#1824 ultimobranchial bodies

[Anna Anagnostopoulos]

Please consider amending the definition of "abnormal ultimobranchial body morphology [MP:0003955]" to read as:

DEF: any structural anomaly of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth
SYN: abnormal postbranchial body morphology
SYN: abnormal telobranchial body morphology
SYN: abnormal telopharyngeal body morphology
SYN: abnormal ultimobranchial gland morphology
SYN: abnormal ultimopharyngeal body morphology
SYN: abnormal ultimopharyngeal gland morphology
SYN: abnormal corpus ultimopharyngeum morphology

Then add new term:

persistent ultimobranchial bodies
DEF: partial or complete failure of the ultimobranchial bodies to fuse with the ventral thyroid primordium; as a result, ultimobranchial bodies remain as unilateral or bilateral vesicles composed exclusively of calcitonin-producing cells

SOURCES:

The pharyngeal pouches and clefts: Development, evolution, structure and derivatives. Semin Cell Dev Biol. 2010 May;21(3):325-32. doi: 10.1016/j.semcdb.2010.01.022. PMID: 20144910

Dorland's Medical Dictionary http://web.archive.org/web/20100908075729/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000013743.htm

http://books.google.gr/books?id=vjctIKeMh3sC&pg=PT44&lpg=PT44&dq=persistent+ultimobranchial&source=bl&ots=w57JULaBK6&sig=twvB6G-dOF0yDMxx_4tFys-8Tro&hl=en&sa=X&ei=dpeEU5XuEobMsQSPuoKYBA&redir_esc=y#v=onepage&q=persistent%20ultimobranchial&f=false

Thanks

Anna

[Cynthia Smith]

Definitions and synonyms are amended.
New term added:
'persistent ultimobranchial bodies' MP:0013290