intelligence, 24/7 email continuity, and long-term email archiving. The service includes a multitenant web-interface with predefined settings, reporting, and views designed to ensure control and visibility over email flows. N-able Mail Assure’s proprietary technology incorporates input from processing large volumes of email data that feeds the Intelligent Protection and Filtering Engine. This combined with real-time pattern threat recognition leveraging a variety of filtering technologies help protect against spam, viruses, phishing attacks, impersonation, spoofing, malware, and other email-borne threats. -
7
365 Total Protection
Hornetsecurity
365 Total Protection from Hornetsecurity offers comprehensive protection for Microsoft cloud services – specially developed for Microsoft 365 and seamlessly integrated to provide comprehensive protection for Microsoft cloud services. Easy to set up and extremely intuitive to use, 365 Total Protection simplifies your IT Security management from the very start. Protect your Microsoft 365 against phishing, ransomware, advanced threats and data loss with 365 Total Protection Enterprise Backup, a unique cloud-based, all-in-one security and backup suite. Benefit from the expertise of Hornetsecurity, leading email security and backup specialists, known for their tried and tested, award-winning solutions, 365 Total Protection (email security for M365) and 365 Total Backup (backup and recovery for M365). -
8
PhishTitan
TitanHQ
Powerful Inline Phishing Protection for M365. Harness the power of AI and our LLM to defeat phishing. PhishTitan is next generation inline phishing protection and remediation, powered by TitanHQ, the global leaders in email cybersecurity. Our proprietary large learning model and AI integrates directly with Microsoft 365, both catching and remediating sophisticated phishing and BEC attacks that Microsoft misses. It provides users with in-the-moment warning banners to help them decide whether an email is malicious or safe, continually enhancing the human firewall. Risk free deployment in 6 minutes. PhishTitan will filter your email to identify phishing threats and protect your users and business. That’s how you AVOID that one wrong click that can lead to disaster – all it takes is 6 minutes! The TitanHQ team has been a category leader in the email security field for over 20 years. Bringing the experience of working with over 12,000 customers to our new phishing solution. -
9
Advanced protection to safeguard your inboxes. Email is still the No. 1 threat vector. Expand the scope of your defenses to detect dangerous threats and rapidly respond to and remediate new threats in real time. Identify the malicious techniques used in attacks targeting your organization. Understand the specific business risks and categorize threats to gain insight into the parts of your organization that are most vulnerable to attack. AI-driven threat detection uses multiple detection engines to simultaneously evaluate different portions of an incoming email. These verdict details help ensure accurate threat classification, identify business risk, and promote an appropriate response action. Threats come from numerous sources: phishing, business email compromise, malware, and ransomware. Defend against all of them with industry-leading threat intelligence that empowers you to act quickly.
-
10
SecurityGateway™ for Email Servers
MDaemon Technologies
Developed by MDaemon Technologies, an email industry pioneer, Security Gateway's email threat detection technology has been protecting email servers from viruses, spam, phishing, data loss and other threats for over 20 years. Simply put, companies trust our expertise to help keep email communications safe. We protect all email platforms including Microsoft Exchange, Office 365 and others. Let our team of email security experts take the headache out of managing your company's email security needs. Security Gateway uses the latest email threat detection technology and policy enforcement tools to keep good emails flowing to and from your users. The Security Gateway cloud service can be deployed quickly and easily, allowing you to focus on other important tasks. Watch a short video to learn about some of the Security Gateway features.Starting Price: $1 per user per month -
11
Hornetsecurity Advanced Threat Protection
Hornetsecurity
With the comprehensive features of Advanced Threat Protection, even the most sophisticated cyber-attacks have no chance: Freezing, URL scanning and rewriting, the Sandbox Engine and Malicious Document Decryption are able to cope with a multitude of methods in order to ward off all potential threats. Thus protecting your IT infrastructure from threats like Ransomware, Targeted Attacks, Business Email Compromise and many more. -
12
MailRoute
MailRoute
Stop Ransomware, spam and phishing, other viruses and threats for SMB, Enterprise, Healthcare, and Government agencies and contractors. API-level integration for Microsoft Office 365 & GCC High, Google Workplace, other email hosts and all servers. MailRoute stops email-instigated attacks on your information and hardware, with cost-effective, multi-layered protection. We offer CMMC, NIST 800-171, HIPAA, DFARS compliant and DISA accepted email security services. No single point of failure. Wholly owned solution includes geo-distributed datacenters with redundant network feeds, power sources and cooling, for 99.999% uptime. MailRoute prevents forgeries and email spoofing by identifying malicious messages with email authentication tools through assisted and managed DNS changes. Continually managed and updated email-network security stops cybercrime and threats like downtime, ensuring cost-predictability and reliability.Starting Price: $2 per user per month -
