Matrix Req vs. Orthogonal Comparison


Matrix Req Matrix One	Orthogonal	+	+
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		Related Products Jama Connect Jama Software® is focused on maximizing innovation success in multidisciplinary engineering organizations. Numerous firsts for humanity in fields such as fuel cells, electrification, space, software-defined vehicles, surgical robotics, and more all rely on Jama Connect® requirements management software to minimize the risk of defects, rework, cost overruns, and recalls. Using Jama Connect, engineering organizations can now intelligently manage the development process by leveraging Live Traceability™ across best-of-breed tools to measurably improve outcomes. Our rapidly growing customer base spans the automotive, medical device, life sciences, semiconductor, aerospace & defense, industrial manufacturing, consumer electronics, financial services, and insurance industries. 416 Ratings Visit Website Qualio Qualio is the leading quality and compliance platform built exclusively for emerging life sciences companies. MedTech, pharma, biotech, and diagnostics teams use Qualio to standardize quality processes, connect them to regulatory obligations, and gain real-time visibility into compliance health. With a modern eQMS at the core and Compliance Intelligence layered on top, Qualio helps teams get audit ready in weeks and stay audit ready forever — without spreadsheets, fire drills, or heavyweight GRC systems. What Qualio delivers: ✔️ Audit ready in weeks ✔️ Inspection ready anytime — no fire drills ✔️ Faster market entry ✔️ Lower total cost of compliance ✔️ Confident, risk-managed scaling 919 Ratings Visit Website Propel Propel is a cloud-native platform that unifies PLM, QMS, and PIM in one connected system, giving manufacturers complete visibility and control across the entire product lifecycle. It provides a single source of truth for product data, streamlines change management, strengthens quality and compliance, and accelerates time-to-market by eliminating silos. With real-world AI use cases and enterprise-grade security, Propel helps organizations reduce errors and improve cross-functional alignment. Agentic AI accelerates change reviews, surfaces BOM and quality risks, enriches product information, and guides decisions—while role-based permissions and audit trails protect IP. From design through manufacturing and commercialization, Propel empowers companies to deliver innovative, high-quality products faster with greater confidence. Each module deploys independently with no required dependencies. 215 Ratings Visit Website Lockbox LIMS A sample tracking, test result capture, and inventory management cloud LIMS for life science research, biotech/NGS, and industrial QC labs. Includes regulatory support for CLIA, HIPAA, Part 11, and ISO 17025. Nothing is more critical to a lab’s success than the quality, security, and traceability of samples. The Lockbox LIMS system provides robust sample management functionality to laboratory professionals, giving them full visibility on every aspect of a sample’s journey, from accessioning to long-term storage. LIMS analysis is about more than just tracking results- Lockbox’s multi-layered sample storage and location management functionality allows you to define your lab’s storage framework using a variety of location options: rooms, storage units, shelves, racks, boxes, and positions. 72 Ratings Visit Website MedTrainer MedTrainer accelerates and simplifies healthcare workforce education, compliance, and credentialing. MedTrainer’s natively built software platform provides a seamless user experience that helps healthcare organizations thrive in managing their workforce. Learning: A healthcare-specific learning management system (LMS) enriched with thousands of education courses and resources created by subject matter experts to satisfy regulatory, accreditation requirements, and provide continuing education credit. Compliance: A technology solution that combines incident reporting, document, and policy management, and highly customizable reports to improve compliance. Credentialing: An end-to-end credentialing capability with automation, workflows, and centralized data to simplify the process and reduce costly delays. From PSV to provider enrollment and privileging, everything is in one platform with complete visibility. 250 Ratings Visit Website MedRight MedRight is a dynamic, user friendly, secure, cost effective software platform for use in Assisted Living communities, Residential Treatment Centers, IDD facilities, and Group Homes. MedRight improves patient safety, reduces medication errors, and is fully HIPAA compliant. Years of product enhancements and new features based on actual community use have resulted in a powerful, fully integrated software suite that users love. MedRight has it all to manage any senior living community, including the ability to work without a network connection in case the internet is down. Modules include marketing (CRM), e-prescribing, inventory, pharmacy integration, care plans, assessments, e-Narcotic logs, ADLs, billing, and resident and staff management. Let MedRight reduce your risk, improve your bottom line, and streamline your operations, while you spend more time with your residents! 