DownloadSPINA is software for determining constant structure parameters of endocrine feedback control systems from hormone levels obtained in vivo.
The first version of this cybernetic approach allows for evaluating the functional status of the thyroid gland, i.e. thyroid's secretory capacity (GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD).
A second version has been developed for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor gain (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI).
Both implementations of SPINA have been validated in clinical studies on the basis of large cohorts.
Features
- More than 25 years of continued development
- Based on published parametrically isomorphic model of thyroid and insulin-glucose homeostasis
- Algorithm evaluated in multiple clinical trials with thousands of patients
- Suport for different units of measurement
- Data import and export in HL7 format
- Curated by SciScrunch, OpenAIRE and Zenodo
- Cross-platform for Mac OS Classic, macOS (Mac OS X), Windows, Linux and Palm OS / Garnet OS
- DOI 10.5281/zenodo.3596049 https://doi.org/10.5281/zenodo.3596049
Project Samples
License
BSD License
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User Reviews
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Can't download it in Mac - says it needs to be updated and can't check it for malicious software. I'm really looking forward to trying this out in the future and hope it can be fixed.Reply from SPINAEdited 2024-02-24
This is a known issue that results from the fact that Apple changed the process of code signing. The next version of SPINA Thyr will be easily usable on all current versions of macOS again. BTW, you can start any app by right-clicking (or control-clicking) and selecting “Open” in the context menu. This procedure may, however, in some cases involve a security risk, since it bypasses the GateKeeper mechanism. Sorry again for the inconvenience. The issue has been resolved in SPINA Thyr 4.2.1. Please download and enjoy the new version. -
Unable to run on MACReply from SPINAEdited 2024-02-24
This is a known issue that results from the fact that Apple changed the process of code signing. The next version of SPINA Thyr will be easily usable on all current versions of macOS again. BTW, you can start any app by right-clicking (or control-clicking) and selecting “Open” in the context menu. This procedure may, however, in some cases involve a security risk, since it bypasses the GateKeeper mechanism. Sorry again for the inconvenience. The issue has been resolved in SPINA Thyr 4.2.1. Please download and enjoy the new version. -
I downloaded it but MacOS says it cannot be checked for malicious spyware and so it will not open. I hope this can be fixed as I was really looking forward to trying this program!Reply from SPINAEdited 2024-02-24
This is a known issue that results from the fact that Apple changed the process of code signing. The next version of SPINA Thyr will be easily usable on all current versions of macOS again. BTW, you can start any app by right-clicking (or control-clicking) and selecting “Open” in the context menu. This procedure may, however, in some cases involve a security risk, since it bypasses the GateKeeper mechanism. Sorry again for the inconvenience. The issue has been resolved in SPINA Thyr 4.2.1. Please download and enjoy the new version.