Publications on SimThyr or its theory by members of the SimThyr team:
  1. Dietrich JW, Mitzdorf U, Weitkunat R, Pickardt CR. The pituitary-thyroid feedback control: stability and oscillations in a new nonlinear model. Journal of Endocrinological Investigation. 1997;20(Suppl. to no. 5):100.

  2. Dietrich JW, Fischer MR, Jauch J, Pantke E, Gärtner R, Pickardt CR. SPINA-THYR: A novel systems theoretic approach to determine the secretion capacity of the thyroid gland. European Journal of Internal Medicine. 1999;10 (Suppl. 1)(May 1999):S34.

  3. Dietrich JW. Signal Storage in Metabolic Pathways: The ASIA Element. kybernetiknet. 2000;1(3, 2000):1-9.

  4. Dietrich JW, Tesche A, Pickardt CR, Mitzdorf U. Fractal Properties of the Thyrotropic Feedback Control: Implications of a Nonlinear Model Compared with Empirical Data. In: Trappl R, ed. Cybernetics and Systems 2002. Vienna: Austrian Society for Cybernetic Studies; 2002:329-34.

  5. Dietrich JW. Der Hypophysen-Schilddrüsen-Regelkreis. Entwicklung und klinische Anwendung eines nichtlinearen Modells. Vol. 2 Berlin: Logos-Verlag; 2002. (Schardt F, ed. Spektrum medizinischer Forschung).

  6. Dietrich JW, Tesche A, Pickardt CR, Mitzdorf U. Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis. Cybernetics and Systems. 2004;35(4):315-31. doi: 10.1080/01969720490443354.

  7. Dietrich, J. W. and B. O. Boehm (2006). Equilibrium behaviour of feedback-coupled physiological saturation kinetics. In: Cybernetics and Systems 2006. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies. 1: 269-74.

  8. Dietrich, J. W., A. Stachon, B. Antic, H. H. Klein und S. Hering (2008). The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome. BMC Endocrine Disorders 8 (13). PMID 18851740, doi 10.1186/1472-6823-8-13.

  9. Dietrich, J. W., G. Landgrafe, E. H. Fotiadou (2012). TSH and thyrotropic agonists: Key actors in thyroid homeostasis. Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. PMID 23365787, doi:10.1155/2012/351864.

  10. Hoermann, R., J. E. M. Midgley, R. Larisch, J. W. Dietrich (2013). Is Pituitary Thyrotropin an Adequate Measure Of Thyroid Hormone-Controlled Homeostasis During Thyroxine Treatment?. European Journal of Endocrinology 168(2):271-80. PMID 23184912, doi: 10.1530/EJE-12-0819.

  11. Midgley, J. E. M., R. Hoermann, R. Larisch, J. W. Dietrich (2013). Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model. Journal of Clinical Pathology 66(4):335-42. PMID 23423518, doi: 10.1136/jclinpath-2012-201213.

  12. Hoermann R, Midgley JE, Larisch R, Dietrich JW (2015). Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Hormone and Metabolic Research, PMID: 25750078 doi: 10.1055/s-0034-1398616.

  13. Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH., Midgley JE, Hoermann R. Calculated parameters of thyroid homeostasis: Emerging tools for differential diagnosis and clinical research. Frontiers in Endocrinology. 2016; 7:00057. PMID:27375554 doi: 10.3389/fendo.2016.00057.

Known third party publications covering SimThyr:
  1. Lupínek, J. (2012). Freeware simulační a vizualizační nástroje pro GNU/Linux. Západočeská univerzita v Plzni. Fakulta elektrotechnická, Katedra elektromechaniky a výkonové elektroniky. PDF version.

  2. Han, S. X. H. (2013). THYROSIM: A Web Application for Human Thyroid System Regulation Education and Research. UNIVERSITY OF CALIFORNIA, LOS ANGELES. PDF version at, ProQuest entry.

These publications cover different models for special applications that however partially utilize the MiMe-NoCoDI model SimThyr is based on.

  1. Goede SL, Leow MK, Smit JW, Dietrich JW. A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications. Math Biosci. 2014 Mar;249:1-7. doi: 10.1016/j.mbs.2014.01.001. Epub 2014 Jan 28. PMID 24480737.

  2. Goede SL, Leow MK, Smit JW, Klein HH, Dietrich JW. Hypothalamus-Pituitary-Thyroid Feedback Control: Implications of Mathematical Modeling and Consequences for Thyrotropin (TSH) and Free Thyroxine (FT4) Reference Ranges. Bull Math Biol. 2014 May 1. PMID 24789568.


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