Complexes used by CL/Immport
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[Term]
id: GO:0019814
name: immunoglobulin complex
namespace: cellular_component
def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0043234 ! protein complex
[Term]
id: GO:0019815
name: B cell receptor complex
namespace: cellular_component
alt_id: GO:0042570
def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149]
comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "antibody" RELATED [GOC:mah]
synonym: "B cell receptor accessory molecule complex" RELATED []
synonym: "B lymphocyte receptor complex" EXACT []
synonym: "B-cell receptor complex" EXACT []
synonym: "B-lymphocyte receptor complex" EXACT []
synonym: "BCR complex" EXACT []
synonym: "immunoglobulin complex, membrane bound" EXACT []
is_a: GO:0019814 ! immunoglobulin complex
is_a: GO:0043235 ! receptor complex
[Term]
id: GO:0033001
name: Fc-gamma receptor III complex
namespace: cellular_component
def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532]
synonym: "FcgRIII complex" EXACT []
synonym: "IgG receptor complex" BROAD []
synonym: "immunoglobulin G receptor complex" BROAD []
is_a: GO:0032997 ! Fc receptor complex
[Term]
id: GO:0035369
name: pre-B cell receptor complex
namespace: cellular_component
def: "An immunoglobulin-like complex that is present in at least the plasma membrane of pre-B cells, and that is composed of two identical immunoglobulin heavy chains and two surrogate light chains, each composed of the lambda-5 and VpreB proteins, and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781765196, PMID:16464608, PMID:17306522]
comment: Despite its name, the pre-BCR is not a receptor complex, as it appears to provide a low level of signal not dependent on a ligand, but rather simply on correct assembly of the complex as a measure for correct Ig heavy chain recombination and folding. A significant proportion of pre-BCR complexes fail to reach the cell surface, and in some cases may provide their signaling function from the trans-Golgi network or lysosome.
synonym: "pre-BCR" EXACT []
is_a: GO:0043234 ! protein complex
[Term]
id: GO:0042101
name: T cell receptor complex
namespace: cellular_component
def: "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149]
synonym: "T lymphocyte receptor complex" EXACT []
synonym: "T-cell receptor complex" EXACT []
synonym: "T-lymphocyte receptor complex" EXACT []
synonym: "TCR" RELATED []
xref: Wikipedia:T_cell_receptor
is_a: GO:0043235 ! receptor complex
[Term]
id: GO:0042105
name: alpha-beta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149]
synonym: "alpha-beta T lymphocyte receptor complex" EXACT []
synonym: "alpha-beta T-cell receptor complex" EXACT []
synonym: "alpha-beta T-lymphocyte receptor complex" EXACT []
synonym: "alpha-beta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex
[Term]
id: GO:0042106
name: gamma-delta T cell receptor complex
namespace: cellular_component
def: "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149]
synonym: "gamma-delta T lymphocyte receptor complex" EXACT []
synonym: "gamma-delta T-cell receptor complex" EXACT []
synonym: "gamma-delta T-lymphocyte receptor complex" EXACT []
synonym: "gamma-delta TCR complex" EXACT []
is_a: GO:0042101 ! T cell receptor complex
[Term]
id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]
is_a: GO:0043234 ! protein complex
[Term]
id: GO:0042612
name: MHC class I protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]
comment: See also the cellular component term 'MHC class I peptide loading complex ; GO:0042824'.
is_a: GO:0042611 ! MHC protein complex
[Term]
id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def: "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]
is_a: GO:0042611 ! MHC protein complex
[Term]
id: GO:0043384
name: pre-T cell receptor complex
namespace: cellular_component
def: "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932]
synonym: "pre-T lymphocyte receptor complex" EXACT []
synonym: "pre-T-cell receptor complex" EXACT []
synonym: "pre-T-lymphocyte receptor complex" EXACT []
synonym: "pre-TCR complex" EXACT []
is_a: GO:0043235 ! receptor complex
[Term]
id: GO:0071735
name: IgG immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgG immunoglobulin complex has the function of antigen binding if a suitable antigen is available. Also, IgG isotypes vary by species.
synonym: "IgG1" NARROW [GOC:add]
synonym: "IgG2" NARROW [GOC:add]
synonym: "IgG2a" NARROW [GOC:add]
synonym: "IgG2b" NARROW [GOC:add]
synonym: "IgG2c" NARROW [GOC:add]
synonym: "IgG3" NARROW [GOC:add]
synonym: "IgG4" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex
[Term]
id: GO:0071738
name: IgD immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:11282392]
comment: Note that an IgD immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex
[Term]
id: GO:0071742
name: IgE immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196]
comment: Note that an IgE immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex
[Term]
id: GO:0071745
name: IgA immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:16362985]
comment: Note that an IgA immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
synonym: "IgA1 antibody" NARROW [GOC:add]
synonym: "IgA2 antibody" NARROW [GOC:add]
is_a: GO:0019814 ! immunoglobulin complex
[Term]
id: GO:0071753
name: IgM immunoglobulin complex
namespace: cellular_component
def: "A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, ISBN:0781765196, PMID:20176268]
comment: Note that an IgM immunoglobulin complex has the function of antigen binding if a suitable antigen is available.
is_a: GO:0019814 ! immunoglobulin complex