Best AI Security Software for Microsoft 365
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Compare the Top AI Security Software that integrates with Microsoft 365 as of August 2025
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This a list of AI Security software that integrates with Microsoft 365. Use the filters on the left to add additional filters for products that have integrations with Microsoft 365. View the products that work with Microsoft 365 in the table below.
What is AI Security Software for Microsoft 365?
AI security software is a technology that uses artificial intelligence (AI) to protect online systems from malicious attacks. AI security software can also ensure that companies are using AI software and generative AI tools safely. It can detect potential threats and blocks them before they cause damage. AI security software provides additional protection beyond traditional methods such as firewalls, antivirus, and intrusion detection systems. AI security software can be used to protect not only corporate networks but also individual computers from cyberattacks. The AI algorithms use machine learning techniques to learn about the changing patterns of malicious behavior in order to identify new threats more quickly and accurately. It also has the ability to adapt its responses over time, making it a powerful tool for combating ever-evolving cyber threats. Many companies now deploy AI security software as part of their comprehensive cybersecurity strategy. Compare and read user reviews of the best AI Security software for Microsoft 365 currently available using the table below. This list is updated regularly.
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1
Adaptive Security
Adaptive Security
Adaptive Security is OpenAI’s investment for AI cyber threats. Founded in 2024, Adaptive raised $50M+ from investors like OpenAI and a16z, as well as executives at Google Cloud, Fidelity, Shopify, and more. Adaptive protects customers from deepfakes, vishing, smishing, and AI email phishing with its next-generation security awareness training and phishing simulations. Security teams prepare employees for advanced threats with highly customized training that is role-based, enriched with OSINT, and even features deepfakes of their own executives. Employees train on mobile or desktop and rate the content an incredible 4.9/5 on average. Customers measure the success of their training program with AI-powered phishing tests. Realistic deepfake, voice, SMS, and email tests track risk across every vector. Trusted by Figma, the Dallas Mavericks, BMC, and others, Adaptive boasts a world-class NPS of 94. Want to learn more? Take a self-guided tour at adaptivesecurity.com. -
2
IBM QRadar SIEM
IBM
Market-leading SIEM built to outpace the adversary with speed, scale and accuracy As digital threats loom large and cyber adversaries grow increasingly sophisticated, the roles of SOC analysts are more critical than ever. Going beyond threat detection and response, QRadar SIEM enables security teams face today’s threats proactively with advanced AI, powerful threat intelligence, and access to cutting-edge content to maximize analyst potential. Whether you need cloud-native architecture built for hybrid scale and speed or a solution to complement your on-premises infrastructure, IBM can provide you with a SIEM to meet your needs. Experience the power of IBM enterprise-grade AI designed to amplify the efficiency and expertise of every security team. With QRadar SIEM, analysts can reduce repetitive manual tasks like case creation and risk prioritization to focus on critical investigation and remediation efforts. -
3
Varonis Data Security Platform
Varonis
The most powerful way to find, monitor, and protect sensitive data at scale. Rapidly reduce risk, detect abnormal behavior, and prove compliance with the all-in-one data security platform that won’t slow you down. A platform, a team, and a plan that give you every possible advantage. Classification, access governance and behavioral analytics combine to lock down data, stop threats, and take the pain out of compliance. We bring you a proven methodology to monitor, protect, and manage your data informed by thousands of successful rollouts. Hundreds of elite security pros build advanced threat models, update policies, and assist with incidents, freeing you to focus on other priorities. -
4
SydeLabs
SydeLabs
With SydeLabs you can preempt vulnerabilities and get real-time protection against attacks and abuse while staying compliant. The lack of a defined approach to identify and address vulnerabilities within AI systems impacts the secure deployment of models. The absence of real-time protection measures leaves AI deployments susceptible to the dynamic landscape of emerging threats. An evolving regulatory landscape around AI usage leaves room for non-compliance and poses a risk to business continuity. Block every attack, prevent abuse, and stay compliant. At SydeLabs we have a comprehensive solution suite for all your needs around AI security and risk management. Obtain a comprehensive understanding of vulnerabilities in your AI systems through ongoing automated red teaming and ad-hoc assessments. Utilize real-time threat scores to proactively prevent attacks and abuses spanning multiple categories, establishing a robust defense against your AI systems.Starting Price: $1,099 per month -
5
Dropzone AI
Dropzone AI
