Screenshot instructions:
Windows
Mac
Red Hat Linux
Ubuntu
Click URL instructions:
Rightclick on ad, choose "Copy Link", then paste here →
(This may not be possible with some types of ads)
From: <cjm@fr...>  20080625 15:16:34

* Created object of type obo:TERM with id SBO:0000369 * Populated new object SBO:0000369 (macro) * Changed name of SBO:0000369 from "SBO:0000369" to "gene regulatory region" * Set definition of SBO:0000369 to "Region of a gene that are involved in the modulation of the expression of the gene. " * Created link SBO:0000369 OBO_REL:is_a> SBO:0000354 * Assigned namespace "sbo" to SBO:0000369 * Deleted SBO:0000243 OBO_REL:is_a> SBO:0000241 * Created link SBO:0000243 OBO_REL:is_a> SBO:0000354 
From: <cjm@fr...>  20080705 16:41:11

* Deleted SBO:0000203 OBO_REL:is_a> SBO:0000176 * org.geneontology.oboedit.history.ObsoleteObjectHistoryItem@... * Changed name of SBO:0000204 from "replication" to "dna replication" * Deleted SBO:0000204 OBO_REL:is_a> SBO:0000203 
From: <cjm@fr...>  20080716 11:20:28

* Created object of type obo:TERM with id SBO:0000370 * Created object of type obo:TERM with id SBO:0000371 * Created object of type obo:TERM with id SBO:0000372 * Created object of type obo:TERM with id SBO:0000373 * Populated new object SBO:0000370 (macro) * Changed name of SBO:0000370 from "SBO:0000370" to "Michaelis constant in nonequilibrium situation" * Set definition of SBO:0000370 to "Michaelis constant derived or experimentally measured under nonequilibrium conditions." * Created link SBO:0000370 OBO_REL:is_a> SBO:0000027 * Assigned namespace "sbo" to SBO:0000370 * Populated new object SBO:0000371 (macro) * Changed name of SBO:0000371 from "SBO:0000371" to "Michaelis constant in quasisteady state situation" * Set definition of SBO:0000371 to "Michaelis constant derived using a steadystate assumption for enzymesubstrate and enzymeproduct intermediates. For example see BriggsHaldane equation (SBO:0000031)." * Created link SBO:0000371 OBO_REL:is_a> SBO:0000370 * Assigned namespace "sbo" to SBO:0000371 * Populated new object SBO:0000372 (macro) * Changed name of SBO:0000372 from "SBO:0000372" to "Michaelis constant in irreversible situation" * Set definition of SBO:0000372 to "Michaelis constant derived assuming enzymesubstrate and enzymeproduct intermediates are formed in consecutive irreversible reactions. The constant K is the ratio of the forward rate constants. For example see Van SlykeCullen equation (SBO:0000030)." * Created link SBO:0000372 OBO_REL:is_a> SBO:0000370 * Assigned namespace "sbo" to SBO:0000372 * Populated new object SBO:0000373 (macro) * Changed name of SBO:0000373 from "SBO:0000373" to "Michaelis constant in fast equilibrium situation" * Set definition of SBO:0000373 to "Michaelis constant where the steps leading to the constant are much faster than subsequent steps, and are assumed to be in quasiequilibrium. K is equivalent to an equilibrium constant. For example see HenriMichaelisMenten equation (SBO:0000029)." * Created link SBO:0000373 OBO_REL:is_a> SBO:0000027 * Assigned namespace "sbo" to SBO:0000373 * Changed definition of SBO:0000029 from "First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois G????n????rales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333369. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" to "First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois G???????n???????rales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333369. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000373">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" * Changed definition of SBO:0000030 from "Ratelaw presented in "Donald D. Van Slyke and Glenn E. Cullen. The mode of action of urease and of enzymes in general. J. Biol. Chem., Oct 1914, 19: 141180". It assumes that the enzymatic reaction occurs as two irreversible steps.E+S > ES > E+P. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since K now represents the ration between the production rate and the association rate of the enzyme and the substrate. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" to "Ratelaw presented in "Donald D. Van Slyke and Glenn E. Cullen. The mode of action of urease and of enzymes in general. J. Biol. Chem., Oct 1914, 19: 141180". It assumes that the enzymatic reaction occurs as two irreversible steps.E+S > ES > E+P. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since K now represents the ration between the production rate and the association rate of the enzyme and the substrate. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000372">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" * Changed definition of SBO:0000031 from "Ratelaw presented in "G.E. Briggs and J.B.S. Haldane (1925) A note on the kinetics of enzyme action, Biochem. J., 19: 338339". It is a general rate equation that does not require the restriction of equilibrium of HenriMichaelisMenten or irreversible reactions of Van Slyke, but instead make the hypothesis that the complex enzymesubstrate is in quasisteadystate. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since Km now represents a pseudoequilibrium constant, and is equal to the ratio between the rate of consumption of the complex (sum of dissociation of substrate and generation of product) and the association rate of the enzyme and the substrate. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Km</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Km</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" to "Ratelaw presented in "G.E. Briggs and J.B.S. Haldane (1925) A note on the kinetics of enzyme action, Biochem. J., 19: 338339". It is a general rate equation that does not require the restriction of equilibrium of HenriMichaelisMenten or irreversible reactions of Van Slyke, but instead make the hypothesis that the complex enzymesubstrate is in quasisteadystate. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since Km now represents a pseudoequilibrium constant, and is equal to the ratio between the rate of consumption of the complex (sum of dissociation of substrate and generation of product) and the association rate of the enzyme and the substrate. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000371">Km</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Km</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" * Deleted SBO:0000263 OBO_REL:is_a> SBO:0000256 * Created link SBO:0000263 OBO_REL:is_a> SBO:0000308 * Changed name of SBO:0000308 from "equilibrium characteristic" to "equilibrium or steadystate characteristic" 
From: <cjm@fr...>  20080718 14:33:12

* Changed definition of SBO:0000147 from "Temperature is the physical property of a system which underlies the common notions of "hot" and "cold", the material with the higher temperature is said to be hotter. Temperature is a measure related to the average kinetic energy of the particles in a substance. The 10th Conf??rence G??n??rale des Poids et Mesures decides to define the thermodynamic temperature scale by choosing the triple point of water as the fundamental fixed point, and assigning to it the temperature 273,16 degrees Kelvin, exactly (0.01 degree Celsius)." to "Temperature is the physical property of a system which underlies the common notions of "hot" and "cold", the material with the higher temperature is said to be hotter. Temperature is a quantity related to the average kinetic energy of the particles in a substance. The 10th Conference Generale des Poids et Mesures decided to define the thermodynamic temperature scale by choosing the triple point of water as the fundamental fixed point, and assigning to it the temperature 273,16 degrees Kelvin, exactly (0.01 degree Celsius)." * Changed name of SBO:0000227 from "density" to "mass density" * Changed definition of SBO:0000227 from "Measure of mass per unit of size." to "Quantity of mass per unit of size." * Changed definition of SBO:0000228 from "Measure of mass per unit of volume." to "Quantity of mass per unit of volume." * Changed definition of SBO:0000229 from "Measure of mass per unit of surface." to "Units of mass per unit of surface." * Changed definition of SBO:0000230 from "Measure of mass per unit of length." to "Quantity of mass per unit of length." 
From: <cjm@fr...>  20080807 11:44:47

* Changed name of SBO:0000342 from "Molecular interaction" to "molecular interaction" 
From: <cjm@fr...>  20080812 20:45:55

* Changed definition of SBO:0000000 from "Set of relational controlled vocabularies intended to increase the semantic content of quantitative efforts in Systems Biology. " to "Set of relational controlled vocabularies intended to increase the semantic content of quantitative efforts in Systems Biology." * Changed definition of SBO:0000029 from "First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois G???????n???????rales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333369. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000373">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" to "First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois G??n??rales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333369. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000373">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" 
From: <cjm@fr...>  20080909 14:49:38

* Changed name of SBO:0000309 from "dissociation charateristic" to "dissociation characteristic" 
From: <cjm@fr...>  20081216 15:43:06