13
Varonis Data Security Platform
Varonis
The most powerful way to find, monitor, and protect sensitive data at scale. Rapidly reduce risk, detect abnormal behavior, and prove compliance with the all-in-one data security platform that won’t slow you down. A platform, a team, and a plan that give you every possible advantage. Classification, access governance and behavioral analytics combine to lock down data, stop threats, and take the pain out of compliance. We bring you a proven methodology to monitor, protect, and manage your data informed by thousands of successful rollouts. Hundreds of elite security pros build advanced threat models, update policies, and assist with incidents, freeing you to focus on other priorities. -
14
Symantec Email Security.cloud
Broadcom
Safeguard Microsoft Office 365, Google G Suite, and on-premises email with the industry’s most complete email security solution. Insulate users from spear phishing, credential theft and ransomware attacks by using Email Threat Isolation. Prevent insidious email threats such as spear phishing, ransomware, business email compromise and email spam. Stop spear phishing emails with multiple layers of protection, threat isolation, spam filtering, advanced security email analytics, built-in user awareness, education tools, and more. Block the latest ransomware with content defense, sandboxing, and link protection technologies that detect emerging, stealthy, and zero-day attacks. Defeat business email compromise with impersonation protection, sender authentication enforcement and brand protection controls. Protect your brand reputation by using automation to solve the practical issues of enforcing sender authentication (DMARC, DKIM and SPF) with Symantec Email Fraud Protection. -
15
Xink
Xink
Manage Microsoft 365 or Google Workspace email signatures in one place with Xink's powerful web portal - built on a decade of experience with email signature management. Get consistent, branded and up-to-date signatures for all employees across devices, departments, and geography. Create customized and targeted email signature marketing banners below the contact details to share updates, achievements, values, promote content and much more! All with clickable call-to-actions to help you drive traffic and interest. With role-based login, the marketing or communications department can easily manage it. After the initial setup (45 min), IT has no workload. Safely hosted at ISO 27001-certified data centers (Microsoft Azure). This ensures the best, most secure data storage available – under all laws and regulations, including GDPR.Starting Price: $1/user/month -
16
Spambrella
Spambrella
Dynamically classify imposter email. Preemptively identify and sandbox suspicious URLs. Leverage big-data analysis to accurately classify bulk mail. All within a single service that connects with Microsoft 365 and Google Workspace. Spambrella’s Email Security and User Awareness Training technology is used by some of the World’s largest and most successful security-conscious companies in a multitude of continents and environments. Delivered on a global scale, Spambrella is ready to unify your email security and user awareness training requirements. Think of us as your outsourced email security team! We have deep technical expertise of all other service providers such as MxLogic, Mimecast, Symantec.cloud and know how to migrate you effortlessly. Schedule a demo today with our cybersecurity experts to uncover email threats targeting your email users.Starting Price: $1.00 -
17
Guardian Digital
Guardian Digital
Guardian Digital secures against email threats like phishing, zero-day exploits and ransomware attacks that define the modern threat landscape email users face every day. We believe email security is business security, as greater than 90% of all cyber attacks originate from an email. The most effective email protection is delivered through a purpose-driven solution designed to close critical security gaps in Microsoft 365 and Workspace, coupled with the expert setup, ongoing remote system management and accessible support required to improve IT security. With real-time cybersecurity business insights, we help you understand what your risk profile is today, and protect you from the dangers that all businesses face. EnGarde Cloud Email Security - Key Features: • Phishing, spoofing & impersonation protection • Link & file analysis • Zero-day attack protection • Malware & Ransomware protection • SPF/DKIM/DMARC checking • Encryption • Comprehensive management & support serviceStarting Price: Monthly & Annual Subscriptions -
18
dmarcian
dmarcian
Our DMARC management platform visualizes DMARC data in powerful and meaningful ways so you can quickly identify authentication gaps with your SPF and DKIM configurations, as well as unauthorized use of your domains. In addition to aggregating DMARC data, our platform provides domain administration teams with the necessary features to adopt DMARC with clarity and confidence. Providing actionable insights, it is powered by the most accurate source classification engine in the industry and affords users with assurances of the true origin of a particular mail stream. dmarcian has been processing DMARC data since the inception of the specification in 2012. -
19
LuxSci
Lux Scientiae