22 Ratings Visit Website Innoslate SPEC Innovations’ flagship model-based systems engineering solution can help your team reduce time-to-market, cost, and risk on even some of the most complex systems. This cloud or on-premise application uses a modern web browser, with an intuitive graphical user interface. Innoslate’s full lifecycle capabilities include: • Requirements Management • Documents Management • Modeling • Discrete Event Simulator • Monte Carlo Simulator • DoDAF Models and Views • Database Management • Test Management with full reports, status updates, results, and more. • Real Time Collaboration 98 Ratings Visit Website Process Street Process Street is an AI-powered compliance operations platform that automates complex workflows, enforces standards, and tracks audit data in real time. Teams use it to create structured SOPs, assign tasks, collect data, and monitor execution with intelligent oversight. From onboarding and audits to vendor management and document control, Process Street ensures every step is followed and every action is logged. Built for regulated industries like financial services, healthcare, and manufacturing, it supports frameworks such as ISO, SOC 2, SOX, and HIPAA. With role-based permissions, audit logs, and powerful integrations, Process Street replaces static documents, spreadsheets, and manual processes with a single automated system of record. Use AI to streamline approvals, catch risks early, and generate audit-ready evidence. Trusted by teams at Cargill, DoorDash, Farmers Insurance, and Hartford Healthcare. 1,119 Ratings Visit Website AlisQI AlisQI is a modular, cloud-based Quality Management platform for process and batch manufacturers who want to reduce firefighting, improve predictability, and stay compliant by default. Unlike traditional EQMS platforms that were built around documents and later adapted for analytics, AlisQI was designed from the start as a data-first system. Quality, lab, and production data are structured and connected in one operational backbone. That foundation now enables practical AI capabilities inside daily workflows. Manufacturers can automatically extract data from diverse supplier COAs without predefined templates, generate structured digital forms from existing files or plain language, query their QMS conversationally, and detect recurring incident patterns across sites. Core modules include Document Control, Training, Deviations, CAPA, Audits, Risk Management, Supplier Quality, SPC, and EHS, supported by targeted out-of-the-box Solvers that address specific operational problems. 108 Ratings Visit Website Interfacing Integrated Management System (IMS) Interfacing’s Integrated Management System (IMS) is an AI-powered platform that unifies BPM, QMS, Document Control, and GRC into one platform. Organizations use IMS to model and automate processes, control documents, manage risks, and maintain regulatory compliance with full traceability and audit readiness. Built for highly regulated sectors such as aerospace, life sciences, finance, and government, IMS provides real-time visibility, automated workflows, and AI-driven insights that improve quality and reduce operational risk. The platform is ISO 27001 certified and fully validated for 21 CFR Part 11, making it suitable for mission-critical environments requiring strong governance, security, and control. IMS also includes low-code automation, process mining, audit management, training tracking, CAPA workflows, and dashboards to help teams streamline operations and continuously improve. AI strengthens governance, improves accuracy, and reinforces regulatory control. 66 Ratings Visit Website
About Matrix Req (formerly Matrix Requirements) is a collaborative, AI-powered software explicitly built to meet the rigorous needs of medical device development. It helps cross-functional teams design, build, and launch high-quality medical devices while maintaining complete, end-to-end traceability of requirements, risks, and tests. The platform automates the cumbersome audit preparation process by generating structured documentation and trace matrices directly from live data, reducing regulatory submission timelines from weeks to days. Trusted by over 500+ life sciences companies, Matrix Req ensures that compliance is built-by-design rather than treated as an afterthought.	About Orthogonal provides specialized development services focused on building and scaling Software as a Medical Device (SaMD) and connected medical device systems, combining modern engineering practices with strict regulatory compliance. Their approach spans the full product lifecycle, including user experience design, human factors integration, requirements definition, risk analysis, Agile software development, and verification and validation to ensure both functionality and safety. It emphasizes the use of Agile methodologies adapted to regulated environments, enabling iterative development, faster feedback cycles, and continuous improvement while maintaining compliance with standards such as FDA, EU MDR, and ISO frameworks. Orthogonal supports the development of mobile, web, and desktop applications, cloud-based systems, AI algorithms, and SDKs that integrate with third-party platforms, allowing medical devices to connect, process data, and deliver insights.
