The game Quattro (can be downloaded from MRC), crashes with:
File not open in 309
when it is started with any MSX-AUDIO inserted. It works normally on a real MSX, I verified.
It crashes right after the title screen is displayed, after the system check. Using the same emulated MSX but without an MSX-AUDIO makes the game run just fine.
It also crashes in a similar way on blueMSX, but there it says:
Bad file mode in 321
according to John van Poelgeest on MRC: http://www.msx.org/forumtopicl6756.html