#34 Incorrect definition of HP:0000841 ! Hyperactive renin-angio

closed-later
nobody
None
5
2011-06-19
2011-01-15
Anonymous
No

The following definition is incorrect, because the PATO term PATO:0000760 refers to "increased behavioural activity" (synonym "hyperactive"), which is a different use of the word "hyperactive". Please consider whether "hyperactive" should be deleted as a synonym for "increased behavioural activity" and change the following definition.

[Term]
id: HP:0000841 ! Hyperactive renin-angiotensin system
intersection_of: PATO:0000760 ! hyperactive
intersection_of: inheres_in FMA:74787 ! Renin-angiotensin system

Discussion

  • Chris Mungall

    Chris Mungall - 2011-01-17

    I suggest changing the synonym type from exact to something else, pending a review / rework of the whole behavior part of pato

     
  • Peter N. Robinson

    I still do not think that the logical definition of this term is correct. I have now provided the following text definition and hope it will help:

    def: An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms.
    comment:If the kidneys sense reduced renal blood flow, as can happen with reduced blood pressure, they secrete renin into the blood, where it reacts with angiotensinogen to produce angiotensin I, which is converted to angiotensin II by angiotensin converting enzyme (ACE). Both angiotensin I and II are vasoconstrictors. Angiotensin II additionally leads to the production of aldosterone by the adrenal cortex, which in turn leads to an increase in blood volume.

     
  • Peter N. Robinson

    • status: open --> closed-later
     

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