* Created object of type obo:TERM with id SBO:0000374 * Created object of type obo:TERM with id SBO:0000375 * Created object of type obo:TERM with id SBO:0000376 * Created object of type obo:TERM with id SBO:0000377 * Created object of type obo:TERM with id SBO:0000378 * Created object of type obo:TERM with id SBO:0000379 * Created object of type obo:TERM with id SBO:0000380 * Created object of type obo:TERM with id SBO:0000381 * Created object of type obo:TERM with id SBO:0000382 * Created object of type obo:TERM with id SBO:0000383 * Created object of type obo:TERM with id SBO:0000384 * Created object of type obo:TERM with id SBO:0000385 * Created object of type obo:TERM with id SBO:0000386 * Created object of type obo:TERM with id SBO:0000387 * Created object of type obo:TERM with id SBO:0000388 * Created object of type obo:TERM with id SBO:0000389 * Created object of type obo:TERM with id SBO:0000390 * Created object of type obo:TERM with id SBO:0000391 * Created object of type obo:TERM with id SBO:0000392 * Created object of type obo:TERM with id SBO:0000393 * Created object of type obo:TERM with id SBO:0000394 * Created object of type obo:TERM with id SBO:0000395 * Created object of type obo:TERM with id SBO:0000396 * Created object of type obo:TERM with id SBO:0000397 * Created object of type obo:TERM with id SBO:0000398 * Created object of type obo:TERM with id SBO:0000399 * Created object of type obo:TERM with id SBO:0000400 * Created object of type obo:TERM with id SBO:0000401 * Created object of type obo:TERM with id SBO:0000402 * Created object of type obo:TERM with id SBO:0000403 * Created object of type obo:TERM with id SBO:0000404 * Created object of type obo:TERM with id SBO:0000405 * Created object of type obo:TERM with id SBO:0000406 * Populated new object SBO:0000374 (macro) * Changed name of SBO:0000374 from "SBO:0000374" to "relationship" * Set definition of SBO:0000374 to "connectedness between entities and/or interactions representing their relatedness or influence." * Created link SBO:0000374 OBO_REL:is_a> SBO:0000231 * Assigned namespace "sbo" to SBO:0000374 * Populated new object SBO:0000375 (macro) * Changed name of SBO:0000375 from "SBO:0000375" to "process" * Set definition of SBO:0000375 to "A sequential series of actions, motions, or occurrences, such as chemical reactions, that affect one or more entities in a phenomenologically characteristic manner." * Created link SBO:0000375 OBO_REL:is_a> SBO:0000231 * Assigned namespace "sbo" to SBO:0000375 * Populated new object SBO:0000376 (macro) * Changed name of SBO:0000376 from "SBO:0000376" to "hydrolysis" * Set definition of SBO:0000376 to "Decomposition of a compound by reaction with water, where the hydroxyl and H groups are incorporated into different products" * Created link SBO:0000376 OBO_REL:is_a> SBO:0000176 * Assigned namespace "sbo" to SBO:0000376 * Populated new object SBO:0000377 (macro) * Changed name of SBO:0000377 from "SBO:0000377" to "isomerisation" * Set definition of SBO:0000377 to "A reaction in which the principal reactant and principal product are isomers of each other" * Created link SBO:0000377 OBO_REL:is_a> SBO:0000176 * Assigned namespace "sbo" to SBO:0000377 * Populated new object SBO:0000378 (macro) * Changed name of SBO:0000378 from "SBO:0000378" to "enzymatic rate law for inhibition of irreversible unireactant enzymes by competing substrates" * Set definition of SBO:0000378 to "Inhibition of a unireactant enzyme by competing substrates (Sa) that bind to the free enzyme on the same binding site. The enzyme does not catalyse the reactions in both directions. [See CornishBowden Fundementals of Enzyme Kinetics (3rd Edition 2004): Ch5.6, pp127] <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000206">Sa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ksa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <sum/> <bvar><ci> i </ci></bvar> <lowlimit><cn type="integer"> 1 </cn></lowlimit> <uplimit><ci> n </ci></uplimit> <apply> <divide/> <apply> <selector/> <ci type="vector">Sa</ci> <ci> i </ci> </apply> <apply> <selector/> <ci type="vector">Ksa</ci> <ci> i </ci> </apply> </apply> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " * Created link SBO:0000378 OBO_REL:is_a> SBO:0000270 * Assigned namespace "sbo" to SBO:0000378 * Populated new object SBO:0000379 (macro) * Changed name of SBO:0000379 from "SBO:0000379" to "enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two nonexclusive inhibitors" * Set definition of SBO:0000379 to "Inhibition of a unireactant enzyme by two inhibitors that can bind once to the free enzyme and preclude the binding of the substrate. Binding of one inhibitor may affect binding of the other, or not. The enzymes do not catalyse the reactions in both directions. See Segel I., Enzyme Kinetics, WileyInterscience,1993, ISBN 0471303097, Chapter 8, System B3, pp481 <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000383">a</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki2</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I1</ci> <ci>Ki1</ci> </apply> <apply> <divide/> <ci>I2</ci> <ci>Ki2</ci> </apply> <apply> <divide/> <apply> <times/> <ci>I1</ci> <ci>I2</ci> </apply> <apply> <times/> <ci>a</ci> <ci>Ki1</ci> <ci>Ki2</ci> </apply> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " * Created link SBO:0000379 OBO_REL:is_a> SBO:0000269 * Assigned namespace "sbo" to SBO:0000379 * Populated new object SBO:0000380 (macro) * Changed name of SBO:0000380 from "SBO:0000380" to "biochemical coefficient" * Set definition of SBO:0000380 to "number used as a multiplicative or exponential factor for quantities, expressions or functions" * Created link SBO:0000380 OBO_REL:is_a> SBO:0000256 * Assigned namespace "sbo" to SBO:0000380 * Populated new object SBO:0000381 (macro) * Changed name of SBO:0000381 from "SBO:0000381" to "biochemical proportionality coefficient" * Set definition of SBO:0000381 to "A multiplicative factor for quantities, expressions or functions " * Created link SBO:0000381 OBO_REL:is_a> SBO:0000380 * Assigned namespace "sbo" to SBO:0000381 * Populated new object SBO:0000382 (macro) * Changed name of SBO:0000382 from "SBO:0000382" to "biochemical exponential coefficient" * Set definition of SBO:0000382 to "number used as an exponential factor for quantities, expressions or functions " * Created link SBO:0000382 OBO_REL:is_a> SBO:0000380 * Assigned namespace "sbo" to SBO:0000382 * Populated new object SBO:0000383 (macro) * Changed name of SBO:0000383 from "SBO:0000383" to "biochemical cooperative inhibition coefficient" * Set definition of SBO:0000383 to "The coefficient used to quantify the effect on inhibition constants of multiple inhibitors binding nonexclusively to the enzyme." * Created link SBO:0000383 OBO_REL:is_a> SBO:0000381 * Assigned namespace "sbo" to SBO:0000383 * Populated new object SBO:0000384 (macro) * Changed name of SBO:0000384 from "SBO:0000384" to "biochemical inhibitory proportionality coefficient" * Set definition of SBO:0000384 to "Coefficient that quantifies the effect on inhibition constants of either binding of multiple substrates or inhibitors." * Created link SBO:0000384 OBO_REL:is_a> SBO:0000381 * Assigned namespace "sbo" to SBO:0000384 * Populated new object SBO:0000385 (macro) * Changed name of SBO:0000385 from "SBO:0000385" to "biochemical cooperative inhibitor substrate coefficient" * Set definition of SBO:0000385 to "The coefficient that describes the proportional change of Ks or Ki when inhibitor or substrate is bound, respectively, to the enzyme." * Created link SBO:0000385 OBO_REL:is_a> SBO:0000381 * Assigned namespace "sbo" to SBO:0000385 * Populated new object SBO:0000386 (macro) * Changed name of SBO:0000386 from "SBO:0000386" to "enzymatic rate law for inhibition of irreversible unireactant enzymes by single competing substrate" * Set definition of SBO:0000386 to "Inhibition of a unireactant enzyme by a competing substrate (Sa) that binds to the free enzyme on the same binding site. The enzyme does not catalyse the reactions in both directions. [See CornishBowden Fundementals of Enzyme Kinetics (3rd Edition 2004): Ch5.6, pp127] <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000206">Sa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ksa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>Sa</ci> <ci>Ksa</ci> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " * Created link SBO:0000386 OBO_REL:is_a> SBO:0000378 * Assigned namespace "sbo" to SBO:0000386 * Populated new object SBO:0000387 (macro) * Changed name of SBO:0000387 from "SBO:0000387" to "enzymatic rate law for competitive inhibition of irreversible unireactant enzyme by product" * Set definition of SBO:0000387 to "Inhibition of a unireactant enzyme by a competing product (P) that binds to the free enzyme on the same binding site. The enzyme does not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">P</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Kp</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>P</ci> <ci>Kp</ci> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " * Created link SBO:0000387 OBO_REL:is_a> SBO:0000270 * Assigned namespace "sbo" to SBO:0000387 * Populated new object SBO:0000388 (macro) * Changed name of SBO:0000388 from "SBO:0000388" to "enzymatic rate law for inhibition of irreversible unireactant enzymes by single competing substrate with product inhibition" * Set definition of SBO:0000388 to "Inhibition of a unireactant enzyme by a competing substrate (Sa) that binds to the free enzyme on the same binding site, and competitive inhibition by a product (P) and an alternative product (Pa). The enzyme does not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000206">Sa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ksa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Kp</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Kpa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000011">P</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000206">Pa</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>Sa</ci> <ci>Ksa</ci> </apply> <apply> <divide/> <ci>P</ci> <ci>Kpa</ci> </apply> <apply> <divide/> <ci>Pa</ci> <ci>Kpa</ci> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " * Created link SBO:0000388 OBO_REL:is_a> SBO:0000378 * Assigned namespace "sbo" to SBO:0000388 * Populated new object SBO:0000389 (macro) * Changed name of SBO:0000389 from "SBO:0000389" to "toggle switch parameter" * Set definition of SBO:0000389 to "A parameter with a discrete set of values which can be alternated or switched between." * Created link SBO:0000389 OBO_REL:is_a> SBO:0000002 * Assigned namespace "sbo" to SBO:0000389 * Populated new object SBO:0000390 (macro) * Changed name of SBO:0000390 from "SBO:0000390" to "boolean toggle switch parameter" * Set definition of SBO:0000390 to "A parameter that has precisely two discrete values which may be switched between. Usually for the boolean parameter these are indicated as '0 or 1' or 'True or False'." * Created link SBO:0000390 OBO_REL:is_a> SBO:0000389 * Assigned namespace "sbo" to SBO:0000390 * Populated new object SBO:0000391 (macro) * Changed name of SBO:0000391 from "SBO:0000391" to "steady state expression" * Set definition of SBO:0000391 to "A mathematical expression that describes a steady state situation" * Created link SBO:0000391 OBO_REL:is_a> SBO:0000064 * Assigned namespace "sbo" to SBO:0000391 * Populated new object SBO:0000392 (macro) * Changed name of SBO:0000392 from "SBO:0000392" to "equivalence" * Set definition of SBO:0000392 to "Term to signify those material or conceptual entities that are identical in some respect within a frame of reference" * Created link SBO:0000392 OBO_REL:is_a> SBO:0000374 * Assigned namespace "sbo" to SBO:0000392 * Populated new object SBO:0000393 (macro) * Changed name of SBO:0000393 from "SBO:0000393" to "production" * Set definition of SBO:0000393 to "A process that leads to the generation of a material or conceptual entity. " * Created link SBO:0000393 OBO_REL:is_a> SBO:0000168 * Assigned namespace "sbo" to SBO:0000393 * Populated new object SBO:0000394 (macro) * Changed name of SBO:0000394 from "SBO:0000394" to "consumption" * Set definition of SBO:0000394 to "A process that consumes a material or conceptual entity. " * Created link SBO:0000394 OBO_REL:is_a> SBO:0000168 * Assigned namespace "sbo" to SBO:0000394 * Populated new object SBO:0000395 (macro) * Changed name of SBO:0000395 from "SBO:0000395" to "encapsulating process" * Set definition of SBO:0000395 to "An aggregation of interactions and entities into a single process." * Created link SBO:0000395 OBO_REL:is_a> SBO:0000375 * Assigned namespace "sbo" to SBO:0000395 * Populated new object SBO:0000396 (macro) * Changed name of SBO:0000396 from "SBO:0000396" to "uncertain process" * Set definition of SBO:0000396 to "An equivocal or conjectural process, whose existence is assumed but not proven." * Created link