See http://www.mail-archive.com/pyxb-users@lists.sourceforge.net/msg00194.html
Fixed in following commit available in next branch of git repository.
commit 6bfba111495de9554bec0a91262ffeef595cb938 Author: Peter A. Bigot <pab@pabigot.com> Date: Wed Oct 9 14:16:03 2013 -0500 trac/219: append with mixed content creates unbound ElementContent This occured only with wildcards, and was due to too lax filtering of unrecognized values. Only material that has enough information identify an element may be added as a wildcard. Other material may be accepted as mixed content, if the type permits this.
Fixed in following commit available in next branch of git repository.