#417 GSE216264, GSE216263 PMID: 39196177

[wdemos]

XCO: thoracic aortic constriction sham procedure

Rats were either subjected to aortic banding or sham aortic binding. pulmonary artery occlusion or pulmonary artery occlusion sham procedure. Best fit for aortic banding is thoracic aortic constriction so please create the sham child term.

Ascending AOB and PAB were performed in 7-week-old weanling
Wistar × Lewis hybrid rats using non-constricting titanium clips (Weck
Horizon, Teleflex Medical GmbH) with inner diameters of 0.6 mm
(AOB) or 1.1 mm (PAB). Clip sizes were based on previous investigations for AOB54 or on preceding tests (for PAB) and resulted in similar
hypertrophy rates by AOB or PAB in male and female rats. Anterolateral thoracotomy under isoflurane anaesthesia in fully ventilated rats
was performed as published, with sham-operated animals serving as
age-matched controls55. In growing-up animals, increasing vasoconstriction resulted in compensatory LV (AOB model) or RV hypertrophy
(PAB model) 7 weeks after surgery, followed by the onset of LV (AOB
model) or RV (PAB model) failure 22–26 weeks later.

[Stan Laulederkind]

thoracic aorta constriction sham procedure (XCO:0001462)