#382 edit definition for "insulator"

None
pending
nobody
None
5
2013-07-30
2013-03-21
mlaw
No

proposed definition:
A transcriptional cis regulatory region (ranges from 0.5kb to 3kbp) that when located between an enhancer and a promoter, the insulator prevents the enhancer from modulating expression of that gene.

Discussion

  • Karen Eilbeck

    Karen Eilbeck - 2013-05-17

    DO you have a reference for this?

     
  • Karen Eilbeck

    Karen Eilbeck - 2013-07-30
    • status: open --> pending
    • Group: -->
     
  • Karen Eilbeck

    Karen Eilbeck - 2013-07-30

    I think this may need to also include chromatin.

    Insulators prevent interactions between promoters and enhancers in a position-dependent manner due to their ability to influence higher order chromatin structure

    I'm setting this to pending and will talk to you when you get back in town.

     

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