this is a phenotype for strains lacking hydrolases (phenotype from phage meeting 2011 abstract #79). This has to do with cell wall stability, but the term name would have broader implications.
So, to be clear, we want to describe the observation of more lysis? (This is as opposed to the observation of how much hydrolase is there.) Correct? Can you suggest a place in the ontology (parentage)?
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Upon further reflection, "more lysis" is the wrong term to request. The authors note the triple mutant is inviable, and explain this inviability to the loss of the hydrolases. As for a term, simply "not viable" may be a more general term to describe phenotypes since the observation of inviable cells may not be linked to a specific cause. Under a "not viable" phenotype node, the child terms could be "not viable due to a breach in cell wall integrity" or "not viable due to lysis" would be better. The term "not viable" would be under "growth phenotype" parent term. There is an "absence of growth" term that would be the parent. Good call on this one.
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So, to be clear, we want to describe the observation of more lysis? (This is as opposed to the observation of how much hydrolase is there.) Correct? Can you suggest a place in the ontology (parentage)?
Upon further reflection, "more lysis" is the wrong term to request. The authors note the triple mutant is inviable, and explain this inviability to the loss of the hydrolases. As for a term, simply "not viable" may be a more general term to describe phenotypes since the observation of inviable cells may not be linked to a specific cause. Under a "not viable" phenotype node, the child terms could be "not viable due to a breach in cell wall integrity" or "not viable due to lysis" would be better. The term "not viable" would be under "growth phenotype" parent term. There is an "absence of growth" term that would be the parent. Good call on this one.
This issue has been reviewed and it needs to be discussed if "not viable/viable" are phenotypes we wish to annotate.