#90 For ImmPort Antibody Registry (first batch)

[Alexander Diehl]

Protein Ontology SourceForge Requests from Alexander Diehl and Travis Allen for ImmPort Anitbody Registry project:

H2A.X (Ser139)
http://www.phosphosite.org/proteinAction.do?id=2540&showAllSites=true

id: PR:newterm1
name: histone H2A.x phosphorylated 1
definition: A histone H2A.x that has been post-translationally modified to include a phosphoserine at position 140 of the full-length sequence (position 139 of the mature sequence). [PMID:11993987]
exact synonym: H2A.X (Ser139)
related synonym: gamma-H2A.X
is_a: PR:000008418 ! histone H2A.x

id: PR:newterm2
name: histone H2A.x phosphorylated 1 (human)
definition: A histone H2A.x phosphorylated 1 in human. [PMID:11993987]
exact synonym: H2A.X (Ser139) (human)
related synonym: gamma-H2A.X (human)
is_a: PR:newterm1 ! histone H2A.x phosphorylated 1
is_a: PR:P16104 ! histone H2A.x (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm1 ! histone H2A.x phosphorylated 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

Btk (pY551)
http://www.phosphosite.org/proteinAction.do?id=450&showAllSites=true

id: PR:newterm3
name: tyrosine-protein kinase BTK phosphorylated 1
definition: A tyrosine-protein kinase BTK that has been post-translationally modified to include a phosphotyrosine at position 551 of the full-length sequence in human or mouse or a homologous position in other species. [PMID:7565679]
exact synonym: ATK (pY551)
exact synonym: B-cell progenitor kinase (pY551)
exact synonym: BPK (pY551)
exact synonym: BTK (pY551)
exact synonym: agammaglobulinaemia tyrosine kinase (pY551)
exact synonym: bruton tyrosine kinase (pY551)
exact synonym: kinase EMB (pY551)
is_a: PR:000002110 ! tyrosine-protein kinase BTK

id: PR:newterm4
name: tyrosine-protein kinase BTK phosphorylated 1 (human)
definition: A tyrosine-protein kinase BTK phosphorylated 1 in humans. [PMID:7565679]
exact synonym: hBTK (pY551)
is_a: PR:newterm3 ! tyrosine-protein kinase BTK phosphorylated 1
is_a: PR:Q06187 ! tyrosine-protein kinase BTK (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm3 ! tyrosine-protein kinase BTK phosphorylated 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

Itk (pY511)
http://www.phosphosite.org/proteinAction.do?id=10528&showAllSites=true

id: PR:newterm5
name: tyrosine-protein kinase ITK/TSK
definition: A tyrosine-protein kinase ITK/TSK that has been post-translationally modified to include a phosphotyrosine at position 512 (position 511 mature form) of the full-length sequence in human, or a homologous position in other species. [PMID:9312162]
exact synonym: IL-2-inducible T-cell kinase (pY511)
exact synonym: ITK (pY511)
exact synonym: T-cell-specific kinase (pY511)
exact synonym: kinase EMT (pY511)
exact synonym: kinase TLK (pY511)
exact synonym: tyrosine-protein kinase Lyk (pY511)
is_a: PR:000002111 ! tyrosine-protein kinase ITK/TSK

id: PR:newterm6
name tyrosine-protein kinase ITK/TSK phosphorylated 1 (human)
definition: A tyrosine-protein kinase ITK/TSK phosphorylated 1 in human. [PMID:7565679]
exact synonym: hITK (pY511)
is_a: PR:newterm5 ! tyrosine-protein kinase ITK/TSK phosphorylated 1
is_a: PR:Q08881 ! tyrosine-protein kinase ITK/TSK (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm5 ! tyrosine-protein kinase ITK/TSK phosphorylated 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

Creb (pS133)
http://www.phosphosite.org/proteinAction.do?id=1489&showAllSites=true

id: PR:newterm7
name: cyclic AMP-responsive element-binding protein phosphorylated 1
definition: A cyclic AMP-responsive element-binding protein 1 that has been post-translationally modified to include a phosphoserine at position 133 of the full-length sequence. [PMID:11988169]
exact synonym: CREB-1
exact synonym: CREB 1
exact synonym: cAMP-responsive element-binding protein 1
is_a: PR:000005854 ! cyclic AMP-responsive element-binding protein 1

id: PR:newterm8
name: cyclic AMP-responsive element-binding protein phosphorylated 1 (human)
definition: A cyclic AMP-responsive element-binding protein phosphorylated 1 in human. [PMID:11988169]
exact synonym: hCREB1 (Ser133) (human)
is_a: PR:newterm7 ! cyclic AMP-responsive element-binding protein phosphorylated 1
is_a: PR:P16220 ! cyclic AMP-responsive element-binding protein phosphorylated 1 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm7 ! cyclic AMP-responsive element-binding protein phosphorylated 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