SBO:0000396 OBO_REL:is_a> SBO:0000375 * Assigned namespace "sbo" to SBO:0000396 * Populated new object SBO:0000397 (macro) * Changed name of SBO:0000397 from "SBO:0000397" to "omitted process" * Set definition of SBO:0000397 to "One or more processes that are not represented in certain representations or interpretations of a model." * Created link SBO:0000397 OBO_REL:is_a> SBO:0000375 * Assigned namespace "sbo" to SBO:0000397 * Populated new object SBO:0000398 (macro) * Changed name of SBO:0000398 from "SBO:0000398" to "logical relationship" * Set definition of SBO:0000398 to "Relationship between entities (material or conceptual) and logical operators, or between logical operators themselves. " * Created link SBO:0000398 OBO_REL:is_a> SBO:0000374 * Assigned namespace "sbo" to SBO:0000398 * Populated new object SBO:0000399 (macro) * Changed name of SBO:0000399 from "SBO:0000399" to "decarboxylation" * Set definition of SBO:0000399 to "A process in which a carboxyl group (COOH) is removed from a molecule as carbon dioxide." * Created link SBO:0000399 OBO_REL:is_a> SBO:0000211 * Assigned namespace "sbo" to SBO:0000399 * Populated new object SBO:0000400 (macro) * Changed name of SBO:0000400 from "SBO:0000400" to "decarbonylation" * Set definition of SBO:0000400 to "Removal of a carbonyl group (CO) from a molecule, usually as carbon monoxide" * Created link SBO:0000400 OBO_REL:is_a> SBO:0000211 * Assigned namespace "sbo" to SBO:0000400 * Populated new object SBO:0000401 (macro) * Changed name of SBO:0000401 from "SBO:0000401" to "deamination" * Set definition of SBO:0000401 to "Removal of an amine group from a molecule, often uder the addition of water" * Created link SBO:0000401 OBO_REL:is_a> SBO:0000211 * Assigned namespace "sbo" to SBO:0000401 * Populated new object SBO:0000402 (macro) * Changed name of SBO:0000402 from "SBO:0000402" to "transfer of a chemical group" * Set definition of SBO:0000402 to "Covalent reaction that results in the transfer of a chemical group from one molecule to another." * Created link SBO:0000402 OBO_REL:is_a> SBO:0000182 * Assigned namespace "sbo" to SBO:0000402 * Populated new object SBO:0000403 (macro) * Changed name of SBO:0000403 from "SBO:0000403" to "transamination" * Set definition of SBO:0000403 to "The transfer of an amino group between two molecules. Commonly in biology this is restricted to reactions between an amino acid and an alphaketo carbonic acid, whereby the reacting amino acid is converted into an alphaketo acid, and the alphaketo acid reactant into an amino acid." * Created link SBO:0000403 OBO_REL:is_a> SBO:0000402 * Assigned namespace "sbo" to SBO:0000403 * Populated new object SBO:0000404 (macro) * Changed name of SBO:0000404 from "SBO:0000404" to "unit of genetic information" * Created link SBO:0000404 OBO_REL:is_a> SBO:0000241 * Assigned namespace "sbo" to SBO:0000404 * Populated new object SBO:0000405 (macro) * Changed name of SBO:0000405 from "SBO:0000405" to "perturbing agent" * Set definition of SBO:0000405 to "A material entity that is responsible for a perturbing effect" * Created link SBO:0000405 OBO_REL:is_a> SBO:0000240 * Assigned namespace "sbo" to SBO:0000405 * Populated new object SBO:0000406 (macro) * Changed name of SBO:0000406 from "SBO:0000406" to "observable" * Set definition of SBO:0000406 to "An entity that can be measured quantitatively" * Created link SBO:0000406 OBO_REL:is_a> SBO:0000240 * Assigned namespace "sbo" to SBO:0000406 * Changed name of SBO:0000000 from "Systems Biology Ontology" to "sbo term" * Deleted SBO:0000002 part_of> SBO:0000000 * Created link SBO:0000002 OBO_REL:is_a> SBO:0000000 * Changed name of SBO:0000003 from "functional participant" to "participant role" * Deleted SBO:0000003 OBO_REL:is_a> SBO:0000235 * Created link SBO:0000003 OBO_REL:is_a> SBO:0000000 * Deleted SBO:0000004 part_of> SBO:0000000 * Created link SBO:0000004 OBO_REL:is_a> SBO:0000000 * Changed name of SBO:0000012 from "mass action kinetics" to "mass action rate law" * Changed definition of SBO:0000012 from "The Law of Mass Action, first expressed by Waage and Guldberg in 1864 (Waage, P., Guldberg, C. M. Forhandlinger: VidenskabsSelskabet i Christiana 1864, 35) states that the speed of a chemical reaction is proportional to the quantity of the reacting substances. More formally, the change of a product quantity is proportional to the product of reactant activities. In the case of a reaction occurring in a gas phase, the activities are equal to the partial pressures. In the case of a wellstirred aqueous medium, the activities are equal to the concentrations. In the case of discrete kinetic description, the quantity are expressed in number of molecules and the relevant volume are implicitely embedded in the kinetic constant. " to "The Law of Mass Action, first expressed by Waage and Guldberg in 1864 (Waage, P., Guldberg, C. M. Forhandlinger: VidenskabsSelskabet i Christiana 1864, 35) states that the speed of a chemical reaction is proportional to the quantity of the reacting substances. More formally, the change of a product quantity is proportional to the product of reactant activities. In the case of a reaction occurring in a gas phase, the activities are equal to the partial pressures. In the case of a wellstirred aqueous medium, the activities are equal to the concentrations. In the case of discrete kinetic description, the quantity are expressed in number of molecules and the relevant volume are implicitely embedded in the kinetic constant." * Changed name of SBO:0000028 from "kinetics of irreversible nonmodulated unireactant enzymes" to "enzymatic rate law for irreversible nonmodulated noninteracting unireactant enzymes" * Changed name of SBO:0000029 from "HenriMichaelisMenten equation" to "HenriMichaelisMenten rate law" * Changed definition of SBO:0000029 from "First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois G??n??rales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333369. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000373">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" to "First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois G??n??rales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333369.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000373">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000030 from "Van SlykeCullen equation" to "Van SlykeCullen rate law" * Changed definition of SBO:0000030 from "Ratelaw presented in "Donald D. Van Slyke and Glenn E. Cullen. The mode of action of urease and of enzymes in general. J. Biol. Chem., Oct 1914, 19: 141180". It assumes that the enzymatic reaction occurs as two irreversible steps.E+S > ES > E+P. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since K now represents the ration between the production rate and the association rate of the enzyme and the substrate. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000372">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" to "Ratelaw presented in "Donald D. Van Slyke and Glenn E. Cullen. The mode of action of urease and of enzymes in general. J. Biol. Chem., Oct 1914, 19: 141180". It assumes that the enzymatic reaction occurs as two irreversible steps.E+S > ES > E+P. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since K now represents the ration between the production rate and the association rate of the enzyme and the substrate.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000372">Ks</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Ks</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000031 from "BriggsHaldane equation" to "BriggsHaldane rate law" * Changed definition of SBO:0000031 from "Ratelaw presented in "G.E. Briggs and J.B.S. Haldane (1925) A note on the kinetics of enzyme action, Biochem. J., 19: 338339". It is a general rate equation that does not require the restriction of equilibrium of HenriMichaelisMenten or irreversible reactions of Van Slyke, but instead make the hypothesis that the complex enzymesubstrate is in quasisteadystate. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since Km now represents a pseudoequilibrium constant, and is equal to the ratio between the rate of consumption of the complex (sum of dissociation of substrate and generation of product) and the association rate of the enzyme and the substrate. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000371">Km</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Km</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" to "Ratelaw presented in "G.E. Briggs and J.B.S. Haldane (1925) A note on the kinetics of enzyme action, Biochem. J., 19: 338339". It is a general rate equation that does not require the restriction of equilibrium of HenriMichaelisMenten or irreversible reactions of Van Slyke, but instead make the hypothesis that the complex enzymesubstrate is in quasisteadystate. Although of the same form than the HenriMichaelisMenten equation, it is semantically different since Km now represents a pseudoequilibrium constant, and is equal to the ratio between the rate of consumption of the complex (sum of dissociation of substrate and generation of product) and the association rate of the enzyme and the substrate.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000371">Km</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>Km</ci> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000041 from "irreversible mass action kinetics" to "mass action rate law for irreversible reactions" * Changed name of SBO:0000042 from "reversible mass action kinetics" to "mass action rate law for reversible reactions" * Changed name of SBO:0000043 from "zeroth order irreversible mass action kinetics" to "mass action rate law for zeroth order irreversible reactions" * Changed name of SBO:0000044 from "first order irreversible mass action kinetics" to "mass action rate law for first order irreversible reactions" * Changed name of SBO:0000045 from "second order irreversible mass action kinetics" to "mass action rate law for second order irreversible reactions" * Changed name of SBO:0000047 from "zeroth order irreversible mass action kinetics, continuous scheme" to "mass action rate law for zeroth order irreversible reactions, continuous scheme" * Changed name of SBO:0000049 from "first order irreversible mass action kinetics, continuous scheme" to "mass action rate law for first order irreversible reactions, continuous scheme" * Changed name of SBO:0000050 from "second order irreversible mass action kinetics, one reactant" to "mass action rate law for second order irreversible reactions, one reactant" * Changed name of SBO:0000052 from "second order irreversible mass action kinetics, one reactant, continuous scheme" to "mass action rate law for second order irreversible reactions, one reactant, continuous scheme" * Changed name of SBO:0000053 from "second order irreversible mass action kinetics, two reactants" to "mass action rate law for second order irreversible reactions, two reactants" * Changed name of SBO:0000054 from "second order irreversible mass action kinetics, two reactants, continuous scheme" to "mass action rate law for second order irreversible reactions, two reactants, continuous scheme" * Changed name of SBO:0000055 from "third order irreversible mass action kinetics" to "mass action rate law for third order irreversible reactions" * Changed name of SBO:0000056 from "third order irreversible mass action kinetics, one reactant" to "mass action rate law for third order irreversible reactions, one reactant" * Changed definition of SBO:0000056 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the cube of one reactant quantity. " to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the cube of one reactant quantity." * Changed name of SBO:0000057 from "third order irreversible mass action kinetics, one reactant, continuous scheme" to "mass action rate law for third order irreversible reactions, one reactant, continuous scheme" * Changed definition of SBO:0000057 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products, and the change of a product quantity is proportional to the cube of one reactant quantity. It is to be used in a reaction modelled using a continuous framework. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000037">k</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <apply> <times/> <ci>k</ci> <ci>R</ci> <ci>R</ci> <ci>R</ci> </apply> </lambda> </semantics> </math>" to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products, and the change of a product quantity is proportional to the cube of one reactant quantity. It is to be used in a reaction modelled using a continuous framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000037">k</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <apply> <times/> <ci>k</ci> <ci>R</ci> <ci>R</ci> <ci>R</ci> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000058 from "third order irreversible mass action kinetics, two reactants" to "mass action rate law for third order irreversible reactions, two reactants" * Changed definition of SBO:0000058 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant. " to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant." * Changed name of SBO:0000059 from "third order irreversible mass action kinetics, two reactants, continuous scheme" to "mass action rate law for third order irreversible reactions, two reactants, continuous scheme" * Changed definition of SBO:0000059 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant. It is to be used in a reaction modelled using a continuous framework. