SimPET Files

This folder includes the simulated subjects we used for our study "Added Value of Quantitative [18F]FDG-PET Analysis in Non-Lesional Epilepsy: A simulation-based study using realistic ground-truths". A total of 125 subjects were simulated in this study, distributed as:

	- 25 Controls (healthy, no hypometabolism)
	- 100 Subjects (pathologic, with hypometabolism)
		- 75 Subjects with focal hypometabolism
		- 25 Subjects with extended hypometabolism

 In each subject folder, the following images (in NifTI format) are included:

	- PET Simulation
	- Quantification
	- Activity Map
	- Attenuation Map

Please note that the activity and attenuation maps are inverted respect to the simulation and quantification. To retrieve the simulations, the SimPET simulator was used. It is openly available at the Github repository https://github.com/txusser/simpet. To obtain the PET simulations from the maps directly, please download and follow the instructions on the previous repository. The quantifications were obtained on each simulation using the platform Neurocloud (https://www.neurocloud.es/en).

In the excel sheet data.xlsx you will find the following information:

	- Subject: ID of the subject.
	- Status: Whether it is a Control or a Subject.
	- Original Control: Refers to which of the controls' original map was used as a base to define the hypometabolic region (Each control corresponds to one healthy patient, three focal hypometabolism subjects and one extended hypometabolism subject).
	- Age (in years)
	- Hypometabolism level: For the pathologic cases, indicates the level of hypometabolism to define the lesion.
	- Lesion type: Whether it is a Focal or an Extended hypometabolism.
	- Hypometabolism Region: Brain region where the hypometabolism was placed in the activity map. These refer to regions defined on the Hammersmith Atlas.
	- Laterality: Whether the lesion is at the left (L) or right (R) hemisphere.

If you use any of this material for your study, please do not forget to cite our article! :) For any other doubts or concerns, or in order to request additional data from our study, please do not hesitate to contact the corresponding authors: Aida Niñerola-Baizán (ninerola@clinic.cat) and Pablo Aguiar (pablo.aguiar@usc.es).