MutationMapper

MutationMapper is built to help simplify determining the functional consequences of mutations discovered using low-throughput sequencing methods (e.g. Sanger sequencing) and to map CDS coordinates to genomic positions. For details of how to use MutationMapper see the instructions PDF available using the 'help' option in the application or available here.

MutationMapper v2.0 uses Ensembl’s REST API to search genes, sequences and determine functional consequences of mutations. It therefore only works when an internet connection is available.

This is the first release of MutationMapper since it's rewrite as a multiplatform (Mac OS X, Linux and Windows) application.

All versions only work with 64-bit systems.

Using short sequences of wild type vs mutant DNA, MutationMapper will report the functional consequence of a given mutation. It can also be used for mapping sequences or CDS coordinates to genomic positions. For more information see the help documentation.

INSTALL

64 bit systems only

Linux: Download the MutationMapper-Linux64-2.0-1.x86_64.rpm (for RPM-based distros - e.g. CentOS), MutationMapper-Linux64-2.0.deb (for DEB based distros, e.g. Ubuntu) or MutationMapper-Linux64-2.0-1.pkg.tar.xz (Arch Linux) depending on your system and install via your package manager (e.g. sudo dpkg -i MutationMapper-Linux64-2.0.deb) or, if your distribution supports it, by double-clicking the downloaded package.

Mac OS X: Download the MutationMapper-MacOSX-2.0.dmg disk image. Double click to open the downloaded file and drag the MutationMapper application into your Applications folder where it can be opened by double clicking. On recent versions of Mac OS X you will need to access the 'Security & Privacy' settings in System Preferences to allow this app to be opened.

Windows: Download the MutationMapper-2.0-windows-installer.exe installer application. Double click the downloaded file and follow the instructions to install. This will also launch MutationMapper once installed. To launch in future it should be accessible from the Start menu->All Programs->MutationMapper. MutationMapper will be installed to C:\Users[Your Username]\AppData\Local\MutationMapper\MutationMapper.exe.

UNINSTALL

Linux: Uninstall via your package manager (e.g. sudo apt-get remove MutationMapper).

Mac OS X: Drag the MutationMapperapplication from your Applications folder to the recycle bin.

Windows 7: MutationMapper should be installed to 'C:\Users[Your Username]\AppData\Local\MutationMapper\MutationMapper.exe'. To uninstall double-click the 'unins000.exe' file in this location. You can also access this location by right-clicking the MutationMapper application from the Start menu, selecting 'Properties' and clicking the 'Open File Location' button in the resulting window.