#1286 abnormal podocyte motility


Please add:

abnormal podocyte motility
SYN: abnormal podocyte migration
SYN: abnormal podocyte foot process motility
DEF: any anomaly in the ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM); motility refers to the dynamic reorganization of the interdigitating FP structure in vivo , and to the cell migration of cultured podocytes in vitro that is seen as surrogate for the former; alterations in podocyte motility are considered to underlie foot process effacement, with changes in the leading edge of the cell and its interactions with the GBM; a rather stationary podocyte phenotype is believed to reflect a stable FP structure with intact slit diaphragms, whereas hypermotility is believed to promote the development of FP effacement and proteinuria

Then, add increased and decreased podocyte motility children terms

NOTE: the definition above has been compiled from several sources

increased podocyte motility (SYN: podocyte hypermotility) is believed to promote the development of FP effacement and proteinuria

decreased podocyte motility (SYN: podocyte hypomotility) is believed to stabilize the podocyte FP architecture and protect from effacement and proteinuria




  • Cynthia Smith

    Cynthia Smith - 2012-12-20
    • assigned_to: nobody --> cynthiasmith
    • status: open --> closed-accepted
  • Cynthia Smith

    Cynthia Smith - 2012-12-20

    New terms added:

    abnormal podocyte motility MP:0011865
    increased podocyte motility MP:0011866
    decreased podocyte motility MP:0011867


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