LuxSci provides HIPAA-compliant web and email communications services. LuxSci creates uniquely secure and customizable enterprise-grade environments and solutions that enable organizations to confidently meet their specific business and security needs at scale. LuxSci’s HIPAA-compliant email and web solutions are HITRUST certified and include: • Secure High Volume Sending for delivering massive volumes of transactional and marketing emails. • Secure SMTP Connector for encrypting outbound emails sent from Microsoft 365 and Google Workspace. • Secure Email Marketing platform for creating and sending marketing campaigns with ePHI. • Secure Email Hosting for reliable and secure day-to-day business email. • Fully managed Secure Web and Database Hosting for web applications that require compliance. • Secure Forms to safely collect and store sensitive information. LuxSci provides a full suite of secure technology for companies requiring compliant web and email services.Starting Price: $4 per/user/month -
20
PhishProtection
DuoCircle
Make your smartest investment to reduce email security threats today, and get a comprehensive email security protection solution with small business pricing. Cybercriminals are targeting CEOs, CFOs, HR, Accounting Departments and regular employees across every industry. As you know Office 365 is extremely limited in the protection that you can configure to stop impersonations, email fraud and phishing. There are only so many custom transport rules you can build to constantly block domains or protect against employee impersonations. PhishProtection works on every email server, device or smtp service. No matter if you are on your phone, or outlook or any email client anywhere, we can protect you. It offers best-in-class security to iOS and Android devices alike.Starting Price: $100/month/user -
21
Additional layer of security to stop threats from ever reaching users in the network. Designed to protect email communication, the most vulnerable vector. ESET features a true 64-bit product that allows for clustering to ensure that speed is never a concern for organizations of any size. ESET Mail Security solutions use in-house developed anti-spam, anti-phishing and host server protection, combining machine learning, big data and human expertise into one award-winning mail security platform. Helps eliminate unsolicited emails and targeted attacks, allowing employees to focus on their job and ensure business continuity. Users are constantly targeted via phishing campaigns that may contain other malicious components. A single user will not be efficient due to having to sift through whether emails are legitimate or not. Emails are automatically provided to users about their spam emails that were quarantined.Starting Price: $132 per 5 devices per year
-
22
Preventive protection for cloud-based applications such as email, collaboration, and storage. A powerful combination of spam filtering, anti‑malware scanning, anti‑phishing, and advanced threat defense capabilities. Equip your Microsoft 365 Exchange Online, OneDrive, Teams, and SharePoint Online with an extra layer of advanced protection. Helps eliminate unsolicited emails, targeted attacks, and ransomware, allowing employees to focus on their jobs and ensure business continuity. Get immediate notifications direct to your dedicated console, or via alerts. New users are protected automatically. Provides advanced protection for Microsoft 365 applications against malware, spam, or phishing attacks with ultimate zero-day threat defense and an easy-to-use cloud management console. Now using an enhanced, award-winning engine with improved performance, this essential component filters all spam emails and keeps user mailboxes free of unsolicited or undesired messages.Starting Price: $119.50 per year
-
23
Raptor Email Security
Peregrine Computer Consultants Corporation
Raptor Email Security is an MX-based email security solution designed by industry experts to stop spam, phishing, and malware attacks using a unique scoring framework and multiple technologies including SpamAssassin, ClamAV, MIMEDefang, and Sendmail. Let our experts handle the annoying spam for you! No Spam. Zero Tickets. 2X Resources. With your email going through our servers, we handle the brunt of most cyber attacks which keeps your server better protected! With less resource usage, you'll be able to increase your hosting revenue and monetize your server by adding more hosting accounts. Raptor Email Security also comes with Raptor Review which provides a detailed, expert analysis of your email configuration. It's a phishing hotline and white glove service to definitively fix your email problems including blocking spam, improving email deliverability, identifying scams, finding missing email, and unblocking good email. Set up in minutes. Free 30 Day Trial Available!Starting Price: $15/server/month -
24
Mailock
Beyond Encryption
Mailock secure email empowers companies to exchange sensitive information with customers, without risking their data. It combines award-winning encryption technology with multi-factor identity authentication to protect confidential emails from cyber risk and keep customer information protected. Compose a secure email from your desktop, browser, or use rules and keywords to initiate the encryption. Set authentication challenges to verify your recipients’ identity so only the right people gain access. Keep audit trails for every message and track your recipients’ activity with real-time read notifications. Recipients can encrypt their replies for free. Empower your customers with a secure thread to your business. Deliver confidential documents to your customers at high volume with automated secure email delivery.Starting Price: $9.30 per user per month -
25
VIPRE SafeSend
VIPRE Security Group
