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#260 Abnormal inflammatory response
We need a grouping term for the many types of inflammation (for example, gastrointestinal inflammation, inflammatory abnormality of the skin).
This could be defined as an abnormal GO:inflammatory response
(though the GO hierarchy is a bit odd too, this class has superclasses 'response to wounding'
'defense response', probably need some more specific subclasses.
Request was for 'Inflammatory mediated disease', which isn't a good HPO term, but speaks to the need for a generalized abnormality of inflammatory response.
Inflammatory mediated disease can be a normal response of the organism. Abnormal inflammatory response can be say the lack of a response or too much response. I would think the original term request was more of the "too much inflammation" variety, but I dont suppose you have some way of asking?
-Peter
Dr. med. Peter N. Robinson, MSc.
Professor of Medical Genomics
Professor in the Bioinformatics Division of the Department of Mathematics and Computer Science of the Freie Universität Berlin
Institut für Medizinische Genetik und Humangenetik
Charité - Universitätsmedizin Berlin
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Von: Melissa Haendel [mellybelly@users.sf.net]
Gesendet: Sonntag, 26. Januar 2014 18:10
An: Ticket 260
Betreff: [obo:human-phenotype-requests] #260 Abnormal inflammatory response
[human-phenotype-requests:#260]http://sourceforge.net/p/obo/human-phenotype-requests/260/ Abnormal inflammatory response
Status: unread
Created: Sun Jan 26, 2014 05:10 PM UTC by Melissa Haendel
Last Updated: Sun Jan 26, 2014 05:10 PM UTC
Owner: nobody
We need a grouping term for the many types of inflammation (for example, gastrointestinal inflammation, inflammatory abnormality of the skin).
This could be defined as an abnormal GO:inflammatory response
(though the GO hierarchy is a bit odd too, this class has superclasses 'response to wounding'
'defense response', probably need some more specific subclasses.
Request was for 'Inflammatory mediated disease', which isn't a good HPO term, but speaks to the need for a generalized abnormality of inflammatory response.
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#260I will ask, but perhaps good idea to have something general like 'abnormally increased inflammatory response' and 'abnormally decreased inflammatory response'?
I added this as (HP:0012647), def : Any anomaly of the
inflammatory response(GO:0006954), a response to injury or infection characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.Note that we probably need an additional child term to group all of the chronic inflammation terms, gastrointestinal inflammation, inflammatory abnormality of the skin). ANy ideas?