#1824 ultimobranchial bodies


Please consider amending the definition of "abnormal ultimobranchial body morphology [MP:0003955]" to read as:

DEF: any structural anomaly of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth
SYN: abnormal postbranchial body morphology
SYN: abnormal telobranchial body morphology
SYN: abnormal telopharyngeal body morphology
SYN: abnormal ultimobranchial gland morphology
SYN: abnormal ultimopharyngeal body morphology
SYN: abnormal ultimopharyngeal gland morphology
SYN: abnormal corpus ultimopharyngeum morphology

Then add new term:

persistent ultimobranchial bodies
DEF: partial or complete failure of the ultimobranchial bodies to fuse with the ventral thyroid primordium; as a result, ultimobranchial bodies remain as unilateral or bilateral vesicles composed exclusively of calcitonin-producing cells


The pharyngeal pouches and clefts: Development, evolution, structure and derivatives. Semin Cell Dev Biol. 2010 May;21(3):325-32. doi: 10.1016/j.semcdb.2010.01.022. PMID: 20144910

Dorland's Medical Dictionary http://web.archive.org/web/20100908075729/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000013743.htm





  • Cynthia Smith

    Cynthia Smith - 2014-09-12
    • status: open --> closed-accepted
    • assigned_to: Cynthia Smith
    • Group: -->
  • Cynthia Smith

    Cynthia Smith - 2014-09-12

    Definitions and synonyms are amended.
    New term added:
    'persistent ultimobranchial bodies' MP:0013290


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