There are a few issues concerning missense mutations:
1. SO:0001583 : non-synonymous_codon should have as part of its definition 'non-sense mutation' (or stop gained), since that's a child.
2. It should be possible to annotate a missense mutation without specifying whether the mutation is conservative or non-conservative (since that concept is not defined in the ontology and there are different ways of defining this).
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