Frame-Pro

Frame-Pro is a profile homology search tool for PacBio reads. Frame-Pro corrects sequencing errors and also output the profile alignments of the corrected sequences against characterized protein families. The results of Frame-Pro showed that our method enables more sensitive homology search and corrects more errors compared to a popular error correction tool that does not rely on hybrid sequencing.

The directories is introduced below:

SampleCode

• This is the code used for the experiment in the paper, however we skip the output of the HMM alignment in the code.

SampleCode_Single

• This is the original test code. The output has the HMM alignment. However, the code is for single seed sequence and alignment input.

Data

• This folder contains domain data about the Human arm metegenomics experiment

Citation

Du, N. & Sun, Y.N. (2016). Improve homology search sensitivity of PacBio data by correcting frameshifts. Acceptted by ECCB 2016.

For questions, please contact:

Nan Du

Michigan State University, East Lansing, MI 48910

dunan [at] msu [dot] edu