Hyperdeiodination compensates for beginning thyroid failure

Recent research based on SPINA and numeric simulations with SimThyr had suggested the existence of a functional TSH-T3 shunt in humans. This hypothesis was now re-evaluated in a study with 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease. The study, which has been published in the European Thyroid Journal, found a significant and nonlinear negative association between SPINA-GD and SPINA-GT, even after correction for spurious correlation. The results of this study demonstrate that the euthyroid panel doesn't follow a homogeneous pattern to produce randomly-distributed TSH concentrations and thyroid hormones, but that it forms a heterogeneous group displaying distinctly different levels of homeostatic equilibria across the euthyroid range. It also confirms earlier assumptions that the TSH-T3 shunt mediates a compensatory response, where a sinking thyroid's secretory capacity is partly offset by increasing deiodination, thus maintaining FT3 concentrations in a normal range despite beginning hypothyroidism.

This "online first" paper is available from http://dx.doi.org/10.1159/000447967 .

Reference:
Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease
Hoermann R., Midgley J.E.M., Larisch R., Dietrich J.W.
Eur Thyroid J, in Press
doi: 10.1159/000447967

Posted by Dr. Johannes W. Dietrich, M.D. 2016-08-24 Labels: SPINA SPINA-GT SPINA-GD TSH-T3 shunt hypothyroidism euthyroidism

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