SimulaBeta / Blog: Recent posts

Early diagnosis of diabetes mellitus continues to be a challenge. Established test protocols are either elaborate and expensive or of limited quality, and even the concept of prediabetes is debated. The key determinants of glucose homeostasis, beta cell function and insulin sensitivity, have low utility when assessed independently. Their combination, the dynamic disposition index, a measure of the feedback loop’s circular gain, is a more meaningful parameter for the homeostatic function. Still, its determination requires a frequently sampled oral glucose tolerance test, a complex and time-consuming procedure.... read more

SimulaBeta has been updated to version 3.1.2. This release fixes several bugs. It is the first version to be based on CyberUnits Bricks 2.0.

Today, SimulaBeta has been updated to version 3.1.1. This is a bug-fix release that is recommended to all users. It addresses a memory leak in the application and an issue in the GUI of LOREMOS.

SimulaBeta gains function after function and gets more and more complex. Therefore we began to write a handbook.

A first version is available from http://dx.doi.org/10.6084/m9.figshare.22578274 or from https://sourceforge.net/projects/simulabeta/files/Documentation/.

Today, SimulaBeta has been released in version 3.1.0. This is a major upgrade that introduces a plethora of new features including a load, reference and modulation sequencer (LOREMOS) to simulate complex patterns of external influences on glucose homeostasis, sensitivity analysis in form of a disposition table and support for different units of measurement for insulin and glucose concentrations.

SimulaBeta has been updated to version 3.0.2. This bug-fix release is intended for all platforms.

SimulaBeta has been released in version 3.0.1. This release fixes some minor bugs. Additionally it is the first version that supports the Apple Silicon processor architecture on newer Macs.

Version 3.0 (Tournado) of SimulaBeta has been released. This major upgrade features multiple new functions and bug fixes. See the version history for more details.

SPINA Carb, a novel method for calculating beta cell function (SPINA-GBeta) and insulin sensitivity (SPINA-GR) has been developed with support by SimulaBeta.

The method and the theory, which it is based on, are described in the journal Scientific Reports. See https://rdcu.be/cX0Y3, https://www.nature.com/articles/s41598-022-22531-3 or https://doi.org/10.1038/s41598-022-22531-3 .

Today, the next major version of SimulaBeta has been released. SimulaBeta 2.2.0 (Malakow) introduces the possibility to simulate an oral glucose tolerance test (oGTT). Additionally, several bugs have been fixed.

SimulaBeta 2.1.1 is available. This is a bug fix release that is recommended for all platforms.

SimulaBeta 2.1 has been released. This version introduces ivGTT (fsIGT) simulation, several improvements of the GUI and multiple bug fixes.

SimulaBeta has been curated by the trusted registries Zenodo and SciCrunch. See https://doi.org/10.5281/zenodo.4922800 and http://scicrunch.org/browse/resources/SCR_021900 for details.

SimulaBeta is available in version 2.0. This is the first publicly available version. Binaries are compatible with macOS and Windows. Sourcecode, e.g. for building the app for BSD or Linux, is provided as well.