Using Windows XP SP3 + wxPython 2.8.9.x + Python 2.5(or 2.6), if you select an existing component in the resource or layout editor tools it shifts. Not all components are affected:
code editor
tree
list
multicolumn list
calendar
spinner
gauge
HTML control
The spinner shifts left 1 pixel, the gauge left and up, the rest down and right 2 pixels.
There is another report on the user list of the same components shifting a lot more in Ubuntu. I have tested in OpenBSD but no components seem to shift in that.