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WM Hyperintensities Segmentation Toolbox

Open Source White Matter Hyperintensities Segmentation Toolbox

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Wisconsin White Matter Hyperintensity Segmentation [W2MHS] and Quantification Toolbox is an open source MatLab toolbox designed for detecting and quantifying White Matter Hyperintensities (WMH) in Alzheimer’s and aging related neurological disorders. WMHs arise as bright regions on T2- weighted FLAIR images. They reflect comorbid neural injury or cerebral vascular disease burden. Their precise detection is of interest in Alzheimer’s disease (AD) with regard to its prognosis. Our toolbox provides a self-sufficient set of tools for segmenting these WMHs reliably and further quantifying their burden for down-processing studies.

WM Hyperintensities Segmentation Toolbox Web Site


  • Detects white matter hyperintensities in T2-FLAIR images
  • Segments hyperintsnsities and quantifies burden for down-processing studies
  • Comes with an SPM12 based preprocessign module
  • Simple GUI with batch processing capability
  • Open Source MATLAB toolbox
  • Customizable parameters


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Additional Project Details

Intended Audience

Healthcare Industry, Science/Research

User Interface

Win32 (MS Windows)

Programming Language




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