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000037">k</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <apply> <times/> <ci>k</ci> <ci>R1</ci> <ci>R1</ci> <ci>R2</ci> </apply> </lambda> </semantics> </math>" to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant. It is to be used in a reaction modelled using a continuous framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000037">k</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <apply> <times/> <ci>k</ci> <ci>R1</ci> <ci>R1</ci> <ci>R2</ci> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000060 from "third order irreversible mass action kinetics, three reactants" to "mass action rate law for third order irreversible reactions, three reactants" * Changed name of SBO:0000061 from "third order irreversible mass action kinetics, three reactants, continuous scheme" to "mass action rate law for third order irreversible reactions, three reactants, continuous scheme" * Changed definition of SBO:0000061 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products, and the change of a product quantity is proportional to the product of three reactant quantities. It is to be used in a reaction modelled using a continuous framework. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000036">k</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R3</ci></bvar>; <apply> <times/> <ci>k</ci> <ci>R1</ci> <ci>R2</ci> <ci>R3</ci> </apply> </lambda> </semantics> </math>" to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products, and the change of a product quantity is proportional to the product of three reactant quantities. It is to be used in a reaction modelled using a continuous framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000036">k</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R3</ci></bvar>; <apply> <times/> <ci>k</ci> <ci>R1</ci> <ci>R2</ci> <ci>R3</ci> </apply> </lambda> </semantics> </math>" * Deleted SBO:0000064 part_of> SBO:0000000 * Created link SBO:0000064 OBO_REL:is_a> SBO:0000000 * Changed name of SBO:0000069 from "zeroth order forward reversible mass action kinetics" to "mass action rate law for zeroth order reversible reactions" * Changed name of SBO:0000070 from "zeroth order forward, first order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for zeroth order forward, first order reverse, reversible reactions, continuous scheme" * Changed name of SBO:0000071 from "zeroth order forward, second order reverse, reversible mass action kinetics" to "mass action rate law for zeroth order forward, second order reverse, reversible reactions, continuous scheme" * Changed name of SBO:0000072 from "zeroth order forward, second order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for zeroth order forward, second order reverse, reversible reactions, one product, continuous scheme" * Changed name of SBO:0000073 from "zeroth order forward, second order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for zeroth order forward, second order reverse, reversible reactions, two products, continuous scheme" * Changed name of SBO:0000074 from "zeroth order forward, third order reverse, reversible mass action kinetics" to "mass action rate law for zeroth order forward, third order reverse, reversible reactions, continuous scheme" * Changed name of SBO:0000075 from "zeroth order forward, third order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for zeroth order forward, third order reverse, reversible reactions, one product, continuous scheme" * Changed name of SBO:0000076 from "zeroth order forward, third order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for zeroth order forward, third order reverse, reversible reactions, two products, continuous scheme" * Changed name of SBO:0000077 from "zeroth order forward, third order reverse with three products, reversible mass action kinetics, continuous scheme" to "mass action rate law for zeroth order forward, third order reverse, reversible reactions, three products, continuous scheme" * Changed name of SBO:0000078 from "first order forward reversible mass action kinetics" to "mass action rate law for first order reversible reactions" * Changed name of SBO:0000079 from "first order forward, zeroth order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for first order forward, zeroth order reverse, reversible reactions, continuous scheme" * Changed name of SBO:0000080 from "first order forward, first order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for first order forward, first order reverse, reversible reactions, continuous scheme" * Changed name of SBO:0000081 from "first order forward, second order reverse, reversible mass action kinetics" to "mass action rate law for first order forward, second order reverse, reversible reactions" * Changed name of SBO:0000082 from "first order forward, second order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for first order forward, second order reverse, reversible reactions, one product, continuous scheme" * Changed name of SBO:0000083 from "first order forward, second order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for first order forward, second order reverse, reversible reactions, two products, continuous scheme" * Changed name of SBO:0000084 from "first order forward, third order reverse, reversible mass action kinetics" to "mass action rate law for first order forward, third order reverse, reversible reactions" * Changed name of SBO:0000085 from "first order forward, third order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for first order forward, third order reverse, reversible reactions, one product, continuous scheme" * Changed name of SBO:0000086 from "first order forward, third order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for first order forward, third order reverse, reversible reactions, two products, continuous scheme" * Changed name of SBO:0000087 from "first order forward, third order reverse with three products, reversible mass action kinetics, continuous scheme" to "mass action rate law for first order forward, third order reverse, reversible reactions, three products, continuous scheme" * Changed name of SBO:0000088 from "second order forward reversible mass action kinetics" to "mass action rate law for second order reversible reactions" * Changed name of SBO:0000089 from "second order forward with one reactant reversible mass action kinetics" to "mass action rate law for second order forward, reversible reactions, one reactant" * Changed name of SBO:0000090 from "second order forward with one reactant, zeroth order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, zeroth order reverse, reversible reactions, one reactant, continuous scheme" * Changed name of SBO:0000091 from "second order forward with one reactant, first order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, first order reverse, reversible reactions, one reactant, continuous scheme" * Changed name of SBO:0000092 from "second order forward with one reactant, second order reverse, reversible mass action kinetics" to "mass action rate law for second order forward, second order reverse, reversible reactions, one reactant" * Changed name of SBO:0000093 from "second order forward with one reactant, second order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, second order reverse, reversible reactions, one reactant, one product, continuous scheme" * Changed name of SBO:0000094 from "second order forward with one reactant, second order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, second order reverse, reversible reactions, two products, continuous scheme" * Changed name of SBO:0000095 from "second order forward with one reactant, third order reverse, reversible mass action kinetics" to "mass action rate law for second order forward, third order reverse, reversible reactions, one reactant" * Changed name of SBO:0000096 from "second order forward with one reactant, third order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, third order reverse, reversible reactions, one reactant, one product, continuous scheme" * Changed name of SBO:0000097 from "second order forward with one reactant, third order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, third order reverse, reversible reactions, one reactant, two products, continuous scheme" * Changed name of SBO:0000098 from "second order forward with one reactant, third order reverse with three products, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, third order reverse, reversible reactions, one reactant, three products, continuous scheme" * Changed name of SBO:0000099 from "second order forward with two reactants reversible mass action kinetics" to "mass action rate law for second order forward, reversible reactions, two reactants" * Changed name of SBO:0000100 from "second order forward with two reactants, zeroth order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, zeroth order reverse, reversible reactions, two reactants, continuous scheme" * Changed name of SBO:0000101 from "second order forward with two reactants, first order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, first order reverse, reversible reactions, two reactants, continuous scheme" * Changed name of SBO:0000102 from "second order forward with two reactants, second order reverse, reversible mass action kinetics" to "mass action rate law for second order forward, second order reverse, reversible reactions, two reactants" * Changed name of SBO:0000103 from "second order forward with two reactants, second order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, second order reverse, reversible reactions, two reactants, one product, continuous scheme" * Changed name of SBO:0000104 from "second order forward with two reactants, second order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, second order reverse, reversible reactions, two reactants, two products, continuous scheme" * Changed name of SBO:0000105 from "second order forward with two reactants, third order reverse, reversible mass action kinetics" to "mass action rate law for second order forward, third order reverse, reversible reactions, two reactants" * Changed name of SBO:0000106 from "second order forward with two reactants, third order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, third order reverse, reversible reactions, two reactants, one product, continuous scheme" * Changed name of SBO:0000107 from "second order forward with two reactants, third order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, third order reverse, reversible reactions, two reactants, two products, continuous scheme" * Changed name of SBO:0000108 from "second order forward with two reactants, third order reverse with three products, reversible mass action kinetics, continuous scheme" to "mass action rate law for second order forward, third order reverse, reversible reactions, two reactants, three products, continuous scheme" * Changed name of SBO:0000109 from "third order forward reversible mass action kinetics" to "mass action rate law for third order reversible reactions" * Changed name of SBO:0000110 from "third order forward with two reactants reversible mass action kinetics" to "mass action rate law for third order forward, reversible reactions, two reactants" * Changed name of SBO:0000111 from "third order forward with two reactants, zeroth order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, zeroth order reverse, reversible reactions, two reactants, continuous scheme" * Changed name of SBO:0000112 from "third order forward with two reactants, first order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, first order reverse, reversible reactions, two reactants, continuous scheme" * Changed name of SBO:0000113 from "third order forward with two reactants, second order reverse, reversible mass action kinetics" to "mass action rate law for third order forward, second order reverse, reversible reactions, two reactants" * Changed name of SBO:0000114 from "third order forward with two reactants, second order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, second order reverse, reversible reactions, two reactants, one product, continuous scheme" * Changed name of SBO:0000115 from "third order forward with two reactants, second order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, second order reverse, reversible