#273 Young adult onset inconsistent with parent class

[Melissa Haendel]

Adult onset is defined as: Onset of disease manifestations in adulthood, defined here as at the age of 20 years or later.
subClass Young adult onset defined as: Onset of disease at the age of between 15 and 40 years.

The subClass must be within the temporal range of the superclass.

Also, the onset terms in HPO are also inconsistent with the human developmental stage ontology https://code.google.com/p/developmental-stage-ontologies/wiki/HsapDv
We should reconcile usage here.

[Peter N. Robinson]

Hi Melissa,
at first glance, there seem to be lots of overlapping classes in HsapDv. I would also doubt that HsapDv represents community opinion, since there are as many opinions as there are MDs, I think. Currently, the HPO terms reflect the Oxford Clinical Genetics handbook, which is as close to a standard as the field has. But we need to tend to the young adult term, obviously.

[Term]
id: HsapDv:0000084
name: 2-5 year-old child stage
namespace: human_developmental_stage
def: "Child stage that refers to a child who is over 24 months and under 6 years old." [Bgee:curator]
synonym: "preschool child" RELATED []
is_a: HsapDv:0000000 ! human life cycle stage
relationship: part_of HsapDv:0000081 ! child stage
property_value: end_ypb "6.0" xsd:float
property_value: start_ypb "2.0" xsd:float

[Term]
id: HsapDv:0000085
name: 6-12 year-old child stage
namespace: human_developmental_stage
def: "Child stage that refers to a child who is over 6 and under 13 years old." [Bgee:curator]
synonym: "prepubescent" RELATED []
is_a: HsapDv:0000000 ! human life cycle stage
relationship: part_of HsapDv:0000081 ! child stage
property_value: end_ypb "13.0" xsd:float
property_value: start_ypb "6.0" xsd:float

Dr. med. Peter N. Robinson, MSc.
Professor of Medical Genomics
Professor in the Bioinformatics Division of the Department of Mathematics and Computer Science of the Freie Universität Berlin
Institut für Medizinische Genetik und Humangenetik
Charité - Universitätsmedizin Berlin
Augustenburger Platz 1
13353 Berlin
Germany
+4930 450566006
Mobile: 0160 93769872
peter.robinson@charite.de
http://compbio.charite.de
http://www.human-phenotype-ontology.org
Introduction to Bio-Ontologies: http://www.crcpress.com/product/isbn/9781439836651
I have learned from my mistakes, and I am sure I can repeat them exactly
ORCID ID:http://orcid.org/0000-0002-0736-9199
Scopus Author ID 7403719646
Appointment request: http://doodle.com/pnrobinson

---

Von: Melissa Haendel [mellybelly@users.sf.net]
Gesendet: Montag, 3. März 2014 22:50
An: Ticket 273
Betreff: [obo:human-phenotype-requests] #273 Young adult onset inconsistent with parent class

---

[human-phenotype-requests:#273]http://sourceforge.net/p/obo/human-phenotype-requests/273/ Young adult onset inconsistent with parent class

Status: unread
Group: musculoskeletal
Created: Mon Mar 03, 2014 09:50 PM UTC by Melissa Haendel
Last Updated: Mon Mar 03, 2014 09:50 PM UTC
Owner: nobody

Adult onset is defined as: Onset of disease manifestations in adulthood, defined here as at the age of 20 years or later.
subClass Young adult onset defined as: Onset of disease at the age of between 15 and 40 years.

The subClass must be within the temporal range of the superclass.

Also, the onset terms in HPO are also inconsistent with the human developmental stage ontology https://code.google.com/p/developmental-stage-ontologies/wiki/HsapDv
We should reconcile usage here.

---

Sent from sourceforge.net because you indicated interest in https://sourceforge.net/p/obo/human-phenotype-requests/273/

To unsubscribe from further messages, please visit https://sourceforge.net/auth/subscriptions/

[Melissa Haendel]

I think we can adjust the HsapDv to be consistent with the Oxford standard terminology for the postnatal terms. The prenatal terms are finely typed by Jonathan Bard/EHDAA2 and represent standard Carnegie stages - these are likely the same or at least very similar in Oxford?

But yes, no matter what we choose, we'll likely make someone less than happy ;-).

[Peter N. Robinson]

Young adult should have been defined as from 16 years on to 40.
I have adjust the definition of adult to begin with 16 years.
Obviously there is no good definition of this, but I think this age classification is the most reasonable compromise between biology and culture etc.