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Problem with compare VCF

Anonymous
2018-03-22
2018-03-27
  • Anonymous

    Anonymous - 2018-03-22

    Hi there,

    I'm trying to run CompareVCF on my VCFs, but I'm getting a strange error.

    The command I'm using is:

    java -jar /ohta/joanna.rifkin/NGSEPcore_3.1.1/NGSEPcore.jar CompareVCF -g 0 -d 100 dovetailsequencenames.txt mappingpopulation.vcf mappingpopulation.vcf 1>population_sampleComparation.txt

    The error is (repetitions of):

    Mar 22, 2018 11:18:37 AM ngsep.vcf.VCFFileReader loadGenomicVariant
    SEVERE: Can not load genomic variant at chr_Ft1:60331664. Unrecognized sequence name. Changes have been disabled for this collection
    I haven't had any other problems with the sequence names file, or with any other step in the pipeline. Everything is in the correct directory. Any insight into what might be going on?

    Thanks!

    Joanna Rifkin

    --
    Joanna Rifkin PhD

    Department of Ecology and Evolutionary Biology
    The University of Toronto
    25 Willcocks St.
    Toronto, ON M5S 3B2

     
  • Jorge Duitama

    Jorge Duitama - 2018-03-22

    Hi Johanna

    Thanks for reporting this issue. In the last version we modified the CompareVCF command to improve the comparison of indels that may not have the exact same coordinates in different VCFs. However, the downside of this improvement is that the command now requires the complete reference genome instead of the sequence names file. We updated the inline help with this change but i just noticed that we did not update accordingly the README, so I just uploaded a new version of the README with the documentation of this change. Please use then the fasta file of your reference genome instead of the file "dovetailsequencenames.txt" and let us know if it works.

    Best regards

    Jorge

     
  • Anonymous

    Anonymous - 2018-03-26

    Hi Jorge,

    Thanks, that fixed it perfectly!

    Cheers,

    Joanna

     
  • Jorge Duitama

    Jorge Duitama - 2018-03-27

    No problem. Let us know if you need any further help.

    Jorge

     

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