NanoGLADIATOR

Nano-GLADIATOR is a novel software tool that allows to analyze WGS data generated during a MinION or GridION X5 run for the detection of copy number alterations (CNAs).
Nano-GLADIATOR (Nanopore Genomic aLterations AnD allelIc frAcTiOn pRedictor) is capable to perform CNVs/CNAs detection and allelic fraction prediction during the sequencing run ("On-line" mode for real time molecular karyotyping) and once the experiment is completed ("Off-line" mode, for parallel analysis of multiple samples).
In "On-line" mode the tool must be launched simultaneously to a nanopore experiment so that, by exploiting the data flow generated during the sequencing process, it can perform real-time CNVs/CNAs detection. In "Off-line" mode Nano-GLADIATOR can be used to perform parallelized analysis of multiple runs at once for the identification of germline CNVs and somatic CNAs.