Protect your organization from accidental data breaches with VIPRE SafeSend, the ultimate safeguard for Microsoft Outlook. SafeSend prompts users to confirm external recipients and attachments before sending emails, reducing the risk of misaddressed messages. Unlike traditional Data Loss Prevention (DLP) solutions that simply block emails after they’re sent—adding strain to already overstretched security teams—SafeSend proactively empowers employees to recognize and prevent mistakes in real time. It also scans outgoing emails and attachments to ensure sensitive data stays within your network. Over time, users develop better email habits, enhancing your organization’s security posture. Choose from two tailored packages: one focused on preventing misaddressed emails and another designed to meet comprehensive DLP requirements. With VIPRE SafeSend, you’re not just protecting data—you’re building a smarter, more security-conscious workforce.Starting Price: $30/user/year -
26
Keepnet Labs
Keepnet Labs
Keepnet’s extended human risk management platform empowers organizations to build a security culture with AI-driven phishing simulations, adaptive training, and automated phishing response, helping you eliminate employee-driven threats, insider risks, and social engineering across your organization and beyond. Keepnet continuously assesses human behaviors through AI-driven phishing simulations across email, SMS, voice, QR codes, MFA, and callback phishing to reduce human-driven cyber risks. Keepnet's adaptive training paths are tailored to individual risk levels, roles, and cognitive behaviors, ensuring that secure behaviors are embedded to continuously reduce human cyber risk. Keepnet empowers employees to report threats instantly. Using AI-driven analysis and automated phishing responses, security admins respond 168x faster. Detects employees who frequently click phishing links, mishandle data, or ignore security policies.Starting Price: $1 -
27
ESET PROTECT Elite
ESET
ESET PROTECT Elite is an enterprise-grade cybersecurity solution that integrates extended detection and response with comprehensive multilayered protection. It offers advanced threat defense using adaptive scanning, machine learning, cloud sandboxing, and behavioral analysis to prevent zero-day threats and ransomware. The platform includes modern endpoint protection for computers and smartphones, server security for real-time data protection, and mobile threat defense. It also features full disk encryption, helping organizations comply with data protection regulations. ESET PROTECT Elite provides robust email security, including anti-phishing, anti-malware, and anti-spam technologies, along with cloud app protection for Microsoft 365 and Google Workspace. Vulnerability and patch management capabilities allow for automatic tracking and patching of vulnerabilities across all endpoints.Starting Price: $275 one-time payment -
28
Avanan
Check Point
Enterprise AI cloud security: prevent phishing, malware, data leakage, account takeover, & shadow IT for full-suite cloud applications like Office 365™. Default security misses far too many malicious emails, necessitating advanced email security to protect the enterprise. Avanan reinvented email security in 2015 because traditional gateways couldn’t, and haven’t, adjusted to the cloud. Avanan’s patented security. Security for all your collaboration apps. Ransomware, account takeover, BEC, supply chain attacks. 99.2% reduction in phishing attacks reaching the inbox. Avanan is powered by True AI, trained on comprehensive data sets to stop the most sophisticated phishing attacks before they reach the inbox. To implement API, machine learning and AI for cloud email security. 5,000+ customers, 60% coming from large enterprise. Ranked Email Security solution in Gartner Peer Insights and G2. -
29
MailList King
Xequte Software
MailList King brings all the power of a mailing list server to your PC, in an easy-to-use solution that allows you to create, manage and communicate with the people interested in your web site, products or organization. MailList King integrates with all popular E-mail software (such as Outlook, Gmail, etc) or directly with your mail servers to retrieve mailing list messages (subscribes, unsubscribes, undeliverable messages, etc) and deliver processing acknowledgments, double opt-in confirmations and the personalized, rich text messages that you create. If you are trying to manage a mailing list in Excel or Outlook Contacts then MailList King can save you time and money by automatically handling the addition and deletion of people. You can concentrate on creating compelling newsletters and powerful sales messages and let MailList King do the hard work. You don't need to be a computer expert to use MailList King.Starting Price: $99.50 one-time payment -
30
M365 Manager Plus is an extensive Microsoft 365 tool used for reporting, managing, monitoring, auditing, and creating alerts for critical activities. With its user-friendly interface, you can easily manage Exchange Online, Azure Active Directory, Skype for Business, OneDrive for Business, Microsoft Teams, and other Microsoft 365 services all from one place. M365 Manager Plus provides exhaustive preconfigured reports on Microsoft 365 and helps you perform complex tasks including bulk user management, bulk mailbox management, secure delegation, and more. Monitor Microsoft 365 services around the clock, and receive instant email notifications about service outages. M365 Manager Plus eases compliance management with built-in compliance reports and offers advanced auditing and alerting features to keep your Microsoft 365 setup secure.Starting Price: $345 per year