Just run the install program. It will automatically install the template and the key maker. It makes a shortcut to the key maker on the start menu and desktop. In order to use this, just click create new program in the start page or however you personally do it in vb.net 2008. Then choose the NReg System Template. Right click the Registration System.vb and choose view code. At the top are all the variables you need to change. They just include your email, mals id, ban list website, used key list website, plus, program id, amount of trial uses, and the seconds until the continue button works.
Source: README (INCLUDED IN THE INSTALL DOWNLOAD).txt, updated 2009-09-02