reactions, two reactants, two products, continuous scheme" * Changed name of SBO:0000116 from "third order forward with two reactants, third order reverse, reversible mass action kinetics" to "mass action rate law for third order forward, third order reverse, reversible reactions, two reactants" * Changed name of SBO:0000117 from "third order forward with two reactants, third order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, two reactants, one product, continuous scheme" * Changed name of SBO:0000118 from "third order forward with two reactants, third order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, two reactants, two products, continuous scheme" * Changed name of SBO:0000119 from "third order forward with two reactants, third order reverse with three products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, two reactants, three products, continuous scheme" * Changed name of SBO:0000120 from "third order forward with three reactants reversible mass action kinetics" to "mass action rate law for third order forward, reversible reactions, three reactants" * Changed name of SBO:0000121 from "third order forward with three reactants, zeroth order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, zeroth order reverse, reversible reactions, three reactants, continuous scheme" * Changed name of SBO:0000122 from "third order forward with three reactants, first order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, first order reverse, reversible reactions, three reactants, continuous scheme" * Changed name of SBO:0000123 from "third order forward with three reactants, second order reverse, reversible mass action kinetics" to "mass action rate law for third order forward, second order reverse, reversible reactions, three reactants" * Changed name of SBO:0000124 from "third order forward with three reactants, second order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, second order reverse, reversible reactions, three reactants, one product, continuous scheme" * Changed name of SBO:0000125 from "third order forward with three reactants, second order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, second order reverse, reversible reactions, three reactants, two products, continuous scheme" * Changed name of SBO:0000126 from "third order forward with three reactants, third order reverse, reversible mass action kinetics" to "mass action rate law for third order forward, third order reverse, reversible reactions, three reactants" * Changed name of SBO:0000127 from "third order forward with three reactants, third order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, three reactants, one product, continuous scheme" * Changed name of SBO:0000128 from "third order forward with three reactants, third order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, three reactants, two products, continuous scheme" * Changed name of SBO:0000129 from "third order forward with three reactants, third order reverse with three products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, three reactants, three products, continuous scheme" * Changed name of SBO:0000130 from "third order forward with one reactant reversible mass action kinetics" to "mass action rate law for third order forward, reversible reactions, one reactant" * Changed name of SBO:0000131 from "third order forward with one reactant, zeroth order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, zeroth order reverse, reversible reactions, one reactant, continuous scheme" * Changed name of SBO:0000132 from "third order forward with one reactant, first order reverse, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, first order reverse, reversible reactions, one reactant, continuous scheme" * Changed name of SBO:0000133 from "third order forward with one reactant, second order reverse, reversible mass action kinetics" to "mass action rate law for third order forward, second order reverse, reversible reactions, one reactant" * Changed name of SBO:0000134 from "third order forward with one reactant, second order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, second order reverse, reversible reactions, one reactant, one product, continuous scheme" * Changed name of SBO:0000135 from "third order forward with one reactant, second order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, second order reverse, reversible reactions, one reactant, two products, continuous scheme" * Changed name of SBO:0000136 from "third order forward with one reactant, third order reverse, reversible mass action kinetics" to "mass action rate law for third order forward, third order reverse, reversible reactions, one reactant" * Changed name of SBO:0000137 from "third order forward with one reactant, third order reverse with one product, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, one reactant, one product, continuous scheme" * Changed name of SBO:0000138 from "third order forward with one reactant, third order reverse with two products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, one reactant, two products, continuous scheme" * Changed name of SBO:0000139 from "third order forward with one reactant, third order reverse with three products, reversible mass action kinetics, continuous scheme" to "mass action rate law for third order forward, third order reverse, reversible reactions, one reactant, three products, continuous scheme" * Changed name of SBO:0000140 from "zeroth order irreversible mass action kinetics, discrete scheme" to "mass action rate law for zeroth order irreversible reactions, discrete scheme" * Changed name of SBO:0000141 from "first order irreversible mass action kinetics, discrete scheme" to "mass action rate law for first order irreversible reactions, discrete scheme" * Changed name of SBO:0000142 from "second order irreversible mass action kinetics, one reactant, discrete scheme" to "mass action rate law for second order irreversible reactions, one reactant, discrete scheme" * Changed name of SBO:0000143 from "second order irreversible mass action kinetics, two reactants, discrete scheme" to "mass action rate law for second order irreversible reactions, two reactants, discrete scheme" * Changed name of SBO:0000144 from "third order irreversible mass action kinetics, one reactant, discrete scheme" to "mass action rate law for third order irreversible reactions, one reactant, discrete scheme" * Changed definition of SBO:0000144 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the cube of one reactant quantity. It is to be used in a reaction modelled using a discrete framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000063">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000068">c</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <apply> <times/> <ci>c</ci> <apply> <divide/> <apply> <times/> <ci>R</ci> <apply> <minus/> <ci>R</ci> <cn type="integer">1</cn> </apply> <apply> <minus/> <ci>R</ci> <cn type="integer">2</cn> </apply> </apply> <cn type="integer">6</cn> </apply> </apply> </lambda> </semantics> </math>" to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the cube of one reactant quantity. It is to be used in a reaction modelled using a discrete framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000063">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000068">c</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <apply> <times/> <ci>c</ci> <apply> <divide/> <apply> <times/> <ci>R</ci> <apply> <minus/> <ci>R</ci> <cn type="integer">1</cn> </apply> <apply> <minus/> <ci>R</ci> <cn type="integer">2</cn> </apply> </apply> <cn type="integer">6</cn> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000145 from "third order irreversible mass action kinetics, two reactants, discrete scheme" to "mass action rate law for third order irreversible reactions, two reactants, discrete scheme" * Changed definition of SBO:0000145 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant. It is to be used in a reaction modelled using a discrete framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000063">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000068">c</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <apply> <times/> <ci>c</ci> <ci>R1</ci> <apply> <divide/> <apply> <times/> <ci>R2</ci> <apply> <minus/> <ci>R2</ci> <cn type="integer">1</cn> </apply> </apply> <cn type="integer">2</cn> </apply> </apply> </lambda> </semantics> </math> " to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of one reactant and the square of the quantity of the other reactant. It is to be used in a reaction modelled using a discrete framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000063">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000068">c</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <apply> <times/> <ci>c</ci> <ci>R1</ci> <apply> <divide/> <apply> <times/> <ci>R2</ci> <apply> <minus/> <ci>R2</ci> <cn type="integer">1</cn> </apply> </apply> <cn type="integer">2</cn> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000146 from "third order irreversible mass action kinetics, three reactants, discrete scheme" to "mass action rate law for third order irreversible reactions, three reactants, discrete scheme" * Changed definition of SBO:0000146 from "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of three reactants. It is to be used in a reaction modelled using a discrete framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000063">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000068">c</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R3</ci></bvar>; <apply> <times/> <ci>c</ci> <ci>R1</ci> <ci>R2</ci> <ci>R3</ci> </apply> </lambda> </semantics> </math> " to "Reaction scheme where the products are created from the reactants and the change of a product quantity is proportional to the product of reactant activities. The reaction scheme does not include any reverse process that creates the reactants from the products. The change of a product quantity is proportional to the quantity of three reactants. It is to be used in a reaction modelled using a discrete framework.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000063">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000068">c</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R3</ci></bvar>; <apply> <times/> <ci>c</ci> <ci>R1</ci> <ci>R2</ci> <ci>R3</ci> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000150 from "kinetics of irreversible nonmodulated noninteracting reactant enzymes" to "enzymatic rate law for irreversible nonmodulated noninteracting reactant enzymes" * Changed name of SBO:0000151 from "kinetics of irreversible nonmodulated noninteracting bireactant enzymes" to "enzymatic rate law for irreversible nonmodulated noninteracting bireactant enzymes" * Changed name of SBO:0000152 from "kinetics of irreversible nonmodulated noninteracting trireactant enzymes" to "enzymatic rate law for irreversible nonmodulated noninteracting trireactant enzymes" * Changed name of SBO:0000163 from "irreversible mass action kinetics, continuous scheme" to "mass action rate law for irreversible reactions, continuous scheme" * Changed name of SBO:0000166 from "irreversible mass action kinetics, discrete scheme" to "mass action rate law for irreversible reactions, discrete scheme" * Changed name of SBO:0000231 from "event" to "interaction" * Changed definition of SBO:0000231 from "Something that happens at a given place and time, and that involves participating entities." to "Mutual or reciprocal action or influence that happens at a given place and time between participating entities and/or other interactions. " * Deleted SBO:0000231 part_of> SBO:0000000 * Created link SBO:0000231 OBO_REL:is_a> SBO:0000000 * Changed name of SBO:0000167 from "reaction" to "biochemical or transport reaction" * Deleted SBO:0000167 OBO_REL:is_a> SBO:0000231 * Created link SBO:0000167 OBO_REL:is_a> SBO:0000375 * Deleted SBO:0000168 OBO_REL:is_a> SBO:0000231 * Created link SBO:0000168 OBO_REL:is_a> SBO:0000374 * Changed name of SBO:0000185 from "transport" to "transport reaction" * Changed definition of SBO:0000186 from "Limiting maximal velocity of an enzymatic reaction, reached when the substrate is in large excess and all the enzyme is complexed. NB. The symbol Vmax and the names maximum rate and maximum velocity are in widespread use although under normal circumstances there is no finite substrate concentration at which v = V and hence no maximum in the mathematical sense (Eur. J. Biochem. 128:281291).<math xmlns="http://www.w3.org/1998/Math/MathML">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000013">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <apply> <times/> <ci>Et</ci> <ci>kcat</ci> </apply> </lambda> </math>" to "Limiting maximal velocity of an enzymatic reaction, reached when the substrate is in large excess and all the enzyme is complexed.