Regulatory agencies increasingly apply benchmark dose (BMD) modeling to determine points of departure for risk assessment. BMDExpress applies BMD modeling to transcriptomic datasets to identify transcriptional BMDs. However, graphing and analytical capabilities within BMDExpress are limited, and the analysis of output files is challenging.

We developed a web-based application, BMDExpress Data Viewer for visualizing and graphing BMDExpress output files. BMDExpress Data Viewer is a useful tool to visualize, explore and analyze BMDExpress output files. Visualizing the data in this manner enables rapid assessment of data quality, model fit, doses of peak activity, most sensitive pathway perturbations and other metrics that will be useful in applying toxicogenomics in risk assessment.

Tool Link: http://apps.sciome.com:8082/BMDX_Viewer/

Publication Link: http://onlinelibrary.wiley.com/doi/10.1002/jat.3265/abstract

Project Samples

Home Screen BMD Analysis Summary Functional Classifications Dynamic Viewer Functional Enrichment Analysis Multiple Dataset Comparison BMDL-BMD Range Plotter

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Data Quality

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Registered

2015-12-14
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