Dropzone AI replicates the techniques of elite analysts and autonomously investigates every alert. Our specialized AI agent autonomously performs end-to-end investigations and will cover 100% of your alerts. Trained to replicate the investigation techniques of best-in-class SOC analysts, its reports are fast, detailed and accurate. You can also go deeper with its chatbot. Dropzone’s cybersecurity reasoning system, purpose-built on top of advanced LLMs, runs a full end-to-end investigation tailored for each alert. Its security pre-training, organizational context understanding and guardrails make it highly accurate. Dropzone then generates a full report, with the conclusion, executive summary, and full insights in plain English. You can also converse with its chatbot for ad-hoc inquiries.Starting Price: $36,000/year -
6
Plurilock AI Cloud DLP
Plurilock Security
Plurilock AI Cloud DLP is a cloud-native yet endpoint-capable data loss prevention (DLP) solution that also provides passwordless SSO and CASB. It is designed specifically for cloud-centric companies relying on an army of SaaS applications to succeed. With Plurilock AI Cloud DLP, companies without the resources to configure and manage (much less pay for) the "default" incumbent DLP solutions can still gain the benefits of full-featured DLP, but at a level of simplicity and cost-effectiveness that makes DLP accessible to companies that don't specialize in IT. Plurilock AI Cloud DLP is part of the Plurilock AI platform, which grows as companies do, with an expansion path to true continuous, real-time authentication and user/entity behavior analytics (UEBA) for real-time biometric identity threat detection and response (ITDR). Plurilock AI is rated top in the industry in customer satisfaction by Info-Tech, based on the feedback of actual customers.Starting Price: $36/user/year -
7
Darktrace
Darktrace
Darktrace is a cybersecurity platform powered by AI, providing a proactive approach to cyber resilience. Its ActiveAI Security Platform delivers real-time threat detection, autonomous responses to both known and novel threats, and comprehensive visibility into an organization’s security posture. By ingesting enterprise data from native and third-party sources, Darktrace correlates security incidents across business operations and detects previously unseen threats. This complete visibility and automation reduce containment time, eliminate alert fatigue, and significantly enhance the efficiency of security operations. -
8
Abnormal AI
Abnormal AI
Abnormal AI offers a behavioral AI platform designed to protect humans from sophisticated email threats like phishing, social engineering, and account takeovers. The platform leverages advanced anomaly detection to identify and stop AI-powered email attacks that operate at machine speed and evade traditional defenses. It delivers fully autonomous threat detection and response with minimal manual intervention. Abnormal AI integrates seamlessly with cloud email platforms, enhancing security without adding operational overhead. Trusted by over 3,000 customers including many Fortune 500 companies, it has demonstrated significant reductions in phishing attacks and SOC workload. Its unique human-focused, behavior-driven approach helps organizations proactively defend against evolving cyber threats. -
9
Vectra AI
Vectra
Vectra enables enterprises to immediately detect and respond to cyberattacks across cloud, data center, IT and IoT networks. As the leader in network detection and response (NDR), Vectra uses AI to empower the enterprise SOC to automate threat discovery, prioritization, hunting and response. Vectra is Security that thinks. We have developed an AI-driven cybersecurity platform that detects attacker behaviors to protect your hosts and users from being compromised, regardless of location. Unlike other solutions, Vectra Cognito provides high fidelity alerts instead of more noise, and does not decrypt your data so you can be secure and maintain privacy. Today’s cyberattacks will use any means of entry, so we provide a single platform to cover cloud, data center, enterprise networks, and IoT devices, not just critical assets. The Vectra NDR platform is the ultimate AI-powered cyberattack detection and threat-hunting platform. -
10
Zenity
Zenity
Enterprise copilots and low-code/no-code development platforms make it easier and faster than ever to create powerful business AI applications and bots. Generative AI makes it easier and faster for users of all technical backgrounds to spur innovation, automate mundane processes, and craft efficient business processes. Similar to the public cloud, AI and low-code platforms secure the underlying infrastructure, but not the resources or data built on top. As thousands of apps, automation, and copilots are built, prompt injection, RAG poisoning, and data leakage risks dramatically increase. Unlike traditional application development, copilots and low-code do not incorporate dedicated time for testing, analyzing, and measuring security. Unlock professional and citizen developers to safely create the things they need while meeting security and compliance standards. We’d love to chat with you about how your team can unleash copilots and low-code development. -
11
Skypher
Skypher, Inc.
Easily communicate your security posture with clients and prospects. Save time and win more deals with Skypher’s AI security questionnaire automation software. Save hours with Skypher’s AI Questionnaire Automation Tool, enabling you to complete complex questionnaires autonomously with a single click. Manage and access all your security data in one platform (knowledge base, documents, previous projects and any custom online wiki or external data sources). Reduce time to get your POCs and contracts running and build trusted relationship with your clients regarding cybersecurity. Leverage the power of AI through an intuitive, collaborative platform with granular access controls to return questionnaires in less than 2 hours.
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