Crkl (pY207)
http://www.phosphosite.org/proteinAction.do?id=1084&showAllSites=true

Id: PR:newterm9
Name: Crk-like protein phosphorylated 1

Definition: A Crk-like protein that has been post-translationally modified to include a phosphotyrosine at position 207 of the full-length sequence in humans, mice, and rats. [PMID:9053848]
Exact synonym: CRKL
Related synonym: Crkol
Is_a: PR:000005883 ! Crk-like protein

id: PR:newterm10
name: Crkl-like protein phosphorylated 1 (human)
definition: A Crk-like protein phosphorylated 1 in humans. [PMID:9053848]
exact synonym: hCRKL
is_a: PR:newterm9 ! Crk-like protein phosphorylated 1
is_a: PR:P46109 ! Crk-like protein (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm9 ! Crk-like protein phosphorylated 1
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

MAPKAPK 2 (pT334)
http://www.phosphosite.org/proteinAction.do?id=716&showAllSites=true

Id: PR:newterm13
Name: MAP kinase-activated protein kinase 2 phosphorylated 1
Definition: A MAP kinase-activated protein kinase 2 that has been post-translationally modified to include a phosphoserine at position 334 of the full-length sequence and may include additional phosphorylated residues at other point in the protein. [PMID:8846784]
Exact synonym: MAPK-activated protein kinase 2
Exact synonym: MAPKAP kinase 2
Exact synonym: MAPKAPK-2
Exact synonym: MAPKAPK2
Related synonym: MK2
Related synonym: Rps6kc1
Is_a: PR:000010165 ! MAP kinase-activated protein kinase 2

Id: PR:newterm14
Name: MAP kinase-activated protein kinase 2 phosphorylated 1 (human)
Definition: A MAP kinase-activated protein kinase 2 phosphorylated 1 in human. [PMID:8846784]
Exact synonym: hMAPKAPK2
Is_a: PR:newterm13 ! MAP kinase-activated protein kinase 2
is_a: PR:P49137 ! MAP kinase-activated protein kinase 2 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm13 ! MAP kinase-activated protein kinase 2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

NfkB (pS529)
http://www.phosphosite.org/proteinAction.do?id=1012&showAllSites=true

Id: PR:newterm15
Name: transcription factor p65
Definition: A mitogen-activated protein kinase 11 that has been post-translationally modified to include a phosphoserine at position 529 of the full-length sequence in human. [PMID:9792644]
Related synonym: NFKB3
Exact synonym: RELA
Exact synonym: nuclear factor NF-kappa-B p65 subunit
Exact synonym: nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Is_a: PR:000013875

Id: PR:newterm16
Name: transcription factor p65 phosphorylated 1 (human)
Definition: A transcription factor p65 phosphorylated 1 in human. [PMID:8846784]
Exact synonym: hRELA
Is_a: PR:newterm15 ! transcription factor p65
is_a: PR:Q04206 ! transcription factor p65 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm15 ! transcription factor p65
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

MAPK11
http://www.phosphosite.org/proteinAction.do?id=627&showAllSites=true

Id: PR:newterm17
Name: mitogen-activated protein kinase 11
Definition: A mitogen-activated protein kinase 11 that has been post-translationally modified to include a phosphoserine at positions 180 and 182 of the full-length sequence in human. [Citation: http://www.phosphosite.org/proteinAction.do?id=627&showAllSites=true]
Exact synonym: MAP kinase 11
Exact synonym: MAP kinase p38 beta
Exact synonym: MAPK 11
Exact synonym: MAPK11
Related synonym: PRKM11
Related synonym: SAPK2
Exact synonym: mitogen-activated protein kinase p38 beta
Exact synonym: p38-2
Exact synonym: p38b
Exact synonym: stress-activated protein kinase 2
Is_a: PR:000010152 : mitogen-activated protein kinase 11

Id: PR:newterm18
Name: mitogen-activated protein kinase 11 phosphorylated 1 (human)
Definition: A mitogen-activated protein kinase 11 phosphorylated 1 in human. [PMID:8846784]
Exact synonym: hMAPKAPK11
Is_a: PR:newterm17 ! mitogen-activated protein kinase 11
is_a: PR:Q15759 ! mitogen-activated protein kinase 11 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm17 ! mitogen-activated protein kinase 11
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