<math xmlns="http://www.w3.org/1998/Math/MathML">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000013">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <apply> <times/> <ci>Et</ci> <ci>kcat</ci> </apply> </lambda> </math>" * Changed definition of SBO:0000190 from "Empirical parameter created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: ivvii). Determined from a "Hill plot", it is sometimes assumed to be the number of binding or catalytic sites in a polymer, but it is incorrect. In some mechanistic model, the Hill coefficient gives a lower limit for the number of sites. " to "Empirical parameter created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: ivvii)." * Deleted SBO:0000190 OBO_REL:is_a> SBO:0000256 * Created link SBO:0000190 OBO_REL:is_a> SBO:0000382 * Changed name of SBO:0000192 from "Hill equation, generalised form" to "Hilltype rate law, generalised form" * Changed definition of SBO:0000192 from "Empirical equation created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: ivvii). NB. The symbol Vmax and the names maximum rate and maximum velocity are in widespread use although under normal circumstances there is no finite substrate concentration at which v = V and hence no maximum in the mathematical sense (Eur. J. Biochem. 128:281291). <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000186">Vmax</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000191">K</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000190">h</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000256">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>Vmax</ci> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> <apply> <plus/> <apply> <power/> <ci>K</ci> <ci>n</ci> </apply> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> </apply> </lambda> </semantics> </math>" to "Empirical equation created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: ivvii).<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000186">Vmax</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000191">K</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000190">h</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000256">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>Vmax</ci> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> <apply> <plus/> <apply> <power/> <ci>K</ci> <ci>n</ci> </apply> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000195 from "Hill equation, microscopic form" to "Hilltype rate law, microscopic form" * Changed definition of SBO:0000195 from "Hill equation rewriten by creating a pseudomicroscopic constant, equal to the Hill constant powered to the opposite of the Hill coefficient. NB. The symbol Vmax and the names maximum rate and maximum velocity are in widespread use although under normal circumstances there is no finite substrate concentration at which v = V and hence no maximum in the mathematical sense (Eur. J. Biochem. 128:281291).<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000186">Vmax</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000194">K</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000190">h</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>Vmax</ci> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> <apply> <plus/> <apply> <power/> <ci>K</ci> <ci>h</ci> </apply> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> </apply> </lambda> </semantics> </math> " to "Hill equation rewritten by creating a pseudomicroscopic constant, equal to the Hill constant powered to the opposite of the Hill coefficient.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000186">Vmax</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000194">K</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000190">h</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>Vmax</ci> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> <apply> <plus/> <apply> <power/> <ci>K</ci> <ci>h</ci> </apply> <apply> <power/> <ci>R</ci> <ci>h</ci> </apply> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000198 from "Hill equation, reduced form" to "Hilltype rate law, reduced form" * Changed definition of SBO:0000198 from "Hill equation rewriten by replacing the concentration of reactant with its reduced form, that is the concentration divide by a pseudomicroscopic constant, equal to the Hill constant powered to the opposite of the Hill coefficient. NB. The symbol Vmax and the names maximum rate and maximum velocity are in widespread use although under normal circumstances there is no finite substrate concentration at which v = V and hence no maximum in the mathematical sense (Eur. J. Biochem. 128:281291).<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000186">Vmax</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R*</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000190">h</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>Vmax</ci> <apply> <power/> <ci>R*</ci> <ci>h</ci> </apply> </apply> <apply> <plus/> <cn>1</cn> <apply> <power/> <ci>R*</ci> <ci>h</ci> </apply> </apply> </apply> </lambda> </semantics> </math> " to "Hill equation rewritten by replacing the concentration of reactant with its reduced form, that is the concentration divide by a pseudomicroscopic constant, equal to the Hill constant powered to the opposite of the Hill coefficient.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000186">Vmax</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R*</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000190">h</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>Vmax</ci> <apply> <power/> <ci>R*</ci> <ci>h</ci> </apply> </apply> <apply> <plus/> <cn>1</cn> <apply> <power/> <ci>R*</ci> <ci>h</ci> </apply> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000199 from "normalised kinetics of unireactant enzymes" to "normalised enzymatic rate law for unireactant enzymes" * Changed name of SBO:0000205 from "biochemical process" to "composite biochemical process" * Changed definition of SBO:0000205 from "Event that involves the participation of chemical or biological entities and is composed of several elementary steps or reactions. " to "Process that involves the participation of chemical or biological entities and is composed of several elementary steps or reactions. " * Deleted SBO:0000205 OBO_REL:is_a> SBO:0000231 * Created link SBO:0000205 OBO_REL:is_a> SBO:0000375 * Deleted SBO:0000235 part_of> SBO:0000000 * org.geneontology.oboedit.history.ObsoleteObjectHistoryItem@... * Changed name of SBO:0000236 from "physical participant" to "entity" * Changed definition of SBO:0000236 from "Physical type (structural or informational) of an event participant, that is its chemical nature, or the type of action it performs." to "A real being, whether functional or material, that may participate in an interaction, a process or relationship of biological significance. " * Deleted SBO:0000236 OBO_REL:is_a> SBO:0000235 * Created link SBO:0000236 OBO_REL:is_a> SBO:0000000 * Changed name of SBO:0000237 from "combination" to "logical combination" * Deleted SBO:0000237 OBO_REL:is_a> SBO:0000231 * Created link SBO:0000237 OBO_REL:is_a> SBO:0000374 * Changed name of SBO:0000241 from "conceptual entity" to "functional entity" * Changed definition of SBO:0000241 from "A participant defined by its properties of the actions it performs." to "A real thing, defined by its properties or the actions it performs, rather than it physicochemical structure." * Deleted SBO:0000243 OBO_REL:is_a> SBO:0000354 * Created link SBO:0000243 OBO_REL:is_a> SBO:0000404 * Changed definition of SBO:0000256 from "Parameter that depends of the biochemical properties of a system." to "Parameter that depends on the biochemical properties of a system." * Changed name of SBO:0000260 from "simple competitive inhibition of irreversible unireactant enzymes by one inhibitor" to "enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by one inhibitor" * Changed name of SBO:0000262 from "simple uncompetitive inhibition of irreversible unireactant enzymes" to "enzymatic rate law for simple uncompetitive inhibition of irreversible unireactant enzymes" * Changed name of SBO:0000265 from "simple mixedtype inhibition of irreversible unireactant enzymes" to "enzymatic rate law for simple mixedtype inhibition of irreversible unireactant enzymes" * Changed definition of SBO:0000265 from "Inhibition of a unireactant enzyme by one inhibitor that can bind to the complex enzymesubstrate and the free enzyme, possibly with different equilibrium constant, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000268">a</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>S</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I</ci> <apply> <times/> <ci>a</ci> <ci>Ki</ci> </apply></apply> </apply> </apply> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I</ci> <ci>Ki</ci> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" to "Inhibition of a unireactant enzyme by one inhibitor that can bind to the complex enzymesubstrate and the free enzyme, possibly with different equilibrium constant, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000385">a</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>S</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I</ci> <apply> <times/> <ci>a</ci> <ci>Ki</ci> </apply></apply> </apply> </apply> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I</ci> <ci>Ki</ci> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000266 from "simple noncompetitive inhibition of unireactant enzymes" to "enzymatic rate law for simple noncompetitive inhibition of unireactant enzymes" * Changed name of SBO:0000267 from "competitive inhibition of irreversible unireactant enzymes by one inhibitor" to "enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by one inhibitor" * Changed definition of SBO:0000267 from "Inhibition of a unireactant enzyme by one inhibitor that can bind one or several times to the free enzyme, and prevent the binding of the substrate. The enzymes do not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000189">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>S</ci> <apply> <times/> <ci>Ks</ci> <apply> <power/> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I</ci> <ci>Ki</ci> </apply> </apply> <ci>n</ci> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" to "Inhibition of a unireactant enzyme by one inhibitor that can bind one or several times to the free enzyme, and prevent the binding of the substrate. The enzymes do not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000189">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <ci>S</ci> <apply> <times/> <ci>Ks</ci> <apply> <power/> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I</ci> <ci>Ki</ci> </apply> </apply> <ci>n</ci> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000268 from "enzyme kinetics" to "enzymatic rate law" * Changed name of SBO:0000269 from "kinetics of unireactant enzymes" to "enzymatic rate law for unireactant enzymes" * Changed name of SBO:0000270 from "competitive inhibition of irreversible unireactant enzymes by exclusive inhibitors" to "enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by exclusive inhibitors" * Changed name of SBO:0000271 from "competitive inhibition of irreversible unireactant enzymes by two exclusive inhibitors" to "enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by two exclusive inhibitors" * Changed name of SBO:0000273 from "competitive inhibition of irreversible unireactant enzymes by nonexclusive noncooperative inhibitors" to "enzymatic rate law for competitive inhibition of irreversible unireactant enzymes by nonexclusive noncooperative inhibitors" * Changed definition of SBO:0000273 from "Inhibition of a unireactant enzyme by inhibitors that bind independently to the free enzyme and preclude the binding of the substrate. The enzymes do not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000189">m</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <product/> <bvar><ci> i </ci></bvar> <lowlimit><cn type="integer"> 1 </cn></lowlimit> <uplimit><ci> n </ci></uplimit> <apply> <power/> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <apply> <selector/> <ci type="vector">I</ci> <ci> i </ci> </apply> <apply> <selector/> <ci type="vector">Ki</ci> <ci> i </ci> </apply> </apply> </apply> <apply> <selector/> <ci type="vector">m</ci> <ci> i </ci> </apply> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " to "Inhibition of a unireactant enzyme by inhibitors that bind independently to the free enzyme and preclude the binding of the substrate. The enzymes do not catalyse the reactions in both directions.