VacSol

Infectious diseases are emerging rapidly throughout the globe, and antibiotic resistant bacterial strains lead to the therapeutic failure; ultimately causing the high risk of cost and re-infection. Vaccination is considered as one of the most effective mechanisms for the treatment of a particular disease; and conventional vaccinology approaches have rendered certain limitations against some pathogens. Reverse vaccinology and subtractive proteomics are novel competent computational approaches to identify putative therapeutic targets against the infectious agents. In current study we have developed an in silico, multi-threaded, configurable and scalable pipeline employing subtractive-reverse vaccinology analysis technique and named it VacSol (https://sourceforge.net/projects/vacsol/). The principle objective of the VacSol development is to screen out genes/proteins from microbial genome/proteome that could be employed as potential therapeutic targets