#185 NTR: mature dendritic cell
CL has no class "mature dendritic cell"
This class would group all the following:
CL:0000841 ! mature conventional dendritic cell [subclass: "conventional dendritic cell"]
CL:0000993 ! mature CD11c-low plasmacytoid dendritic cell [subclass: "CD11c-low plasmacytoid dendritic cell"]
CL:0000996 ! mature CD11c-negative plasmacytoid dendritic cell [subclass: "CD11c-negative plasmacytoid dendritic cell"]
CL:0001002 ! mature CD8_alpha-negative CD11b-negative dendritic cell [subclass: "CD8_alpha-negative CD11b-negative dendritic cell"]
CL:0001003 ! mature CD8_alpha-negative CD11b-positive dendritic cell [subclass: "CD4-positive CD11b-positive dendritic cell"]
CL:0001005 ! mature CD8_alpha-positive CD11b-negative dendritic cell [subclass: "CD8_alpha-positive CD11b-negative dendritic cell"]
CL:0001010 ! mature dermal dendritic cell [subclass: "dermal dendritic cell"]
CL:0001013 ! mature interstitial dendritic cell [subclass: "interstitial dendritic cell"]
CL:0002528 ! mature CD14-positive dermal dendritic cell [subclass: "CD14-positive dermal dendritic cell"]
CL:0002531 ! mature CD1a-positive dermal dendritic cell [subclass: "CD1a-positive dermal dendritic cell"]
CL:0002534 ! mature CD16-positive myeloid dendritic cell [subclass: "CD16-positive myeloid dendritic cell"]
required to define:
[Term]
id: GO:0097029
name: mature dendritic cell differentiation
namespace: biological_process
def: "The process in which antigen-activated dendritic cells acquire the specialized features of a mature dendritic cell. Mature dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells." [GOC:BHF, PMID:15845453, http://www.rndsystems.com/mini_review_detail_objectname_MR02_DendriticCellMat.aspx\]
comment: Note that immunologists typically use the word 'maturation' to refer to dendritic cells undergoing the process that GO describes as 'cell differentiation'.
is_a: GO:0097028 ! dendritic cell differentiation
See https://code.google.com/p/cell-ontology/issues/detail?id=135.
"mature dendritic cell" as proposed would group disparate classes, 'mature conventional dendritic cell' and the mature plamsacytoid dendritic cell classes that are distinct cell lineages.
The related GO term GO:0097029 was recently renamed to avoid the need for the term "mature dendritic cell" in the CL, as the term referred to mature conventional dendritic cells.
https://sourceforge.net/p/geneontology/ontology-requests/10974/