R scripts for multivariate analysis Files

Database macormolecule dissolution from PLGA microspheres.

Overall are 745 data records and 300 variables.
The independent parameters contained 300 inputs covering the formulation characteristics (PLGA inherent viscosity, PLGA molecular weight, lactide-to-glycolide ratio, inner and outer phase Polyvinyl alcohol (PVA) concentration, PVA molecular weight, inner phase volume, encapsulation rate, mean particle size, and PLGA concentration); the experimental conditions (dissolution pH, number of dissolution additives, dissolution additive concentration and production method, and dissolution time); and the molecular descriptors of the macromolecules and excipients.
The molecular descriptors were computed using Marvin cxcalc plugin, UK (version 5.11; ChemAxon, Budapest, Hungary) for the drug substance as well as the excipients.
The amount (%) of the drug substance released (Q) was the only dependent variable. 

File "Supplementary_material_S2.xlsx" contains the whole database with labels.
File "300in_PLGA_database.tar.gz" contains the divison of the database for 10-cv folds and separate dissolution profiles.

The database is an extension of original database published in Dove Press journal:
Szlęk J, Pacławski A, Lau R, Jachowicz R, Mendyk A. "Heuristic modeling of macromolecule release from PLGA microspheres". International Journal of Nanomedicine, Volume 2013:8(1) Pages 4601—4611. DOI https://dx.doi.org/10.2147/IJN.S53364, (https://www.dovepress.com/heuristic-modeling-of-macromolecule-release-from-plga-microspheres-peer-reviewed-article-IJN)
The orginal database was published under Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0) license (https://creativecommons.org/licenses/by-nc/3.0/)