IBEIP

We developed IBEIP, an intelligent and accurate tool for identifying B cell dominant epitope regions based on Ag-nAb complex crystal structures from PDB database. During epitope mapping, IBEIP analyzes four molecular interactions (van der Waals forces, buried surface area, hydrogen bonds, and electrostatic interactions) between antigen and antibody complexes to ensure accuracy. IBEIP uses a hierarchical iterative merging model to merge highly overlapping epitopes and identify the hot nAb binding region as the B cell dominant epitope region. IBEIP is also applicable to analyzing high-mutant antigens and complex epitope structures that span adjacent monomers.
Citation: Yun-Fei Ma, Ye Liu. Intelligent Batch Epitope Identification and Partitioning: an intelligent tool for the identification of B cell dominant epitopes. Brief. Bioinform. 2025, 26(4):bbaf310.