MAPK12
http://www.phosphosite.org/proteinAction.do?id=658&showAllSites=true

Id: PR:newterm19
Name: mitogen-activated protein kinase 12
Definition: A mitogen-activated protein kinase 12 that has been post-translationally modified to include a phosphoserine at positions 180 and 182 of the full-length sequence in human. [Citation: http://www.phosphosite.org/proteinAction.do?id=658&showAllSites=true]
Exact synonym: ERK-6
Exact synonym: mitogen-activated protein kinase p38 gamma
Exact synonym: stress-activated protein kinase 3
Exact synonym: MAP kinase 12
Exact synonym: MAP kinase p38 gamma
Exact synonym: MAPK 12
Exact synonym: MAPK12
Exact synonym: SAPK3
Exact synonym: extracellular signal-regulated kinase 6
Related synonym: ERK6
Related synonym: SAPK3
Is_a: PR:000010153 : mitogen-activated protein kinase 12

Id: PR:newterm20
Name: mitogen-activated protein kinase 12 phosphorylated 1 (human)
Definition: A mitogen-activated protein kinase 12 phosphorylated 1 in human. [PMID:8846784]
Exact synonym: hMAPKAPK12
Is_a: PR:newterm19 ! mitogen-activated protein kinase 12
is_a: PR:P53778 ! mitogen-activated protein kinase 12 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm19 ! mitogen-activated protein kinase 12
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

MAPK13
http://www.phosphosite.org/proteinAction.do?id=714&showAllSites=true

Id: PR:newterm21
Name: mitogen-activated protein kinase 13
Definition: A mitogen-activated protein kinase 13 that has been post-translationally modified to include a phosphoserine at positions 180 and 182 of the full-length sequence in human. [Citation: http://www.phosphosite.org/proteinAction.do?id=714&showAllSites=true]
Exact synonym: MAP kinase 13
Exact synonym: MAP kinase p38 delta
Exact synonym: MAPK 13
Exact synonym: MAPK13
Related synonym: PRKM13
Related synonym: SAPK4
Related synonym: Serk4
Exact synonym: mitogen-activated protein kinase p38 delta
Exact synonym: stress-activated protein kinase 4
Is_a: PR:000010154 : mitogen-activated protein kinase 13

Id: PR:newterm22
Name: mitogen-activated protein kinase 13 phosphorylated 1 (human)
Definition: A mitogen-activated protein kinase 13 phosphorylated 1 in human. [PMID:8846784]
Exact synonym: hMAPKAPK13
Is_a: PR:newterm21 ! mitogen-activated protein kinase 13
is_a: PR:O15264 ! mitogen-activated protein kinase 13 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm21 ! mitogen-activated protein kinase 13
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

PLCg2 (pY759)
http://www.phosphosite.org/proteinAction.do?id=1202&showAllSites=true

Id: PR:newterm25
Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Definition: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 that has been post-translationally modified to include a phosphoserine at position 759 of the full-length sequence. [PMID:15509800]
Exact synonym: PLC-IV
Exact synonym: PLC-gamma-2
Exact synonym: PLCG2
Exact synonym: phosphoinositide phospholipase C-gamma-2
Exact synonym: phospholipase C-IV
Exact synonym: phospholipase C-gamma-2
Is_a: PR:000012837 : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

Id: PR:newterm26
Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human)
Definition: A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 phosphorylated in human. [PMID:15509800]
Exact synonym: hPLCG2
Is_a: PR:newterm25! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
is_a: PR:P16885 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm25 ! 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

S6 (pS235)
http://www.phosphosite.org/proteinAction.do?id=1040&showAllSites=true

Id: PR:newterm27
Name: 40s ribosomal protein s6
Definition: A 40s ribosomal protein s6 that has been post-translationally modified to include a phosphoserine at position 235 of the full-length sequence. [PMID:15471950]
Exact synonym: RPS6
Exact synonym: phosphoprotein NP33
Is_a: PR:000014281 : 40s ribosomal protein s6

Id: PR:newterm28
Name: 40s ribosomal protein s6 (human)
Definition: A 40s ribosomal protein s6 phosphorylated in human [PMID:15471950]
Exact synonym: hRPS6
Is_a: PR:newterm27! 40s ribosomal protein s6
is_a: PR:P62753 ! 40s ribosomal protein s6 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm27 ! 40s ribosomal protein s6
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

Shp2 (pY580)
http://www.phosphosite.org/proteinAction.do?id=1103&showAllSites=true

Id: PR:newterm29
Name: tyrosine-protein phosphatase non-receptor type 11
Definition: A tyrosine-protein phosphatase non-receptor type 11 that has been post-translationally modified to include a phosphoserine at position 584 of the full-length sequence. [PMID:20855525]
Human, mouse and rat is located at 584 in the full length sequence. In human, mouse and rat isoform 2 it is located at position 580.
Exact synonym: PTP-1D
Exact synonym: PTP-2C
Related synonym: PTP2C
Exact synonym: PTPN11
Exact synonym: SH-PTP2
Exact synonym: SH-PTP3
Exact synonym: SHP-2
Related synonym: SHPTP2
Exact synonym: protein-tyrosine phosphatase 1D
Exact synonym: protein-tyrosine phosphatase 2C
Exact synonym: protein-tyrosine phosphatase SYP
Exact synonym: shp2
Is_a: PR:000013449 : tyrosine-protein phosphatase non-receptor type 11

