I just downloaded and installed 0.11.1 for my Mac. The app throws an exception straightaway, saying it cannot find:

File "/Users/Brett/Source/PyX-0.11.1/pyx/filelocator.py", line 274, in open
    raise IOError("Could not locate the file '%s'." % filename)
IOError: Could not locate the file 'psfonts.map|psfonts_t1.map|psfonts_pk.map'.

If I put spaces, rather than | in my .pyxrc it works fine. 

I suspect this may be an old .pyxrc file, is that the problem?