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000189">m</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <product/> <bvar><ci> i </ci></bvar> <lowlimit><cn type="integer"> 1 </cn></lowlimit> <uplimit><ci> n </ci></uplimit> <apply> <power/> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <apply> <selector/> <ci type="vector">I</ci> <ci> i </ci> </apply> <apply> <selector/> <ci type="vector">Ki</ci> <ci> i </ci> </apply> </apply> </apply> <apply> <selector/> <ci type="vector">m</ci> <ci> i </ci> </apply> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " * Changed name of SBO:0000274 from "simple competitive inhibition of irreversible unireactant enzymes by two nonexclusive inhibitors" to "enzymatic rate law for simple competitive inhibition of irreversible unireactant enzymes by two nonexclusive, noncooperative inhibitors" * Changed definition of SBO:0000274 from "Inhibition of a unireactant enzyme by two inhibitors that can bind independently once to the free enzyme and preclude the binding of the substrate. The enzymes do not catalyse the reactions in both directions.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki2</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I1</ci> <ci>Ki1</ci> </apply> <apply> <divide/> <ci>I2</ci> <ci>Ki2</ci> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " to "Inhibition of a unireactant enzyme by two inhibitors that can bind independently once to the free enzyme and preclude the binding of the substrate. The enzymes do not catalyse the reactions in both directions.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki2</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I1</ci> <ci>Ki1</ci> </apply> <apply> <divide/> <ci>I2</ci> <ci>Ki2</ci> </apply> <apply> <divide/> <apply> <times/> <ci>I1</ci> <ci>I2</ci> </apply> <apply> <times/> <ci>Ki1</ci> <ci>Ki2</ci> </apply> </apply> </apply> </apply> <ci>S</ci> </apply> </apply> </lambda> </semantics> </math> " * Created link SBO:0000274 OBO_REL:is_a> SBO:0000379 * Changed name of SBO:0000275 from "mixedtype inhibition of irreversible enzymes by mutually exclusive inhibitors" to "enzymatic rate law for mixedtype inhibition of irreversible enzymes by mutually exclusive inhibitors" * Changed definition of SBO:0000275 from "Inhibition of a unireactant enzyme by inhibitors that can bind to the complex enzymesubstrate and the free enzyme, possibly with different equilibrium constants, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000268">a</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <sum/> <bvar><ci> i </ci></bvar> <lowlimit><cn type="integer"> 1 </cn></lowlimit> <uplimit><ci> n </ci></uplimit> <apply> <divide/> <apply> <selector/> <ci type="vector">I</ci> <ci> i </ci> </apply> <apply> <selector/> <ci type="vector">Ki</ci> <ci> i </ci> </apply> </apply> </apply> </apply> </apply> <apply> <times/> <ci>S</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <sum/> <bvar><ci> i </ci></bvar> <lowlimit><cn type="integer"> 1 </cn></lowlimit> <uplimit><ci> n </ci></uplimit> <apply> <divide/> <apply> <selector/> <ci type="vector">I</ci> <ci> i </ci> </apply> <apply> <times/> <apply> <selector/> <ci type="vector">a</ci> <ci> i </ci> </apply> <apply> <selector/> <ci type="vector">Ki</ci> <ci> i </ci> </apply> </apply> </apply> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" to "Inhibition of a unireactant enzyme by inhibitors that can bind to the complex enzymesubstrate and the free enzyme, possibly with different equilibrium constants, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000385">a</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000272">n</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <sum/> <bvar><ci> i </ci></bvar> <lowlimit><cn type="integer"> 1 </cn></lowlimit> <uplimit><ci> n </ci></uplimit> <apply> <divide/> <apply> <selector/> <ci type="vector">I</ci> <ci> i </ci> </apply> <apply> <selector/> <ci type="vector">Ki</ci> <ci> i </ci> </apply> </apply> </apply> </apply> </apply> <apply> <times/> <ci>S</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <sum/> <bvar><ci> i </ci></bvar> <lowlimit><cn type="integer"> 1 </cn></lowlimit> <uplimit><ci> n </ci></uplimit> <apply> <divide/> <apply> <selector/> <ci type="vector">I</ci> <ci> i </ci> </apply> <apply> <times/> <apply> <selector/> <ci type="vector">a</ci> <ci> i </ci> </apply> <apply> <selector/> <ci type="vector">Ki</ci> <ci> i </ci> </apply> </apply> </apply> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000276 from "mixedtype inhibition of irreversible unireactant enzymes by two inhibitors" to "enzymatic rate law for mixedtype inhibition of irreversible unireactant enzymes by two inhibitors" * Changed definition of SBO:0000276 from "Inhibition of unireactant enzymes by two inhibitors that can bind to the complex enzymesubstrate and the free enzyme, possibly with different equilibrium constant, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000268">a</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000268">b</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>S</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I1</ci> <apply> <times/> <ci>a</ci> <ci>Ki1</ci> </apply> </apply> <apply> <divide/> <ci>I2</ci> <apply> <times/> <ci>b</ci> <ci>Ki2</ci> </apply> </apply> </apply> </apply> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I1</ci> <ci>Ki1</ci> </apply> <apply> <divide/> <ci>I2</ci> <ci>Ki2</ci> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" to "Inhibition of unireactant enzymes by two inhibitors that can bind to the complex enzymesubstrate and the free enzyme, possibly with different equilibrium constant, and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000020">I2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki1</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki2</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000385">a</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000385">b</ci></bvar>; <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>S</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I1</ci> <apply> <times/> <ci>a</ci> <ci>Ki1</ci> </apply> </apply> <apply> <divide/> <ci>I2</ci> <apply> <times/> <ci>b</ci> <ci>Ki2</ci> </apply> </apply> </apply> </apply> <apply> <times/> <ci>Ks</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I1</ci> <ci>Ki1</ci> </apply> <apply> <divide/> <ci>I2</ci> <ci>Ki2</ci> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" * Changed name of SBO:0000277 from "mixedtype inhibition of unireactant enzymes by two inhibitors" to "enzymatic rate law for noncompetitive inhibition of irreversible unireactant enzymes by two exclusively binding inhibitors" * Deleted SBO:0000278 OBO_REL:is_a> SBO:0000354 * Created link SBO:0000278 OBO_REL:is_a> SBO:0000404 * Deleted SBO:0000290 OBO_REL:is_a> SBO:0000241 * Created link SBO:0000290 OBO_REL:is_a> SBO:0000240 * Deleted SBO:0000291 OBO_REL:is_a> SBO:0000241 * Created link SBO:0000291 OBO_REL:is_a> SBO:0000240 * Changed name of SBO:0000297 from "protein" to "protein complex" * Changed definition of SBO:0000324 from "Limiting maximal velocity of the forward reaction of a reversible enzyme, reached when the substrate is in large excess and all the enzyme is complexed. NB. The symbol Vmax and the names maximum rate and maximum velocity are in widespread use although under normal circumstances there is no finite substrate concentration at which v = V and hence no maximum in the mathematical sense (Eur. J. Biochem. 128:281291). <math xmlns="http://www.w3.org/1998/Math/MathML">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000300">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000320">kcatp</ci></bvar>; <apply> <times/> <ci>Et</ci> <ci>kcat</ci> </apply> </lambda> </math>" to "Limiting maximal velocity of the forward reaction of a reversible enzyme, reached when the substrate is in large excess and all the enzyme is complexed.<math xmlns="http://www.w3.org/1998/Math/MathML">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000300">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000320">kcatp</ci></bvar>; <apply> <times/> <ci>Et</ci> <ci>kcat</ci> </apply> </lambda> </math>" * Changed definition of SBO:0000325 from "Limiting maximal velocity of the reverse reaction of a reversible enzyme, reached when the product is in large excess and all the enzyme is complexed. NB. The symbol Vmax and the names maximum rate and maximum velocity are in widespread use although under normal circumstances there is no finite substrate concentration at which v = V and hence no maximum in the mathematical sense (Eur. J. Biochem. 128:281291).<math xmlns="http://www.w3.org/1998/Math/MathML">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000300">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000321">kcats</ci></bvar>; <apply> <times/> <ci>Et</ci> <ci>kcat</ci> </apply> </lambda> </math> " to "Limiting maximal velocity of the reverse reaction of a reversible enzyme, reached when the product is in large excess and all the enzyme is complexed.<math xmlns="http://www.w3.org/1998/Math/MathML">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000300">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000321">kcats</ci></bvar>; <apply> <times/> <ci>Et</ci> <ci>kcat</ci> </apply> </lambda> </math>" * Changed name of SBO:0000326 from "kinetics of nonmodulated unireactant enzymes" to "enzymatic rate law for nonmodulated unireactant enzymes" * Changed definition of SBO:0000326 from "Kinetics of enzymes that react only with one substance, their substrate, and are not modulated by other compounds.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000321">kcats</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000320">kcatp</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000011">P</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000322">Kms</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000323">Kmp</ci></bvar>; <apply> <divide/> <apply> <minus/> <apply> <times/> <ci>kcatp</ci> <ci>Et</ci> <apply> <divide/> <ci>S</ci> <ci>Kms</ci> </apply> </apply> <apply> <times/> <ci>kcats</ci> <ci>Et</ci> <apply> <divide/> <ci>P</ci> <ci>Kmp</ci> </apply> </apply> </apply> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>S</ci> <ci>Kms</ci> </apply> <apply> <divide/> <ci>P</ci> <ci>Kmp</ci> </apply> </apply> </apply> </lambda> </semantics> </math> " to "Kinetics of enzymes that react only with one substance, their substrate, and are not modulated by other compounds.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000321">kcats</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000320">kcatp</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000014">Et</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000015">S</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000011">P</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000322">Kms</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000323">Kmp</ci></bvar>; <apply> <divide/> <apply> <minus/> <apply> <times/> <ci>kcatp</ci> <ci>Et</ci> <apply> <divide/> <ci>S</ci> <ci>Kms</ci> </apply> </apply> <apply> <times/> <ci>kcats</ci> <ci>Et</ci> <apply> <divide/> <ci>P</ci> <ci>Kmp</ci> </apply> </apply> </apply> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>S</ci> <ci>Kms</ci> </apply> <apply> <divide/> <ci>P</ci> <ci>Kmp</ci> </apply> </apply> </apply> </lambda> </semantics> </math>" * Deleted SBO:0000329 OBO_REL:is_a> SBO:0000354 * Created link SBO:0000329 OBO_REL:is_a> SBO:0000404 * Changed name of SBO:0000333 from "monoexponential decay" to "monoexponential decay rate law" * Changed definition of SBO:0000333 from "Monotonical decrease of a quantity proportionally to its value.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000332">l</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <apply> <divide/> <ci>R</ci> <ci>l</ci> </apply> </lambda> </semantics> </math>" to "Monotonic decrease of a quantity proportionally to its value.<math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000332">l</ci></bvar>; <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000010">R</ci></bvar>; <apply> <divide/> <ci>R</ci> <ci>l</ci> </apply> </lambda> </semantics> </math>" * Deleted SBO:0000334 OBO_REL:is_a> SBO:0000354 * Created link SBO:0000334 OBO_REL:is_a> SBO:0000404 * Deleted SBO:0000335 OBO_REL:is_a> SBO:0000354 * Created link SBO:0000335 OBO_REL:is_a> SBO:0000404 * Changed name of SBO:0000342 from "molecular interaction" to "molecular or genetic interaction" * Deleted SBO:0000342 OBO_REL:is_a> SBO:0000231 * Created link SBO:0000342 OBO_REL:is_a> SBO:0000375 * Changed name of SBO:0000344 from "physical interaction" to "molecular interaction" * Changed name of SBO:0000354 from "genetic entity" to "informational molecule segment" * Deleted SBO:0000354 OBO_REL:is_a> SBO:0000241 * Created link SBO:0000354 OBO_REL:is_a> SBO:0000240 * Changed name of SBO:0000357 from "perturbation" to "biological effect of a perturbation" * Deleted SBO:0000357 OBO_REL:is_a> SBO:0000231 * Created link SBO:0000357 OBO_REL:is_a> SBO:0000375 * Changed name of SBO:0000358 from "observable" to "process that affects an observable" * Deleted SBO:0000358 OBO_REL:is_a> SBO:0000231 * Created link SBO:0000358 OBO_REL:is_a> SBO:0000375 * Deleted SBO:0000369 OBO_REL:is_a> SBO:0000354 * Created link SBO:0000369 OBO_REL:is_a> SBO:0000404 
From: Chris Mungall <cjm@yu...>  20091108 07:49:27