Id: PR:newterm30
Name: tyrosine-protein phosphatase non-receptor type 11 (human)
Definition: tyrosine-protein phosphatase non-receptor type 11 phosphorylated in human. [PMID:20855525]
Exact synonym: hPTPN11
Is_a: PR:newterm29 ! tyrosine-protein phosphatase non-receptor type 11
is_a: PR:Q06124 ! tyrosine-protein phosphatase non-receptor type 11 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm29 ! tyrosine-protein phosphatase non-receptor type 11
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

SLP-76 (BLNK) (pY128)
http://www.phosphosite.org/proteinAction.do?id=1188&showAllSites=true

Id: PR:newterm31
Name: lymphocyte cytosolic protein 2
Definition: A lymphocyte cytosolic protein 2 that has been post-translationally modified to include a phosphoserine at position 128 of the full-length sequence. [PMID:8892604]
Exact synonym: LCP2
Exact synonym: SH2 domain-containing leukocyte protein of 76 kDa
Exact synonym: SLP-76 tyrosine phosphoprotein
Exact synonym: SLP76
Is_a: PR:000009733 : lymphocyte cytosolic protein 2

Id: PR:newterm32
Name: lymphocyte cytosolic protein 2 (human)
Definition: A lymphocyte cytosolic protein 2 phosphorylated in human. [PMID:8892604]
Exact synonym: hLCP2
Is_a: PR:newterm31 ! lymphocyte cytosolic protein 2
is_a: PR:Q13094 ! lymphocyte cytosolic protein 2 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm32 ! lymphocyte cytosolic protein 2
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

STAT3 (pY418)
http://www.phosphosite.org/proteinAction.do?id=1050&showAllSites=true

Id: PR:newterm33
Name: signal transducer and activator of transcription 3
Definition: A signal transducer and activator of transcription 3 that has been post-translationally modified to include a phosphoserine at position 705 of the full-length sequence. [PMID:9531474, 9287210]
Related synonym: APRF
Exact synonym: STAT3
Exact synonym: acute-phase response factor
Is_a: PR:000002089 : signal transducer and activator of transcription 3

Id: PR:newterm34
Name: signal transducer and activator of transcription 3 (human)
Definition: A signal transducer and activator of transcription 3 phosphorylated in human. [PMID: 9531474, 9287210]
Exact synonym: hSTAT3
Is_a: PR:newterm33 ! signal transducer and activator of transcription 3
is_a: PR:P40763 ! signal transducer and activator of transcription 3 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm33 ! signal transducer and activator of transcription 3
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

STAT5 (pY694)
http://www.phosphosite.org/proteinAction.do?id=1052&showAllSites=true

Id: PR:newterm35
Name: signal transducer and activator of transcription 5a
Definition: A signal transducer and activator of transcription 5a that has been post-translationally modified to include a phosphoserine at position 694 of the full-length sequence. [PMID:7925280]
Related synonym: Mgf
Related synonym: Mpf
Related synonym: STAT5
Exact synonym: STAT5A
Exact synonym: mamry gland factor
Is_a: PR:000002091 : signal transducer and activator of transcription 5a

Id: PR:newterm36
Name: signal transducer and activator of transcription 5a (human)
Definition: A signal transducer and activator of transcription 5a phosphorylated in human. [PMID:7925280]
Exact synonym: hSTAT5A
Is_a: PR:newterm35 ! signal transducer and activator of transcription 5a
is_a: PR:P42229 ! signal transducer and activator of transcription 3 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm35 ! signal transducer and activator of transcription 5a
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens

p-RPS6 (S235/S236)
http://www.phosphosite.org/proteinAction.do?id=1040&showAllSites=true

Id: PR:newterm51
Name: 40s ribosomal protein S6
Definition: A 40s ribosomal protein S6 that has been post-translationally modified to include phosphoserines at positions 235 and 236 of the full-length sequence. [PMID:15471950]
Exact synonym: RPS6
Exact synonym: phosphoprotein NP33
Is_a: PR:000014281 : 40s ribosomal protein S6

Id: PR:newterm52
Name: 40s ribosomal protein S6 (human)
Definition: A 40s ribosomal protein S6 phosphorylated in human. [PMID:]
Exact synonym: hRPS6
Is_a: PR:newterm51 ! 40s ribosomal protein S6
is_a: PR:P62753 ! 40s ribosomal protein S6 (human) [ideally this second relationship should be inferred by a reasoner]
intersection_of: PR:newterm51 ! 40s ribosomal protein S6
intersection_of: only_in_taxon NCBITaxon:9606 ! Homo sapiens
relationship: only_in_taxon NCBITaxon:9606 ! Homo sapiens