In generic audio subsystem, FormatWAV.cpp has hardcoded sampling rates (line 63), mutators utilizing other sampling rates such as the Strength Rune and Soul Harvest will cause an app error. Since the underlying sound driver should be versatile enough to take arbitrary rates this test could be removed.
SDLAudio should handle any sampling rate correctly. Try it out instead of Audio. SDLAudio isn't fully implemented, but it works really well just the same.