TAMeBS-0.4 is designed for mapping BS reads on to a reference genome and providing simple analysis of methylation status of each cytosine in genome. It has perfect capability to detect many more uniquely mapped reads that other existing tools while achieving an excellent balance between sensitivity and precision. The recent version works best for single-end BS reads generated from directional protocal. Moreover, insertion and deletion are not taken into account in the alignemnt process.
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