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) * Changed definition of SBO:0000475 from "Function created to enable the modeling of cyclic input with on and off phases, eg. light and dark phases in circadian rhythm. Tp represents the 'on' or 'photo' period, Tc the cycle period, and Tw the 'twilight' timescale. Effectively, in light and dark cycles, Tp is the period of light and Tc the total cycle time. Small values of Tw result in steplike changes.Theta0 is the light value at the off state, and Theta1 the additional value at the on phase. Phi is the time of the phase shift offset. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar> <ci> time </ci> </bvar> <bvar> <ci> Theta0 </ci> </bvar> <bvar> <ci> Theta1 </ci> </bvar> <bvar> <ci> Phi </ci> </bvar> <bvar> <ci> Tp </ci> </bvar> <bvar> <ci> Tc </ci> </bvar> <bvar> <ci> Tw </ci> </bvar> <apply> <plus/> <ci> Theta0 </ci> <apply> <times/> <cn> 0.5 </cn> <ci> Theta1 </ci> <apply> <plus/> <apply> <minus/> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <tanh/> <apply> <divide/> <apply> <minus/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <apply> <times/> <ci> Tc </ci> <apply> <floor/> <apply> <divide/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <ci> Tc </ci> </apply> </apply> </apply> </apply> <ci> Tw </ci> </apply> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <tanh/> <apply> <divide/> <apply> <minus/> <apply> <minus/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <apply> <times/> <ci> Tc </ci> <apply> <floor/> <apply> <divide/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <ci> Tc </ci> </apply> </apply> </apply> </apply> <ci> Tp </ci> </apply> <ci> Tw </ci> </apply> </apply> </apply> </apply> <cn type="integer"> 1 </cn> <apply> <tanh/> <apply> <divide/> <apply> <minus/> <apply> <minus/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <apply> <times/> <ci> Tc </ci> <apply> <floor/> <apply> <divide/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <ci> Tc </ci> </apply> </apply> </apply> </apply> <ci> Tc </ci> </apply> <ci> Tw </ci> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" to "Function created to enable the modeling of cyclic input with on and off phases, eg. light and dark phases in circadian rhythm. Tp represents the 'on' or 'photo' period, Tc the cycle period, and Tw the 'twilight' timescale. Effectively, in light and dark cycles, Tp is the period of light and Tc the total cycle time. Small values of Tw result in steplike changes.Theta0 is the light value at the off state, and Theta1 the additional value at the on phase. Phi is the time of the phase shift offset. <math xmlns="http://www.w3.org/1998/Math/MathML">; <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">; <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000347">; time </ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000256">; Theta0 </ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000381">; Theta1 </ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000477">; Phi </ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000347">; Tp </ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000476">; Tc </ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000346">; Tw </ci></bvar> <apply> <plus/> <ci> Theta0 </ci> <apply> <times/> <cn> 0.5 </cn> <ci> Theta1 </ci> <apply> <plus/> <apply> <minus/> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <tanh/> <apply> <divide/> <apply> <minus/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <apply> <times/> <ci> Tc </ci> <apply> <floor/> <apply> <divide/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <ci> Tc </ci> </apply> </apply> </apply> </apply> <ci> Tw </ci> </apply> </apply> </apply> <apply> <plus/> <cn type="integer"> 1 </cn> <apply> <tanh/> <apply> <divide/> <apply> <minus/> <apply> <minus/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <apply> <times/> <ci> Tc </ci> <apply> <floor/> <apply> <divide/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <ci> Tc </ci> </apply> </apply> </apply> </apply> <ci> Tp </ci> </apply> <ci> Tw </ci> </apply> </apply> </apply> </apply> <cn type="integer"> 1 </cn> <apply> <tanh/> <apply> <divide/> <apply> <minus/> <apply> <minus/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <apply> <times/> <ci> Tc </ci> <apply> <floor/> <apply> <divide/> <apply> <plus/> <ci> time </ci> <ci> Phi </ci> </apply> <ci> Tc </ci> </apply> </apply> </apply> </apply> <ci> Tc </ci> </apply> <ci> Tw </ci> </apply> </apply> </apply> </apply> </apply> </lambda> </semantics> </math>" 
From: Chris Mungall <cjm@yu...>  20091114 02:00:51

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) * Added synonym "chemical potential" to SBO:0000303 * Added synonym "standard chemical potential" to SBO:0000463 
From: Chris Mungall <cjm@yu...>  20091120 04:41:39

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: Chris Mungall <cjm@yu...>  20091127 08:01:11

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: Chris Mungall <cjm@yu...>  20091201 22:27:44

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110808 23:26:23

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110809 23:26:09

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110810 22:47:23

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110811 23:00:38

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110812 23:42:31

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110813 23:02:46

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110814 20:23:14

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110815 23:11:41

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110816 23:11:11

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110817 23:27:29

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110818 22:55:44

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
From: <cjm@yu...>  20110819 23:34:45

Starting obodiff at /users/cjm/cvs/geneontology/oboedit/launch_scripts using 1024M of memory [INFO] Reading [oboall/systems_biology/systems_biology.obo.CURRENT] (allowDangling = true) (followImports = true) [INFO] Reading [oboall/systems_biology/systems_biology.obo] (allowDangling = true) (followImports = true) 
Sign up for the SourceForge newsletter:
No, thanks