I had a poke round and got it back in my head, sort of
It's a follow-up to the linked GO annotation tracker item -- Uniprot maps their SP-SL term "secreted" to GO "extracellular region", never mind how many fungal and bacterial proteins are secreted into the periplasmic space or cell wall.
In the spreadsheet (now at Dropbox/pombase/ontologies/GO/GO_annotation_misc/pombe_secreted_proteins_MAH_notes.xlsx) I looked at the pombe genes that have the SP-SL "secreted" keyword. I think the idea was that you would use that info to decide whether to have UniProt remove the keyword from their entry, or to keep filtering that SP-SL:GO mapping for our annotations.
I'm fairly sure that if we do nothing at this point, we avoid some dodgy annotations to extracellular, and at worst miss a handful of good ones.
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I can't remember what needs to happen with this!
I had a poke round and got it back in my head, sort of
It's a follow-up to the linked GO annotation tracker item -- Uniprot maps their SP-SL term "secreted" to GO "extracellular region", never mind how many fungal and bacterial proteins are secreted into the periplasmic space or cell wall.
In the spreadsheet (now at Dropbox/pombase/ontologies/GO/GO_annotation_misc/pombe_secreted_proteins_MAH_notes.xlsx) I looked at the pombe genes that have the SP-SL "secreted" keyword. I think the idea was that you would use that info to decide whether to have UniProt remove the keyword from their entry, or to keep filtering that SP-SL:GO mapping for our annotations.
I'm fairly sure that if we do nothing at this point, we avoid some dodgy annotations to extracellular, and at worst miss a handful of good ones.
OK, I'll take a look at some point. Nice thing about these is the longer you leave 'em, the less there is to do.
Val