Platforms Supported Windows Supported Mac Supported Linux Supported Cloud Supported On-Premises Supported iPhone Not Supported iPad Not Supported Android Not Supported Chromebook Supported	Platforms Supported Windows Not Supported Mac Not Supported Linux Not Supported Cloud Supported On-Premises Not Supported iPhone Not Supported iPad Not Supported Android Not Supported Chromebook Not Supported
Audience Medical device companies	Audience Medical device companies, digital health startups, and healthcare technology teams that need to develop compliant, scalable software for connected medical devices and digital therapeutics
Support Phone Support Supported 24/7 Live Support Supported Online Supported	Support Phone Support Not Supported 24/7 Live Support Not Supported Online Supported
API Offers API Supported	API Offers API Supported
Screenshots and Videos View more images or videos	Screenshots and Videos View more images or videos
Pricing $500 per month Free Version Supported Free Trial Supported	Pricing No information available. Free Version Not Supported Free Trial Not Supported
Reviews/Ratings Overall 0.0 / 5 ease 0.0 / 5 features 0.0 / 5 design 0.0 / 5 support 0.0 / 5 This software hasn't been reviewed yet. Be the first to provide a review: Review this Software	Reviews/Ratings Overall 0.0 / 5 ease 0.0 / 5 features 0.0 / 5 design 0.0 / 5 support 0.0 / 5 This software hasn't been reviewed yet. Be the first to provide a review: Review this Software

Training Documentation Supported Webinars Supported Live Online Supported In Person Supported	Training Documentation Supported Webinars Not Supported Live Online Not Supported In Person Not Supported
Company Information Matrix One Founded: 2016 United States, Germany, France, Belgium, United Kingdom matrixone.health/products/matrix-req	Company Information Orthogonal Founded: 2025 United States www.orthogonal.com
Alternatives QVscribe QRA	Alternatives SigmaXL
aligned elements Aligned AG	EagleView EagleView Technologies
Matrix Quality Matrix One	ZipQuality Consensia
Orcanos	STL Simple Viewer Victor Bovio
qmsWrapper View All	Orcanos View All
Categories Healthcare Compliance Supported Medical Quality Management Systems Supported Requirements Management Supported	Categories Agentic AI Supported
Show More Features Requirements Management Features Automated Functional Sizing Not Supported Automated Requirements QA Not Supported Automated Test Generation Not Supported Automated Use Case Modeling Not Supported Change Management Supported Collaboration Supported History Tracking Supported Prioritization Supported Reporting Supported Status Reporting Supported Status Tracking Supported Summary Reports Supported Task Management Supported To-Do List Not Supported Traceability Supported User Defined Attributes Supported
Integrations GitHub Supported AgentMail Not Supported Amazon Not Supported Andi Not Supported Apollo Not Supported Composio Not Supported Crustdata Not Supported Didit Not Supported Fiber AI Not Supported Fundable Not Supported GitLab Supported Klaus Not Supported Linkup Not Supported Matrix Quality Supported Notion Not Supported Olostep Not Supported ScrapeGraphAI Not Supported Slack Not Supported Tomba Not Supported YouTube Not Supported Show More Integrations View All 6 Integrations	Integrations GitHub Supported AgentMail Supported Amazon Supported Andi Supported Apollo Supported Composio Supported Crustdata Supported Didit Supported Fiber AI Supported Fundable Supported GitLab Not Supported Klaus Supported Linkup Supported Matrix Quality Not Supported Notion Supported Olostep Supported ScrapeGraphAI Supported Slack Supported Tomba Supported YouTube Supported Show More Integrations View All 37 Integrations
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