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BigBang/Horizon is a proteomics data analysis pipeline with focus on the shotgun LC/MSMS workflow.

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  • State-of-the-art proteomics data analysis (LC/MSMS)
  • Graphical user interface (easy to use)
  • Independent data processing modules (windows services)
  • Independently archivable projects
  • All data is kept in database, no need to look for your files in various places
  • Experiment design support: organize samples into biological samples and repeats
  • .RAW file import
  • Data preprocessing prior to database search
  • Batch mascot submission
  • Combination of search results for downstream analysis
  • Peptide-level FDR analysis with flexible mixture model (Choi et al, 2008)
  • Protein identification
  • Protein posterior probability calculation using Bayesian methods (Serang et al, 2010)
  • TMT/iTRAQ quantitation (isotope error correction with a non-negative least squares method)
  • Exports to text file (csv, tsv) and Excel
  • Queuing system for data processing tasks


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Additional Project Details



Intended Audience

Developers, Information Technology, Science/Research

User Interface

.NET/Mono, Win32 (MS Windows)

Programming Language

ASP.NET, C#, C++, S/R



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